Improved Pregnancy Outcomes in SLE (2010–2020) Save
A retrospective cohort study has shown that outcomes in pregnant systemic lupus erythematosus (SLE) patients has significantly improved in the last decade, but there still is a high risk of adverse pregnancy outcomes (APO).
A retrospective Danish SLE cohort was used to identify pregnancies in SLE patients from a single center between January 2010 and October 2020.
This included 66 pregnancies in 41 women. APO's occurred in 65% of pregnancies; there were 47 live births, and 15 miscarriages. Outcomes were compared to a 1990–2010 SLE cohort.
| 2010 - 2020 | 1990 - 2010 | p Value | |
|---|---|---|---|
| Pre-term Births | 7.58% | 17.9% | 0.07 |
| Emergent Cesarean Sections | 6.1% | 15.5% | 0.07 |
| Mean Birth Weight (g) | 3045 | 2780 | |
| Gestational HTN | 13.6% | 23.8% | 0.05 |
| Prednisolone use | 66.7% | 35.7% | 0.0002 |
| Hydroxychloroquine use | 73.4% | 39.3% | 0.0001 |
Compared to 1990-2010, the more recent decade had fewer preterm deliveries and emergent caesarean sections; higher average birth weights, and more pregnancies and live births per year. Gestational hypertension was significantly reduced from 23.8% to 13.6% (p = .05). Significantly more patients were treated with prednisolone, hydroxychloroquine and acetylsalicylic acid in 2010–2020.
Although there were fewer APOs in the 2010–2020 cohort, SLE pregnancy still carries a high risk of APO.
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