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Septic arthritis MIMICs (all presenting as acute monoarthritis) - consider: cellulitis, bursitis, abscess, osteonecrosis, gout, pseudogout, Lyme, Osteomyelitis, reactive arthritis, Lyme disease,, Rheumatoid arthritis, & Transient synovitis (kids) https://t.co/uNirAcoBds

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Dr. John Cush RheumNow ( View Tweet)

2020 Year Review

ICYMI: 2020 Rheumatology Year in Review

d Jack Cush, MD

2020 was historic, memorable and game-changing. Under the cloud of COVID-19, there were many significant and memorable advances and setbacks for the rheumatology world. In our accounting of most read articles for 2020, (not surprisingly) 17/20 were COVID-related.

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ProDERM Study: IVIG in Dermatomyositis--The ProDERM study show that IVIg is safe, effective and superior to placebo in patients with dermatomyositis (DM). https://t.co/HOB8CYn9yc https://t.co/4nNRRhzHVO

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Dr. John Cush RheumNow ( View Tweet)
ProDERM OP0008: IVIG 2g/kg q4w for dermatomyositis vs PBO, open-label extension. TIS score responders 78% vs 43%. IVIG great option: Not immunosuppressive and works fast, watch for headache, pyrexia, nausea, risk of VTE. #EULAR2021 @RheumNow https://t.co/m4CEkg3EyC
Eric Dein ejdein1 ( View Tweet)
ProDERM study (95 pts): RBPCT phase III IVIG 10% is effective in dermatomyositis (2 g/kg over 2-5 days q4 weeks. (common AEs: HA, fever, nausea most common AEs, rare SAE include thrombosis, LoC, hypoesthesia). Dr. R Aggarwal Abstr#OP008 #EULAR2021 @RheumNow https://t.co/ScTdUySxOl
k dao KDAO2011 ( View Tweet)
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RheumNow Podcast – BandAids for Rheumatologists (5.14.2021)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com - a website for rheumatologists, by rheumatologists.



We love Rheumatology!

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pompe myopathy glycogen muscle

New, Improved Therapy for Pompe Disease

d Jack Cush, MD

Researchers from the University of Cincinnati Gardner Neuroscience Institute will present data on a new treatment for Pompe disease at the American Academy of Neurology on April 20th; the results show that treatment with avalglucosidase alfa yielded substantial clinical improvements and a more favorable safety profile compared to the current standard of care (alglucosidase alfa).

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RheumNow Podcast – Combination Biologics

d Jack Cush, MD

Dr. Jack Cush serves up this week's news and articles from RheumNow.com.

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RheumNow Podcast – Upadacitinib Wins in PsA (4.2.2021)

d Jack Cush, MD

Dr Jack Cush reviews the news and Journal reports and takes "Back Talk" questions from viewers.

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2127 suspected myositis patients assayed for myositis Abs, ~1% tested positive for SAE Abs (small ubiquitin-like modifier (SUMO) activating enzyme) - present w/ rash first, followed by myositis, extramuscular involvement, sm risk for coincident cancer https://t.co/1f0GTcpdIo

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Dr. John Cush RheumNow ( View Tweet)

News Feature: MDA-5 Antibodies and Juvenile Dermatomyositis https://t.co/vxyXZyO0gs https://t.co/GgzhnhlmdR

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Dr. John Cush RheumNow ( View Tweet)
labs2.jpg

MDA-5 Antibodies and Juvenile Dermatomyositis

d Jack Cush, MD

A multicentre, retrospective study examined MSA profiles (by immunoprecipitation) from 96 juvenile idiopathic inflammatory myopathies (JIIM) at nine pediatric rheumatology centres in Japan. MSA were found in 85 of 96 cases with over 90% of patients having one of the following three MSA

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RheumNow Podcast – Sweet Lies or Hard Truths? (2.26.2021)

d Jack Cush, MD

Dr. Jack Cush reviews and discusses the news and Journal reports from the past week on RheumNow.com.

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Other than anti-tRNA synthetase Abs, there are several new Abs associated with PM/DM @UTSWNews @UTSWInternalMed https://t.co/EttRB3YYHm
Dr. John Cush RheumNow ( View Tweet)
Classic path findings in dermatomyositis @UTSWNews @UTSWInternalMed https://t.co/W61OveDSwG
Dr. John Cush RheumNow ( View Tweet)
An unsual type of adult polymyositis that is not usually steroid responsive - Polymyositis with mitochondrial abnormalities - older patients +COX staining, slow progression. @UTSWNews @UTSWInternalMed https://t.co/2tv1R3e9Qg
Dr. John Cush RheumNow ( View Tweet)
Rheumatology Grand Rounds with Dr. Dennis Burns - lecturing on neuropathology of inflammatory myositis. Not all Muscle Bxs are positive, estimated sampling error w/ normal findings in 10-15% @UTSWNews @UTSWInternalMed https://t.co/Xm73GuMa3j
Dr. John Cush RheumNow ( View Tweet)
High Risk Cancer Profiling with Inflammatory Myositis A recent metanalysis of studies suggest you may be able to use certain clinical factors to stratify cancer risk in patients with idiopathic inflammatory myopathies (IIMs). https://t.co/TjmdGtdDQG https://t.co/tlfVU031fY

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Dr. John Cush RheumNow ( View Tweet)
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High Risk Cancer Profiling with Inflammatory Myositis

d Jack Cush, MD

A recent metanalysis of studies suggest you may be able to use certain clinical factors to stratify cancer risk in patients with idiopathic inflammatory myopathies (IIMs).

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RheumNow Podcast – Don’t Hold the Benlysta, Take the Vaccine (1.22.2021)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com, with more than a dozen items to discuss on this week's podcast.

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