Simon Says “Don’t Do This” (1.27.2022) Save

Dr. Jack Cush reviews this week’s journal articles, focuses on studies that should not have been done and responds to viewer questions in Ask Cush Anything.

1. "Dry Synovitis" exist in juvenile arthritis pts? Study of 12 DS pts, says its different from Poly #JIA; onset 6.1 yrs, w/ polyarthritis, no palpable swelling, progressive LOM/contractures, neg ESR/CRP/RF/CCP, +MRI synovitis w/ osteochondral involvement. https://t.co/tL2G7QKBL4

2. PRedSS was a small trial of 35 pts with early diffuse systemic sclerosis Rx w/ prednisolone(17) vs placebo(18). At 3 mos outcomes favored Pred, but nonsignificant (HAQ-DI -0.10; p= 0.25 & mRSS -3.90; p= 0.07), but less pain & anxiety https://t.co/iZw2L9SLhF

3. 702 #SLE pts (age 29 yrs) from India, measured plasma 25-hydroxyvitamin-D(25(OH)D) - median levels were 22.83 (13.8–31.8) ng/ml. Low Vit D(< 20) seen in 41.5%; correlated w/ age/geography, & weak neg correlation w/ weak negative correlation w/ SLEDAI2K https://t.co/EUPqJGKAhI

4. JAMA: 13 million In US have latent TB (5-10% risk of getting active TB). Review of LTBI regimens: - Preferred: 4 mos Rifampin: better/safer of INH - Preferred: 3 mos of INH + rifapentine - more completers less SAE - ALternative: 6-9 mos of INH https://t.co/vZTmSKTFWu

5. JAK-pot Study: To Cycle or Switch after JAK inhibitor Failure?  https://rheumnow.com/news/jak-pot-study-cycle-or-switch-after-jak-inhib…

6. Variable Pregnancy Outcomes with Belimumab in SLE  https://rheumnow.com/news/variable-pregnancy-outcomes-belimumab-sle

7. ASK CUSH ANYTHING  

   1. FM/a Test for Fibromyalgia?

   2. What to do about CKemia with JAK inhibitors?

   3. Use TNF inhibitors in PsA with melanoma insitu?

8. RheumNow.Live - Early Bird registration ends on Jan 31st - register now