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      RT @KDAO2011: Interestingly, anti-IFN Ab can be present in #SLE pts and impact the IFN signature.

      There is a bimodal t

      TheDaoIndex KDAO2011

      2 years 5 months ago
      Interestingly, anti-IFN Ab can be present in #SLE pts and impact the IFN signature. There is a bimodal type I IFN signature in #SLE. IFN and Blys signatures overlap (?distinct populations/interactions between the two?) - Prof T Dorner #EULAR2022 @rheumnow https://t.co/phLXv2KVxR
      RT @AurelieRheumo: All the domains of sexual sphere are deteriorated in RA and PsA.
      This aspect is often overlooked and

      Aurelie Najm AurelieRheumo

      2 years 5 months ago
      All the domains of sexual sphere are deteriorated in RA and PsA. This aspect is often overlooked and can have a significant impact on pts QoL. It may be time to assess this aspect more specifically using CSFQ-14 and propose dedicated interventions. #OP0139 @RheumNow #EULAR2022 https://t.co/l0zyBIZ1LI
      RT @RichardPAConway: Dr Puja Khanna. Transdermal sodium bicarbonate for gout flare. WHAT!? It works as well! Double-blin

      Richard Conway RichardPAConway

      2 years 5 months ago
      Dr Puja Khanna. Transdermal sodium bicarbonate for gout flare. WHAT!? It works as well! Double-blind RCT. All got colchicine also. Response rate 95% vs 79%. Resolution in 24 vs 72 hrs. Rescue meds 6% vs 20%. No adverse events! @RheumNow #EULAR2022 OP0170 https://t.co/INd4tMFVlV https://t.co/EyVjFLF72z
      RT @ericdeinmd: #EULAR2022 ASAS/EULAR AxSpA Recs
      ⭐️Last: 2016
      ▶️All: education, exercise, 🚭
      ▶️❌csDMARD

      Eric Dein ericdeinmd

      2 years 5 months ago
      #EULAR2022 ASAS/EULAR AxSpA Recs ⭐️Last: 2016 ▶️All: education, exercise, 🚭 ▶️❌csDMARD for axial disease ▶️TNF/IL17 (or JAK) with high disease: ASDAS>/=2.1 ▶️Monoclonal TNF for uveitis/IBD, high PsO: IL-17 ▶️Sustained remission: tapering of bDMARD "can be considered" @RheumNow https://t.co/3yYU0Vb37r
      RT @KDAO2011: Proof that MTX doesn't affect sperm! Sperm morphology, motility, concentration, semen volume, testosterone

      TheDaoIndex KDAO2011

      2 years 5 months ago
      Proof that MTX doesn't affect sperm! Sperm morphology, motility, concentration, semen volume, testosterone/LH/FSH similar b/f and after exposure; DNA fragmentat'n was⬆️in pre-MTX exposure (possible reason high dz activity contributes to infertility) #EULAR2022 @rheumnow OP0131 https://t.co/JWLEggRhAY
      RT @RichardPAConway: Hamroun @annamolto et al. Factors assoc with increased time to conception in SpA. 56 pregnancies. M

      Richard Conway RichardPAConway

      2 years 5 months ago
      Hamroun @annamolto et al. Factors assoc with increased time to conception in SpA. 56 pregnancies. Multivariate model, age (HR 1.22 (1.08-1.40)) and preconception NSAID use (HR 3.01 (2.15-3.85)) assoc increase time to conception. @RheumNow #EULAR2022 OP0153 https://t.co/y2EAyAdRmk https://t.co/28aLimRInE
      RT @KDAO2011: OP0129 Eudravigilance eval pregnancies exposed to non-TNF biologics compared certolizumab. Possible signal

      TheDaoIndex KDAO2011

      2 years 5 months ago
      OP0129 Eudravigilance eval pregnancies exposed to non-TNF biologics compared certolizumab. Possible signal w/#vendolizumab: 3 cases of corpus callosum agenesis (2 Crohn’s, 1 UC, 2 assc w/ other CNS malformations). Belim did not show consistent pattern #EULAR2022 @rheumnow https://t.co/BNKaxu6G0c
      RT @RichardPAConway: Perez-Garcia et al. MTX effect on semen parameters. I still frequently get queries about this. 48 p

      Richard Conway RichardPAConway

      2 years 5 months ago
      Perez-Garcia et al. MTX effect on semen parameters. I still frequently get queries about this. 48 participants here. No significant effect! @RheumNow #EULAR2022 OP0131 https://t.co/33NG6isehm https://t.co/g7Xn33i96u
      RT @Yuz6Yusof: #OP0142 #EULAR2022 Morand compared LLDAS in Early (<1yr) and Established #lupus. Although Early were

      Md Yuzaiful Md Yusof Yuz6Yusof

      2 years 5 months ago
      #OP0142 #EULAR2022 Morand compared LLDAS in Early (<1yr) and Established #lupus. Although Early were younger & had higher disease activity, time-to-LLDAS was shorter. LLDAS was protective of flare in both. Should target for LLDAS early in diagnosis to improve outcomes @RheumNow https://t.co/7i9c69YkR3
      RT @KDAO2011: In people without SLE who have severe COVID19 infection, autoAb against IFN-1 assc w/increased mortality P

      TheDaoIndex KDAO2011

      2 years 5 months ago
      In people without SLE who have severe COVID19 infection, autoAb against IFN-1 assc w/increased mortality Prof T Dorner #EULAR2022 @rheumnow https://t.co/nt2gACUtkL
      RT @RichardPAConway: BIOBADASER Registry data on comparative drug-dependent cancer risk in patients with prior cancer. 3

      Richard Conway RichardPAConway

      2 years 5 months ago
      BIOBADASER Registry data on comparative drug-dependent cancer risk in patients with prior cancer. 352 patients. 32 incident cancers (14 NMSC). No difference between agents, but wide CIs @RheumNow #EULAR2022 OP0138 https://t.co/NEZSL2AQhC https://t.co/EG0NflXXW6
      RT @RichardPAConway: Unizony et al. Case series of tocilizumab + 8 weeks steroid in GCA. 30 patients, 50% new 50% relaps

      Richard Conway RichardPAConway

      2 years 5 months ago
      Unizony et al. Case series of tocilizumab + 8 weeks steroid in GCA. 30 patients, 50% new 50% relapsing. 77% in sustained remission at week 52! No vision loss. Exciting, needs an RCT @RheumNow #EULAR2022 OP0185 https://t.co/ohBYIWYxBC https://t.co/fsn4x17Hwv
      RT @KDAO2011: New #SLE drug to pay attention to!
      iberdomide target Ikaros and Aiolos, reduce B cell, reduce autoAb and

      TheDaoIndex KDAO2011

      2 years 5 months ago
      New #SLE drug to pay attention to! iberdomide target Ikaros and Aiolos, reduce B cell, reduce autoAb and reduce IFN sig while enhancing regulatory T cells- Prof T Dorner #EULAR2022 @rheumnow https://t.co/q39pxK3gFJ
      RT @AurelieRheumo: Spanish safety registry BIOBADASER 3.0:
      *9000+ pts with IMID treated w/ bio or tsDMARDS
      *352 pts w/ p

      Aurelie Najm AurelieRheumo

      2 years 5 months ago
      Spanish safety registry BIOBADASER 3.0: *9000+ pts with IMID treated w/ bio or tsDMARDS *352 pts w/ prior malignancy *32 incident malignancies -> 27 events/1000PY NO diff between ttmts in incidence or mortality but low number pts in non TNFi groups @RheumNow #EULAR2022 OP0138 https://t.co/8IyC6NdGCF