Autoinflammatory

šŸ”„ Stillā€™s Disease Awareness Day 2026 šŸ‰ I Wonā€™t Be Still: Making Stillā€™s Disease Visible Show us a moment from your life with Stillā€™s Disease. šŸ“ø Share a photo/video + what ā€œI Wonā€™t Be Stillā€ means to you. For 47 hours, letā€™s make Stillā€™s visible. #MyStills #StillsDay https://t.co/B7VNmlIOQj

Links:

AiArthritis @IFAiArthritis( View Tweet )
šŸ†• #AutoInflammatory / Periodic Fever Syndromes In Memory of Dr. Dan KastneršŸ•Šļø So grateful Dr. Kastner agreed to review this graphic >1 year ago, providing thoughtful input and suggestions to improve the final version šŸ™ New Board Review Series for Rheum OnePagers šŸ“Ÿ #RheumX https://t.co/zx8dX2yHkA

Links:

Mithu Maheswaranathan, MD @MithuRheum( View Tweet )
Misdiagnosis of Still's Disease High fever, strange rashes, scary labs often lead to a consideration of Still's disease (AOSD or systemic JIA). Yet the dramatic onset of a systemic disorder may overlap with another, and possibly rarer, systemic disorder that should not be https://t.co/pSfSahO5Nw
Dr. John Cush @RheumNow( View Tweet )
Misdiagnosis of Still's Disease High fever, strange rashes, scary labs often lead to a consideration of Still's disease (AOSD or systemic JIA). Yet the dramatic onset of a systemic disorder may overlap with another, and possibly as rare, systemic disorder that should not be https://t.co/mCbNBAt9T5
Dr. John Cush @RheumNow( View Tweet )
Fever,temp,man,HA,thermometer

Misdiagnosis of Still's Disease

Jack Cush, MD

High fever, strange rashes, scary labs often lead to a consideration of Still's disease (AOSD or systemic JIA). Yet the dramatic onset of a systemic disorder may overlap with another, and possibly as rare, systemic disorder that should not be misdiagnosed or mistreated. A current case review by

Read Article
Substudy of 131 Stillā€™s dz pts from the Autoinflammatory Dz (AIDA) registry. 38% underdosed w/ canakinumab (CAN) vs 62% appropriately dosed (300 mg q4wks or 4 mg/kg). Underdosed CAN had lower odds of long-term remission & D/C CAN (3.9% vs 19%) https://t.co/l94zB9NkKv https://t.co/FQTrCWZLQI

Links:

Dr. John Cush @RheumNow( View Tweet )
RheumNow Podcast square

Doubting RS3PE (8.14.2026)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles this week where RheumNow featured info on cancer, deadly viruses, AI rules, poetry and good moons rising.

Read Article
cardiac2.jpg (keep)

ZEUS Trial: IL-6 Inhibition Fails to Cut Cardiovascular Events

Jack Cush, MD

The phase 3 ZEUS trial (published in JAMA Dec. 2025)  tested the IL-6 ligand inhibitor ziltivekimab in over 6,000 patients with atherosclerotic cardiovascular disease, chronic kidney disease, and elevated hsCRPā€”a population enriched for an inflammatory driver of risk.

Read Article
Substudy of 131 Stillā€™s dz pts from the Autoinflammatory Dz (AIDA) registry. 38% underdosed w/ canakinumab (CAN) vs 62% appropriately dosed (300 mg q4wks or 4 mg/kg). Underdosed CAN had lower odds of long-term remission & D/C CAN (3.9% vs 19%) https://t.co/l94zB9NkKv https://t.co/D8FNUXS0nv

Links:

Dr. John Cush @RheumNow( View Tweet )
RheumNow Podcast square

Mentshlichkeit* (8.7.2026)

Jack Cush, MD

Dr. Jack Cush reviews the news and recent journal reports on RheumNow.com.

Read Article
Retrospective study, 41 pediatric Behcets Dz pts looked at Inflam. indices (NLR, SII, PIV, CRP/albumin) vs controls. BD systemic involvement in 68%, CNS dz in 10%, Vascular Dz in 12% & major organ dz 46%. Inflamm indices significantly higher in BD w/ systemic, CNS, & Vasc https://t.co/wHiBIaOWWU
Dr. John Cush @RheumNow( View Tweet )
Dan.Kastner

A Tribute to Daniel L. Kastner, MD, PhD (1951ā€“2026)

Jack Cush, MD

The rheumatology, genetics and NIH communities mourn for Dr. Daniel L. Kastner, who died on July 28, 2026, in Bethesda, Maryland, at age 74. The following are declarations, tributes, and memories dedicated to this mensch of a man, titan of science, memorable mentor and humble physician.

Read Article
pediatric.kid_.jpg

$2 Million in Research Grants for Juvenile Arthritis

Jack Cush, MD

July is Juvenile Arthritis Awareness Month, and while many people think of arthritis as a disease of aging, nearly 300,000 children in the U.S. are living with a rheumatic disease.

