Improved Pregnancy Outcomes in SLE (2010–2020) Save
A retrospective cohort study has shown that outcomes in pregnant systemic lupus erythematosus (SLE) patients has significantly improved in the last decade, but there still is a high risk of adverse pregnancy outcomes (APO).
A retrospective Danish SLE cohort was used to identify pregnancies in SLE patients from a single center between January 2010 and October 2020.
This included 66 pregnancies in 41 women. APO's occurred in 65% of pregnancies; there were 47 live births, and 15 miscarriages. Outcomes were compared to a 1990–2010 SLE cohort.
|2010 - 2020||1990 - 2010||p Value|
|Emergent Cesarean Sections||6.1%||15.5%||0.07|
|Mean Birth Weight (g)||3045||2780|
Compared to 1990-2010, the more recent decade had fewer preterm deliveries and emergent caesarean sections; higher average birth weights, and more pregnancies and live births per year. Gestational hypertension was significantly reduced from 23.8% to 13.6% (p = .05). Significantly more patients were treated with prednisolone, hydroxychloroquine and acetylsalicylic acid in 2010–2020.
Although there were fewer APOs in the 2010–2020 cohort, SLE pregnancy still carries a high risk of APO.