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Spondyloarthritis

Strike First: TNFi vs. Step-Up Therapy in Early Peripheral SpA The approach to treating peripheral SpA has remained the same for a long time. The guidelines recommend starting with NSAIDs, escalating to conventional synthetic DMARDs, typically sulfasalazine or methotrexate, and https://t.co/iEqzp6FStv
Dr. John Cush @RheumNow( View Tweet )
Strike First: TNFi vs. Step-Up Therapy in Early Peripheral SpA The approach to the treatment of peripheral SpA has been the same for a long time. The guidelines recommend starting with NSAIDs, escalate to conventional synthetic DMARDs, typically sulfasalazine or methotrexate and https://t.co/pG9dGSfgcP
Dr. John Cush @RheumNow( View Tweet )

New Oral Option for axSpA: Filgotinib for Radiographic and Non-Radiographic Disease

The Janus kinase inhibitor (JAKi) class has been increasingly used in the management of axial spondyloarthritis (axSpA) over the past five years, offering effective oral alternatives to injectable biologics. But are all JAK inhibitors the same?

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The pain that inflammation does not explain in SpA and PsA At EULAR 2026, the NEUPIA study (OP0317), a prospective observational investigation conducted at KU Leuven and University Hospitals Leuven, provides the most detailed longitudinal characterisation to date of these https://t.co/OYMf4KKBc1
Dr. John Cush @RheumNow( View Tweet )
๐Ÿ  Take Home Messages from the early #axSpA session ๐Ÿ”บ Earlier diagnosis is possible and better ๐Ÿ”บ Early axSpA is not synonymous to mild ๐Ÿ”บ Longitudinally, early axSpA is heterogeneous ๐Ÿ”บ MRI has transformed the field โ—๏ธBeware of pitfalls #EULAR2026 @RheumNow https://t.co/IhGQSxssyd
Nelly ZIADE ๐Ÿ€ @Nellziade( View Tweet )

Day 4 EULAR Report

The last day in London was exciting as both the Late-Breaking abstracts and new EULAR guidelines were presented. Guidelines presented addressed several significant unmet need areas including PMR, GCA, Takayasuโ€™s arteritis, Vaccinations in Rheumatic patients, Imaging in spondyloarthritis and

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Patient-initiated telemedicine follow-up cut rheumatology visits by 25% in stable #SpA, but not equally for everyone. Reductions were greatest in men, axSpA, bDMARD users, and the oldest patients (64+, 34% fewer visits). Patient-centered care delivery @RheumNow #EULAR2026 POS1345

Jiha Lee @JihaRheum( View Tweet )

SELECT-Axis 2 trial and Withdrawal of Upadacitinib - Of 734 pts, 194 were in remission at wk104--> UPA w/d & 22% maintained drug-free remission for >48wks. Rest flared, median time to flare: 3.1 mos (89% regained LDA by wk24 w/ restart) #EULAR2026 #axSpA POS1350 https://t.co/7A7CAHxLxX
Dr. John Cush @RheumNow( View Tweet )
Risk of Parkinsons? RA patients have 28% lower Parkinson's risk vs general population (HR 0.72); axSpA had HIGHER risk (HR 1.29). Non-TNF biologics in RA reduced PD risk further (HR 0.74). No effect seen in PsA/axSpA. #EULAR2026 Abstr #POS1116 https://t.co/1vZoZGEu5Z
Dr. John Cush @RheumNow( View Tweet )
๐Ÿ  Take Home Messages from the early #axSpA session ๐Ÿ”บ Earlier diagnosis is possible and better ๐Ÿ”บ Early axSpA is not synonymous to mild ๐Ÿ”บ Longitudinally, early axSpA is heterogeneous ๐Ÿ”บ MRI has transformed the field โ—๏ธBeware of pitfalls #EULAR2026 @RheumNow

Nelly ZIADE ๐Ÿ€ @Nellziade( View Tweet )

