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Dr. John Cush RheumNow
2 years 5 months ago
GLORIA trial presented by Martin Boxers. 2 yr RCT, 5mg Pred vs. PBO shows DAS28 benefit (-0.37 to -0.62) & -1.7 better X-ray (vs PBO) at 2yrs. BUT signif more harm (AE) RR 1.24; mostly infx. Is this a good trade off? Abst# OP0263 #EULAR2022 https://t.co/kBiRYxXXZe
Md Yuzaiful Md Yusof Yuz6Yusof
2 years 5 months ago
#OP0247 #EULAR2022 Prof Mease analysed US Database (>1 million) pre- & post-Omicron using machine learning.Factors assoc with poor #COVID outcomes in IMID:age & comorbidities. Vaccination was protective. JAK-I and RTX increased risk weakly initially but not post-Omicron @RheumNow https://t.co/JCqTZvPgll
Aurelie Najm AurelieRheumo
2 years 5 months ago
Risk of haematological malignancy in PsA
Nordic cohorts
*40 events, IR 67/100 000 person-years
*NO difference between PsA bionaive and TNFi treated
BUT *⬆️ in PsA vs. matched controls
*no difference between myeloid and lymphoid malignancies.
OP0257 #EULAR2022 @RheumNow https://t.co/oIojobgDP3
Dr. Antoni Chan synovialjoints
2 years 5 months ago
Swedish study by Lindstrom U et al of over 3000 PsA patients matched with RA comparators showed that the length of time on MTX (PsA 4.5 and RA 4.4 years) before adding or switching to b/tsDMARD was identical in PsA (34%) and matched RA controls (33%) #EULAR2022 @RheumNow POS0073 https://t.co/Dwrz8RVMnh
David Liew drdavidliew
2 years 5 months ago
Can genetics solve all the world's problems with predicting response to therapy in rheumatology?
No - but maybe it can be a part of the solution?
Multi-domain apporaches (including good clinical data) needed to really have cut-through
@karolinskainst OP0267 #EULAR2022 @RheumNow https://t.co/wISPUB6m64
Md Yuzaiful Md Yusof Yuz6Yusof
2 years 5 months ago
#OP0248 #EULAR2022 In contrast to data from #OP0247 where SpA was protective, a matched population study in Canada found the opposite - increased risk of hospitalisation & death in SpA. A meta-analysis cd help to disentangle this @RheumNow https://t.co/keNZ2RPnXF
TheDaoIndex KDAO2011
2 years 5 months ago
New Tool! STAR (#Sjogren’s Tool for Assessing Response) was developed to assess treatment response in primary Sjogren’s and will be validated on 3 datasets #EULAR2022 @rheumnow OP0286 https://t.co/9tgVSWGxEc
Aurelie Najm AurelieRheumo
2 years 5 months ago
Izokibep Phase 2 in active PsA at Wk 16 results (80mg dose):
⭐️ACR50 52%
⭐️PASI 90 50%
⭐️Resolution of enthesitis LEI 88%
⭐️Safety profile similar to what observed in PsO.
Promising for the enthesitis domain!
@RheumNow OP0258 #EULAR2022 https://t.co/Wm3MvVQzoP
Richard Conway RichardPAConway
2 years 5 months ago
Dr Singh @NamrataRheum et al. VA study of lymphoma risk with b/tsDMARDs. No increased risk found. HR adjusted time-fixed and time-varying covariates vs csDMARD 1.04 (0.80-1.35) @RheumNow #EULAR2022 POS1434 https://t.co/B6ENz805yl
Md Yuzaiful Md Yusof Yuz6Yusof
2 years 5 months ago
#OP0251 #EULAR2022 Any data to support association of RA-ILD with poor #COVID outcomes? A study is US >500 pts (9% ILD) showed ILD as well as poor RA status (RF+ & erosion) increased risk. Detailed analysis inc Radiographic + PFT cd help stratify risk further @RheumNow https://t.co/E89dd38GQS
Eric Dein ericdeinmd
2 years 5 months ago
#EULAR2022 OP0276: What do patients want for preventative interventions for RA?
⭐️Survey of 1st degree relatives of RA pts (at risk) vs general pop were similar
⭐️'Hypothetical' treatment profile best aligned to abatacept
@Rheumnow https://t.co/r4y7SZbjTA
Richard Conway RichardPAConway
2 years 5 months ago
Montastruc et al. VigiBase study of CV and VTE events in JAKi vs TNFi. >270000 events. DECREASE in MACE ROR=0.87 [95%CI 0.80-0.95]. INCREASE in DVT: ROR=3.99 [3.15-5.04], PE: ROR=3.47 [2.90-4.13] @RheumNow #EULAR2022 OP0268 https://t.co/lUin7ciXWt https://t.co/Gr4Kvd8F7R
Aurelie Najm AurelieRheumo
2 years 5 months ago
Survival of RA-ILD pts w/ lung 🫁 transplantation
Retrospective single centre study
*Mortality 36%
*Usual Interstitial Pneumonia worst prognosis w/ HR 7.13 (did not reach significance, small cohort)
*Survival time comparable to other lung Tx cohorts
#EULAR2022 OP0275 @RheumNow https://t.co/LslPxyXJCp
TheDaoIndex KDAO2011
2 years 5 months ago
OP0285 Voclosoporin effective in #lupusNephritis from AURA-LV and AURORA1 to achieve EULAR/ERA nephritis targets (proteinuria < 0.7 mg/mg and pred < 7.5 mg/d) at 1 year @AuriniaPharma #EULAR2022 @rheumnow https://t.co/0GoCgP98F2
David Liew drdavidliew
2 years 5 months ago
MACE in JAKi vs TNFi: did spontaneous reporting pharmacovigilance pick it?
Vigibase: MACE (really MI) & VTE signals there before the scare
Always chance regulatory warnings cause stimulated reporting
but signal here was clear before RCT-driven alerts
OP0268 #EULAR2022 @RheumNow https://t.co/hTJD1gMgyy
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