Global Mortality Rates for PsA, SpA and Colitis Save

Global age-standardized mortality rate (ASMR) for 1000000 was for 0.13 for AS, 0.04 for PsA, 0.86 for CD and 0.76 for UC.

Using mortality data from the World Health Organisation (WHO), researchers showed that over time, while there has been no change in age-standardized mortality rates (ASMR) for patients with ankylosing spondylitis (AS), ASMR were decreased for IBD patients (Crohn's disease [CD] and ulcerative colitis [UC]).

Looking for temporal trends, mortality rates for spondyloarthritis and IBD patients were determine between 2001 and 2015.

Global mortality rates (ASMR) was:

• AS: 0.13 [0.11–0.14] deaths per million
• PsA: 0.04 [0.03–0.05] deaths per million
• CD: 0.86 [0.82-0.89] deaths per million
• UC: 0.76 [0.73-0.79] deaths per million

Between 2004 and 2015, there was no significant change in ASMR for AS, but for PsA, there was a significant increase in mean annual percent change (APC: 5.94%, p<0.001). Conversely, a time related significant decrease in APC (from 2001 to 2015) was seen for CD (mean APC: -0.82%, p<0.001) and UC (mean APC: -1.29%, p<0.001).  Moreover, they found significant geographical disparities in SpA and IBD mortality across the world.

While IBD patients have higher mortality numbers and PsA the least, do these changes reflect regression to a mean or the impact of drug development in the 11 year period under study?  More research is needed.