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ACR 2026 – Day 1 Report
ACR Convergence was off to a big start with the year in review, posters and plenary sessions. Here are a few of our favorite presentations from today's Plenary I session at ACR Convergence. 2/5 plenary abstracts focused on weight loss, one on artificial https://t.co/d1u0nElhov
Dr. John Cush @RheumNow ( View Tweet )
10 minutes 33 seconds ago
Cytopenias in SLE - could be disease, but also our meds
Most associated with lymphopenia:
- RTX
- Tacro
- AZA
- MTX
MMF not associated w lymphopenia
RTX also associated w neutropenia
@rheumnow #ACR26 https://t.co/HmXXZWaUpJ
Brian Jaros, MD @Dr_Brian_MD ( View Tweet )
31 minutes 59 seconds ago
Late breaking, ICONIC PsA 1: icotrokinra, a once daily oral peptide targeting the IL23 receptor, in biologic naive PsA. Week 16 ACR20 58% vs 41% with placebo; ACR50 29% vs 16%; clear or almost clear skin 57% vs 14%. Key finding: the primary endpoint was met, with ACR20 69% and
Antoni Chan MD (Prof) @synovialjoints ( View Tweet )
32 minutes 2 seconds ago
CDAI remission does not describe every symptom. In a 787-patient RA study, those in remission still had meaningful pain interference (19%), fatigue (20%) and impaired function (23%). PROMIS scores show symptoms that composite score missed. #2874 @Rheumnow #ACR26
Mrinalini Dey @DrMiniDey ( View Tweet )
32 minutes 3 seconds ago
In 1,602 patients in the Brazilian Registry of Spondyloarthritis, moving from ASAS 2009 to ASAS SPARTAN 2025 removed 74 axSpA patients and added none. Only 39.2% of those removed had sacroiliitis on imaging, and they more often had psoriasis, IBD, female sex and later symptom
Antoni Chan MD (Prof) @synovialjoints ( View Tweet )
32 minutes 6 seconds ago
Accdg to this study, milk composition - macronutrients - of pts with SARDs was comparable to controls.
Key takeaway? Counsel mothers w/ SARDs and advocate for breastfeeding.
@RheumNow #ACR26 Abs2458 https://t.co/2JclXSYRJi
sheila @RHEUMarampa ( View Tweet )
32 minutes 7 seconds ago
Are gout flares causative of cardiovascular events (CVE)?
Hypothesis: systemic inflammation -> cardiac events
Timing correlation seen in observational studies
Post-hoc analysis CARES suggests maybe not...
Pt w/ CVE w no higher odds of gout flare
@rheumnow #ACR26 Abst1820 https://t.co/m1jWLAAanG
Brian Jaros, MD @Dr_Brian_MD ( View Tweet )
32 minutes 10 seconds ago
How well does PREVENT predict HF and total CVD in lupus?
Abst 2861 found:
- Moderate discrimination for both outcomes (C=0.70 each)
- Sensitivity of 53% for HF and 67% for total CVD
- PREVENT underestimated both risks across deciles
#ACR26 @RheumNow
Akhil Sood MD, MS @AkhilSoodMD ( View Tweet )
32 minutes 13 seconds ago
Who with oligoarticular PsA progresses to polyarticular disease?
Risk factors:
- 4 active joints
- F sex
- enthesitis
- swollen upper extremity joint
Apremilast reduced progression in all-comers but most impactful in those with +risk factors
@RheumNow #ACR26 Abst2307 https://t.co/chXL2z7ZQK
Brian Jaros, MD @Dr_Brian_MD ( View Tweet )
32 minutes 21 seconds ago
In 8,090 RApts 18.3% had unacceptable pain and 14.6% had patient-physician discordance ≥3 cm. #ACR26 Abstract 0617: discordance was the strongest correlate of unacceptable pain, followed by joint distribution and disability. Ask why pain and inflammation disagree. @RheumNow https://t.co/8zVt1fo30J
Bella Mehta @bella_mehta ( View Tweet )
32 minutes 24 seconds ago
Ixekizumab + tirzepatide vs. Ixekizumab alone in PsA
TOGETHER-PsA Trial
Primary outcome: ACR50 + 10% weight loss...
So Ixe alone barely met this - setup for failure w/ this outcome
Raw ACR20/50/70 more interesting - combo did better
@RheumNow #ACR26 Abst2297 https://t.co/fBOcq4UIjy
Brian Jaros, MD @Dr_Brian_MD ( View Tweet )
32 minutes 28 seconds ago
Can genetics sharpen the search for silent RA-ILD?
#ACR26: In 186 RA patients, 21% had subclinical ILD on HRCT.
Clinical screening achieved an AUC of 0.713; adding MUC5B improved it only modestly to 0.739.
Genetics adds risk, but limited discrimination.
@RheumNow #ACR26 https://t.co/WjK8TFP45m
Licia Mota @Mota_licia_reum ( View Tweet )
32 minutes 32 seconds ago
Secukinumab works regardless of erosive burden in PsA
Post-Hoc analysis of FUTURE-5:
ACR20 when stratified by baseline erosion score nearly identical in TNF-naive pt
ACR20 in TNF-exposed pt numerically higher in those w/ greater erosive burden
@rheumnow #ACR26 Abst2285
Brian Jaros, MD @Dr_Brian_MD ( View Tweet )
32 minutes 40 seconds ago
Can adverse pregnancy outcomes predict SLE or RA?
Abstract 2860 found:
- Future SLE assoc. w/ hx of preeclampsia (aOR 1.89), emergency c-section (aOR 1.90), and short gestational duration (aOR 0.93)
- Future RA assoc w high pre-pregnancy BMI (aOR 1.19)
@RheumNow #ACR26
Akhil Sood MD, MS @AkhilSoodMD ( View Tweet )
32 minutes 42 seconds ago
Which patient with ICI joint disease will have persistent disease?
Risk factors include:
- tenosynovitis on US/MRI
- elevated CRP
- baseline GC use
- age <65
- peripheral inflam arthritis pattern
@RheumNow #ACR26 Abst2806
Brian Jaros, MD @Dr_Brian_MD ( View Tweet )
32 minutes 48 seconds ago