Are JAKi fulfilling their promises in RA? H Schulz-Koops said a survey showed rheumatologists wanted effective fast acting Rx that could be used as monotherapy. ⁦⁦@eular_org⁩ #EULAR2022 ⁦@RheumNow⁩ https://t.co/Gdel9YnAzA

VIGIBASE registry RA 39000+ pts JAKi and 231000+ pts TNFi *No increase in MACEs with JAKi 1.4% vs. 0.9% *JAKi Increase in DVT RR 3.99 and PE RR 3.5 adjusted on age and sex @RheumNow #OP0268 #EULAR2022 #Lupus https://t.co/hiAvKctgky

Some / most of promises of #JAKi are fulfilled. Efficacy, adherence = on mono vs combination Rx with MTX. But some emerging safety issues. NK cells reduce inflammation of NK cells on fibroblasts re other MOA. @eular #EULAR2022 ⁦@RheumNow⁩ The promise of #JAKi I RA https://t.co/8Ry3vVMyzO

#ClinicalPearl. Why do doctors prescribe #JAKi in RA? Efficacy, fast onset, X-ray inhibition, can work as monotherapy, remission - in order of diminishing frequency BUT I will add access and oral (convenience). POS0680 @RheumNow @eular_org #EULAR2022 https://t.co/XHtNqguqvh

JAK will quiet Still’s disease? 7 w Still’s 4 refractory disease had benefit w #JAKi POS0014. Needs more data but looks promising most w partial response . 5 on #Tofacitinib and 2 w #Baricitinib. ⁦@eular_org⁩ #EULAR2022 POS0014 ⁦@RheumNow⁩ https://t.co/j9IRgT9XJf

Insightful session with H Schulze-Koops: JAKi-Are all promises fulfilled? "JAKi have not shown us sufficient data to prove that they can induce remission or inhibit disease progression" @RheumNow #EULAR2022 https://t.co/SKKAS1ViIU

Meudec et al. Comparative effects of JAKi on NK cell function on cancer cells (lymphoma and lung cancer). Tofacitinib had most negative impact. Interesting given blanket black box based on tofa data! @RheumNow #EULAR2022 OP0265 https://t.co/XSE7hP60Ui https://t.co/MjtAJcvWAD

• EULAR Abstract Archive

Nyam et al. JAK-pot study. >90000 treatment courses. No difference in aHR for treatment stop due to adverse events in JAKi vs TNFi or non-TNF bDMARD. @RheumNow #EULAR2022 OP0266 https://t.co/3tgADvH1Bq https://t.co/2qLRzfMB9c

• EULAR Abstract Archive

Szekanecz et al. ORAL Surveillance. Geographic differences in MACE largely driven by history CVD and high baseline risk in North America and ROW. @RheumNow #EULAR2022 POS0110 https://t.co/cR6a7N2KP5