Does MTX have an impact on UST-immunogenicity in PsA? Post-hoc analysis from UST RCT in 110+ pts No difference in ADA rates & concentrations between MTX and non-MTX groups and ADA not associated w/ decreased UST levels POS0079 @RheumNow #EULAR2022 https://t.co/TA0YTx8qRT

#EULAR2022 ASAS/EULAR AxSpA Recs ⭐️Last: 2016 ▶️All: education, exercise, 🚭 ▶️❌csDMARD for axial disease ▶️TNF/IL17 (or JAK) with high disease: ASDAS>/=2.1 ▶️Monoclonal TNF for uveitis/IBD, high PsO: IL-17 ▶️Sustained remission: tapering of bDMARD "can be considered" @RheumNow https://t.co/3yYU0Vb37r

Proof that MTX doesn't affect sperm! Sperm morphology, motility, concentration, semen volume, testosterone/LH/FSH similar b/f and after exposure; DNA fragmentat'n was⬆️in pre-MTX exposure (possible reason high dz activity contributes to infertility) #EULAR2022 @rheumnow OP0131 https://t.co/JWLEggRhAY

Hamroun @annamolto et al. Factors assoc with increased time to conception in SpA. 56 pregnancies. Multivariate model, age (HR 1.22 (1.08-1.40)) and preconception NSAID use (HR 3.01 (2.15-3.85)) assoc increase time to conception. @RheumNow #EULAR2022 OP0153 https://t.co/y2EAyAdRmk https://t.co/28aLimRInE

• EULAR Abstract Archive

Perez-Garcia et al. MTX effect on semen parameters. I still frequently get queries about this. 48 participants here. No significant effect! @RheumNow #EULAR2022 OP0131 https://t.co/33NG6isehm https://t.co/g7Xn33i96u

• EULAR Abstract Archive

Patient with 12 weeks inflamm-sounding arthralgias and functional impairment, high titre RF/CCP, osteitis on MRI, no clinical synovitis on exam. Do you suggest to patient to treat with methotrexate? #EULAR2022 @RheumNow

🚨 Study on MTX and male fertility Analysis of semen parameters in 🙋🏼‍♂️HC 🙋🏼‍♂️RA, PsA and PsO MTX naive 🙋🏼‍♂️Post MTX Reassuring data as NO significant effect of MTX was observed on several semen parameters. #EULAR2022 @RheumNow OP0131 https://t.co/Fq32lzAMAx

Hamroun S et al for the GR2 Cohort showed that age HR 1.22 and use of NSAIDs HR 3.01 in the pre-conception period was associated with a longer time to conception in women with SpA. Research is needed on continuous NSAID use in the preconception period #EULAR2022 @RheumNow OP0153 https://t.co/hl6jUlK5PN

MIRACLE study: High or Low dose MTX w/ ADA in eRA? ✨ LOWd (6-8mg/w) 38.4% non-inferior to HIGHd (>10mg/w) 44.8% ✨But safety profile looks better 9.1% vs 22.1% 👀 Are you already looking for minimal dose of MTX in patients treated w/ biologics? #OP0062 @Rheumnow #EULAR2022 https://t.co/dq0EIKSnOe