Basic Sci Yr in Rvw #ACR26 Role of EBV+ B cells in SLE- resistant to killing w anti-CD20 and CD19 Ab Acute depletion leads to B cell reconstition without immune reset CD-19 CAR-T can effectively resent EBV+ B cells @RheumNow https://t.co/fs30bpjWWF

Basic Sci Yr in Rvw #ACR26 Pyrin ligand: CDC42 binds B30.2 MEFV gene in Med Fever lie in B30.2 CDC42-opathy joins IL-1 responsive autoinflamm diseases VEXAS- 2 mech from UBA1 Met41 mutations 1. Mutant macrophages die by apoptosis, necroptosis 2. Unfolded prot response @RheumNow https://t.co/ki1jSZnJIu

YIR: Why does RA affect PIPs and not DIPs? This study demonstrates that Joint-specific susceptibility is established embryonically: PIP jts - larger synovial vol & PI16+ fibroblasts Implications? Provides developmental exp why particular jts are affected @RheumNow #ACR26 https://t.co/easfYOl5Ee

Role of OA in HTN? Basic Sci Yr in Rvw #ACR26 HTN fuels OA via Arginine Vasopressin (AVP)-AVPR1A HTN associates w OA incidence/severity OA-primed chondrocytes upregulate AVPR1A - dri2ves cartilage catabolism Damage reversible @RheumNow https://t.co/j1AELAntLQ

YIR: This study fr Dr. W Robinson show that activated-naive autoreactive B cells expand before clinical arthritis Clinical implications? Potential target for RA prevention. @RheumNow #ACR26 https://t.co/uIG3kTIBzV

Basic Sci Yr in Rvw Pre-clinical RA: senescent-like activated B cells expand before clinical RA, present citrullinated Ag 2 seqen stages: 1. Type 1 IFN stage BEFORE subclinical syn 2. Cytotoxic GZMB+ stage Type 1 IFN affects nociceptors -> pain before arthritis @RheumNow #ACR26 https://t.co/VGAQuC0G1X

#CHAI has #AI that is the largest not for profit organization in #healthcare #keynote @ACRheum #ACR26 Example of #artificial #intelligence involves targets for #CAR-T #CD19, #CD20, #CD22 and #BCMA @RheumNow https://t.co/ZCENzmnNTN

"Implicit cognitive bias not only is unfair but also leads to worse patient outcomes" -Laure Gossec-Incoming EULAR president. Implicit bias (brain predicts before finishing listening) from healthcare providers affects pain assessment and management. Education is the way to https://t.co/7zWODNZWdd

#Vaccinate your #SARD Pts esp if given strong #immune #suppression #Taiwan #College of #Rheumatology #recommendations for #vaccines Pre & Post #CAR-T Can apply for #IMMUNESUPPRESSED Pts in general who get #B #cell #depletion #ACR26 abst#2773 @RheumNow https://t.co/34xcBjsD99

Immune-Related Adverse Events: ICI-IA: the most common rheumatic irAE-> Heterogeneous presentation. 50-78% persist >6m after stopping ICI. Usually seronegative and have elevated inflammatory markers. ICI-PMR: some pt with peripheral inflammatory arthritis, less likely comorbid https://t.co/Ad5FPGZ8nP

Importance of genetics in rheumatic diseases #ACR26 #ReviewCourse @RheumNow https://t.co/weDtEQH0Cb