Lupus
Annals of Internal Medicine reports that thiopurine toxcicity risk is associated with the "CC" genotype and that azathioprine discontinuation was associated with hematopoietic toxicity and lower thiopurine doses.

Dr. John Cush RheumNow
3 years 2 months ago
Study of 1778 #SLE pts, of whom 121 had refractory thrombocytopenia (TP)(Plt <50K, unresp. to pred), Risk factors included pregnancy, Autoimmune hemolytic anemia, decreased C3, severity of TP and elevated ACL-IgG. https://t.co/ZNqQfUoYUq https://t.co/eQNcKcc9Uz


Dr. John Cush RheumNow
3 years 3 months ago
#EULAR2022 has concluded but you can find all our coverage here https://t.co/s62OVJPQ86 https://t.co/QAvPQYCABj


Dr. John Cush RheumNow
3 years 3 months ago
Watch: Dr. Lucy Carter on RNA-Seq analysis to determine who's at risk for SLE
Dr. Yusof interviews Dr. Lucy Carter ( @LucyCarter6), winner of the #EULAR2022 Best Abstract Award for her work on ANA positivity in those at-risk for progression to #SLE.
https://t.co/BdPnZRgwX4 https://t.co/g8xWWFthVC

A retrospective cohort study has shown that outcomes in pregnant systemic lupus erythematosus (SLE) patients has significantly improved in the last decade, but there still is a high risk of adverse pregnancy outcomes (APO).
A retrospective Danish SLE cohort was used to identify pregnancies in SLE patients from a single center between January 2010 and October 2020.

Dr. John Cush RheumNow
3 years 3 months ago
Cluster study of 383 aPL+ pts showed 4 clusters:
Cluster 1 (138): w/ SLE & non-criteria Sxs
Cluster 2 (112): pts w/ CV risks
Cluster 3 (83): females w/ OB morbidity (BEST outcome)
Cluster 4 (50): lupus anticoagulant (+) (high freq of arterial thrombosis) https://t.co/HGRTceplsn https://t.co/ZDdwhCmj5r

In SLE, two targets that are increasingly used are the DORIS 2021 Remission and the Lupus Low Disease Activity (LLDAS). T2T is more likely to be successful if the treating clinicians and the patients set the treatment goals together. What do our patients think about T2T and do they have any say/concern?

Dr. John Cush RheumNow
3 years 3 months ago
Watch: EULAR 2022 - Day 1 Faculty Recap Pane
Drs. Jack Cush, Eric Dein and Kathryn Dao discuss highlights from day 1 at #EULAR2022 - Guidelines, Lupus, and more.
https://t.co/WSOCQ8K38p https://t.co/0u28QHtxoJ


Dr. John Cush RheumNow
3 years 3 months ago
Watch this 4 minute video on Belimumab use in pregnancy featuring Dr. Kathryn Dao ( @KDAO2011 )
https://t.co/8uRUIVURHF https://t.co/lbYwHFFJit


Md Yuzaiful Md Yusof Yuz6Yusof
3 years 3 months ago
#LB0004 #EULAR2022 Positive Phase 2 results in #lupus! Deucravacitinib, a TYK2-inhibitor reported significantly more SRI-4 response rates in DEUC vs PBO. PBO: 34.4%; DEUC 3 mg BID:58.2%, DEUC 6 mg BID:49.5%, DEUC 12 mg QD:44.9%. No major safety. Will proceed to Phase 3 @RheumNow https://t.co/cZLv6bbHer


Dr. John Cush RheumNow
3 years 3 months ago
Watch: Let’s Talk about Sex and Autoimmune Disease
Dr. Eric Dein discusses abstract OP0139 presented at #EULAR2022.
https://t.co/fNcIbykFqL https://t.co/6UaH5DIc51


TheDaoIndex KDAO2011
3 years 3 months ago
My new blog on “Emerging Therapeutics for #Lupus” #EULAR22 @RheumNow. Tagging @RichardPAConway because he doesn’t sleep. https://t.co/6a8Y00Aw4W