Equally important is that 2026 marks a 50 year anniversary for Pediatric

Read Article
Chinese cohort of 209 AOSD pts identifed 49 (23%) w/ lung dz (by CXR), yet 69% were asymptomatic. Significcant risk factors for AOSD-LD were pleuritis, MAS (HRā€‰2.62), & Dz relapse (HRā€‰2.6). Imaging patterns: acute exudative pattern most prevalent, followed by interstitial and https://t.co/2IPJWRJicP
Dr. John Cush @RheumNow( View Tweet )
RheumNow Podcast square

Chikungunya Club Meeting (7.24.2026)

Jack Cush, MD

Dr. Jack Cush reviews the news, journal reports from the past week on RheumNow.com.

Read Article
51 yoM w/ 2 yrs of FUO, unintentional 32-kg wt loss, LN, diffuse myalgias, but no GI Sxs or arthralgia. Neg MRIs, CT, PET scan, EGD, colonoscopy. Abnl labs: CRP 173 mg/L, ESR 46, anemia & ^ WBC. Cell-free DNA next-generation sequencing dx Tropheryma whipplei, & Whipple disease https://t.co/nJLa4l7Ers
Dr. John Cush @RheumNow( View Tweet )
2 Still's dz cohorts (96 Shanghai, 28 Erlangen0 compared response to biolgics vs DMARDs (MTX, CNI,JAKi). in 124 AOSD pts, biologic had more sustained event-free remission and event-free state (Pā€‰0.0065, Pā€‰0.0096) & more steroid D/C vs MTX/CNI (pā€‰<ā€‰0.05). https://t.co/lJaI9nhPYr

Links:

Dr. John Cush @RheumNow( View Tweet )

RheumNow Podcast square

Gout Cavalcade (7.10.2026)

Jack Cush, MD

Dr. Jack Cush reviews the news, journal articles and regulatory decisions from the past week. July is Gout: More than Flares month.

Read Article
ICYMI: VEXAS Syndrome - A Review Beck et al has published a review of the VEXAS syndrome in The Lancet, focusing on the pathogenesis, spectrum, and treatment strategies. https://t.co/K9IMLBdCGI https://t.co/LJdnRflzsU

Links:

Dr. John Cush @RheumNow( View Tweet )
From Cytokine Endotypes to Clinical Reality in Stillā€™s Disease Recent EULAR 2026 data highlight a paradigm shift in Stillā€™s disease from syndromic management to biologically informed precision therapy. https://t.co/fBtkDLPJNE https://t.co/y8NBW6VHHa

Links:

Dr. John Cush @RheumNow( View Tweet )
From Cytokine Endotypes to Clinical Reality in Stillā€™s Disease Recent EULAR 2026 data highlight a paradigm shift in Stillā€™s disease from syndromic management to biologically informed precision therapy. https://t.co/FrghBJdlXj https://t.co/CbHYDKbnK9

Links:

Dr. John Cush @RheumNow( View Tweet )
Stills,continuum

From Cytokine Endotypes to Clinical Reality in Stillā€™s Disease

Bella Mehta, MBBS, MS

Recent EULAR 2026 data highlight a paradigm shift in Stillā€™s disease from syndromic management to biologically informed precision therapy.

Read Article
Eular stage

Whatā€™s New in Macrophage Activation Syndrome Therapeutics

Bella Mehta, MBBS, MS

MAS, the most severe complication of Stillā€™s disease, is increasingly recognized as a cytokine-driven hyperinflammatory state centered on interferon gamma (IFNĪ³). Therapeutic advances presented at EULAR 2026 demonstrate both consolidation of established pathways and expansion into novel biologic

Read Article
Emapalumab in MAS secondary to stills disease 39 pts, median age 12, 2 pooled prospective, open label, single arm studies. Endpoint complete resolution at week 8-. Around 60% and partial resolution nearly 100% 67% had concomitant anakinra @RheumNow ##EULAR2026 #EULARBest https://t.co/sGm43C3LfH

Links:

Bella Mehta @bella_mehta( View Tweet )
Window of opportunity in stills disease is early. With IL1 / IL6 agents #sJIA and #AOSD are the same disease. - may need a standard new crieteria IL18 measuremnet should be encouraged. @RheumNow #EULAR2026 plenary https://t.co/EQbs9mDYjS

Links:

Bella Mehta @bella_mehta( View Tweet )

Therapeutic Updates

Solving Still's Disease

RheumNow
Solving Still's Disease
Dr. Jack Cush reviews the history, manifestations, diagnosis and treatment of Still's disease.
Read Post

Recent Blogs

Advanced Practice Rheum

Still's Disease and Fever

Jack Cush, MD
Stills apr video cover
Dr. Jack Cush reviews Still's disease and fevers.
Read Article
Advanced Practice Rheum

Evaluation of Rheumatic Complaints

Jack Cush, MD
Eval of Rheum Complaints Cover Image
Dr. Cush provides a systematic approach to evaluating musculoskeletal and rheumatic complaints in clinical practice.
Read Article

Best of 2022: Five Mistakes When Diagnosing Stillā€™s Disease

Jack Cush, MD
Thermometer
Adult-onset Still's presents an interesting and diagnostic challenge when encountered. Here are 5 tips to improve your diagnostic acumen for this febrile disorder.
Read Post
How well do you know this week's rheumatology news?
Take the rheumIQ quiz
Take the RheumIQ Quiz

Podcasts

  • ACR 2025 Daily Podcasts Day2d
  • AOSD - Adult - Onset Still's Disease 00:33:08
  • ACR Fireside Chats - Still's disease Abstracts 00:22:48
×