A high proportion of juvenile-onset SpA progress toward a r-axSpA phenotype Results from the Spanish REGISPON-3 POS1352 #EULAR2026 @RheumNow https://t.co/XicguAdXJ1
Nelly ZIADE ๐Ÿ€ @Nellziade( View Tweet )
How many patients with IBD have axSpA? POS1338 #EULAR2026 @RheumNow โฌ‡๏ธโฌ‡๏ธโฌ‡๏ธ https://t.co/29qkrCnDYz
Nelly ZIADE ๐Ÿ€ @Nellziade( View Tweet )
Is the risk of uveitis comparable between infliximab sc and adalimumab in patients with r-axSpA and prior AAU? Yes! POS 1347 Multicenter randomised open-label trial N=56 #EULAR2026 @RheumNow https://t.co/kP7ropPkpC
Nelly ZIADE ๐Ÿ€ @Nellziade( View Tweet )
What happens after withdrawal of upadacitinib in patients with axSpA who achieved remission? Data from 194 patients from the SELECT-AXIS2 RCT: โ–ถ๏ธ Remission maintained in 1/4 at48 weeks POS1350 #EULAR2026 @RheumNow https://t.co/Z7nDwMuQux
Nelly ZIADE ๐Ÿ€ @Nellziade( View Tweet )
#EULAR2026 LB0002 More great news for dual IL17A and -F blockade. An open label Phase II study of Sonelokimab, a novel IL-17A- and IL-17F-inhibiting Nanobody'-3 in #axSpA: clinical efficacy, improvement in PROM and imaging inflammation. Looking forward to the RCT phase @RheumNow https://t.co/Xtxa8fALzN
Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
#antisynthetase #EULAR/ACR #classification #criteria #EULAR2026 @RheumNow Based on >2k pts Probable v definite Ignore low + #synthetase #antibodies Seems reasonable and applicable โžก๏ธmy opinion https://t.co/MyCRiCSiGo
Janet Pope @Janetbirdope( View Tweet )
LB0002: Sonelokimab (IL-17A/F Nanobody, ~40 kDa) in #axSpA Phase 2: 81% ASAS40 and 54% ASAS partial remission at 12 weeks. Mean ASDAS improvement of โˆ’2.0 from baseline. @RheumNow #EULAR2026 https://t.co/TjvtnFPCdj
Antoni Chan MD (Prof) @synovialjoints( View Tweet )

New: Classification Critiera and Recommendations in SpA

2026 EULAR Press Release

ASAS and the SPARTAN have updated their key classification criteria for axial SpA (axSpA). EULAR has also recently revised their recommendations on the role of imaging in the diagnosis and clinical management of spondyloarthritis (SpA). Both were presented at the EULAR 2026 annual Congress in

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Even with tight T2T, ARCTIC 10yr follow-up (n=170) show 9% had RA-ILD on HRCT, plus another 19% with non-specific interstitial findings. Male sex and older age were risk factors. Seropositivity was not. Vigilance remains essential. @RheumNow #EULAR2026 POS1270

Jiha Lee @JihaRheum( View Tweet )

Strike First: TNFi vs. Step-Up Therapy in Early Peripheral SpA

The approach to the treatment of peripheral SpA has been the same for a long time. The guidelines recommend starting with NSAIDs, escalate to conventional synthetic DMARDs, typically sulfasalazine or methotrexate and reserve biologics for patients who fail those. According to a new phase 3 trial

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Which b/tsDMARDs are effective in #axSpA? Stratified by extramusculoskeletal manifestations Check out the latest update of the treatment heatmap ๐Ÿ”ฅ By Astrid van Tubergen At axial and peripheral SpA at a crossroads session #EULAR2026 @RheumNow https://t.co/uTxEJqbDBm
Nelly ZIADE ๐Ÿ€ @Nellziade( View Tweet )
Which b/tsDMARDs are NOT effective in #axSpA? Check out the latest update of the treatment heatmap ๐Ÿ”ฅ By Astrid van Tubergen At axial and peripheral SpA at a crossroads session #EULAR2026 @RheumNow https://t.co/hqfLAYeri3
Nelly ZIADE ๐Ÿ€ @Nellziade( View Tweet )
Key messages in the tx of ax/p-SpA: >csDMARDs only effective in pSpA >consider individualized treatment for bDMARDs and JAKis >Cycling TNFi equally effective to switching @RheumNow #EULAR2026 https://t.co/oeO3BxmYYo
Which b/tsDMARDs are effective in #axSpA? Check out the latest update of the treatment heatmap ๐Ÿ”ฅ By Astrid van Tubergen At axial and peripheral SpA at a crossroads session #EULAR2026 @RheumNow https://t.co/8mj24lAOTk
Nelly ZIADE ๐Ÿ€ @Nellziade( View Tweet )
What b/ts DMARDs are effective and not effective in axSpA? Prof. Astrid van Tubergen presents this very informative summary slide summarizing treatment in axSpA. @RheumNow #EULAR2026 https://t.co/5udGPB1Hrr
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