TheDaoIndex KDAO2011
2 years 5 months ago
Interestingly, anti-IFN Ab can be present in #SLE pts and impact the IFN signature.
There is a bimodal type I IFN signature in #SLE.
IFN and Blys signatures overlap (?distinct populations/interactions between the two?) - Prof T Dorner #EULAR2022 @rheumnow https://t.co/phLXv2KVxR
Aurelie Najm AurelieRheumo
2 years 5 months ago
All the domains of sexual sphere are deteriorated in RA and PsA.
This aspect is often overlooked and can have a significant impact on pts QoL. It may be time to assess this aspect more specifically using CSFQ-14 and propose dedicated interventions. #OP0139 @RheumNow #EULAR2022 https://t.co/l0zyBIZ1LI
Richard Conway RichardPAConway
2 years 5 months ago
Dr Puja Khanna. Transdermal sodium bicarbonate for gout flare. WHAT!? It works as well! Double-blind RCT. All got colchicine also. Response rate 95% vs 79%. Resolution in 24 vs 72 hrs. Rescue meds 6% vs 20%. No adverse events! @RheumNow #EULAR2022 OP0170 https://t.co/INd4tMFVlV https://t.co/EyVjFLF72z
Eric Dein ericdeinmd
2 years 5 months ago
#EULAR2022 ASAS/EULAR AxSpA Recs
⭐️Last: 2016
▶️All: education, exercise, 🚭
▶️❌csDMARD for axial disease
▶️TNF/IL17 (or JAK) with high disease: ASDAS>/=2.1
▶️Monoclonal TNF for uveitis/IBD, high PsO: IL-17
▶️Sustained remission: tapering of bDMARD "can be considered"
@RheumNow https://t.co/3yYU0Vb37r
TheDaoIndex KDAO2011
2 years 5 months ago
Proof that MTX doesn't affect sperm! Sperm morphology, motility, concentration, semen volume, testosterone/LH/FSH similar b/f and after exposure; DNA fragmentat'n was⬆️in pre-MTX exposure (possible reason high dz activity contributes to infertility) #EULAR2022 @rheumnow OP0131 https://t.co/JWLEggRhAY
Richard Conway RichardPAConway
2 years 5 months ago
Hamroun @annamolto et al. Factors assoc with increased time to conception in SpA. 56 pregnancies. Multivariate model, age (HR 1.22 (1.08-1.40)) and preconception NSAID use (HR 3.01 (2.15-3.85)) assoc increase time to conception. @RheumNow #EULAR2022 OP0153 https://t.co/y2EAyAdRmk https://t.co/28aLimRInE
TheDaoIndex KDAO2011
2 years 5 months ago
OP0129 Eudravigilance eval pregnancies exposed to non-TNF biologics compared certolizumab. Possible signal w/#vendolizumab: 3 cases of corpus callosum agenesis (2 Crohn’s, 1 UC, 2 assc w/ other CNS malformations). Belim did not show consistent pattern #EULAR2022 @rheumnow https://t.co/BNKaxu6G0c
Richard Conway RichardPAConway
2 years 5 months ago
Perez-Garcia et al. MTX effect on semen parameters. I still frequently get queries about this. 48 participants here. No significant effect! @RheumNow #EULAR2022 OP0131 https://t.co/33NG6isehm https://t.co/g7Xn33i96u
Md Yuzaiful Md Yusof Yuz6Yusof
2 years 5 months ago
#OP0142 #EULAR2022 Morand compared LLDAS in Early (<1yr) and Established #lupus. Although Early were younger & had higher disease activity, time-to-LLDAS was shorter. LLDAS was protective of flare in both. Should target for LLDAS early in diagnosis to improve outcomes @RheumNow https://t.co/7i9c69YkR3
TheDaoIndex KDAO2011
2 years 5 months ago
In people without SLE who have severe COVID19 infection, autoAb against IFN-1 assc w/increased mortality Prof T Dorner #EULAR2022 @rheumnow https://t.co/nt2gACUtkL
Richard Conway RichardPAConway
2 years 5 months ago
BIOBADASER Registry data on comparative drug-dependent cancer risk in patients with prior cancer. 352 patients. 32 incident cancers (14 NMSC). No difference between agents, but wide CIs @RheumNow #EULAR2022 OP0138 https://t.co/NEZSL2AQhC https://t.co/EG0NflXXW6
Richard Conway RichardPAConway
2 years 5 months ago
Unizony et al. Case series of tocilizumab + 8 weeks steroid in GCA. 30 patients, 50% new 50% relapsing. 77% in sustained remission at week 52! No vision loss. Exciting, needs an RCT @RheumNow #EULAR2022 OP0185 https://t.co/ohBYIWYxBC https://t.co/fsn4x17Hwv
Janet Pope Janetbirdope
2 years 5 months ago
#Behcets. If topical oracort / steroids don’t work for Mucosal ulcers consider topical #tacrolimus https://t.co/7ZiLfdwZoP
TheDaoIndex KDAO2011
2 years 5 months ago
New #SLE drug to pay attention to!
iberdomide target Ikaros and Aiolos, reduce B cell, reduce autoAb and reduce IFN sig while enhancing regulatory T cells- Prof T Dorner #EULAR2022 @rheumnow https://t.co/q39pxK3gFJ
Aurelie Najm AurelieRheumo
2 years 5 months ago
Spanish safety registry BIOBADASER 3.0:
*9000+ pts with IMID treated w/ bio or tsDMARDS
*352 pts w/ prior malignancy
*32 incident malignancies
-> 27 events/1000PY
NO diff between ttmts in incidence or mortality but low number pts in non TNFi groups
@RheumNow #EULAR2022
OP0138 https://t.co/8IyC6NdGCF