Tweets
RheumNow’s expanded coverage of the #ACR26 Annual Meeting is sponsored by UCB
All coverage content is independently selected by RheumNow and its faculty
Dr. John Cush @RheumNow ( View Tweet )
28 minutes 11 seconds ago
RheumNow’s expanded coverage of the #ACR26 annual meeting is sponsored by Eli Lilly and Company.
All coverage content is selected by RheumNow and its faculty.
Dr. John Cush @RheumNow ( View Tweet )
58 minutes 32 seconds ago
Are clinical scenarios into AI chatbots useful?
(both specialized eg OpenEvidence or generalist eg ChatGPT):
performance will vary (platform but also model, effort)
prompt structure critical
users (patients & clinicians) need to know real limitations
ABST0869 #ACR26 @RheumNow https://t.co/vPNvJlSXZY
Links:
David Liew @drdavidliew ( View Tweet )
1 hour 14 minutes ago
Who will progress in
#SSc-ILD?
+Scl70
Male
African American
#smoker
Worsening #mRSS
#aspiration
CRP, KL6?
60 SSc-ILD v 19 SSc no ILD
FVC%pred related to baseline
#KL6 & #ICAM-1
But NOT predicted worsening
But small study
Better markers needed
#ACR26 0037 @RheumNow @ACRheum https://t.co/mvpL17Mdjr
Janet Pope @Janetbirdope ( View Tweet )
1 hour 38 minutes ago
Impt pathway for #fibrosis & #inflammation?
FIbrosis in #sarcoidosis mediated thru
#TL1A
Myeloid cells —granulomas
TL1A effects
TNF
IL1beta
IL6
IL17
Drugs could be effective
Some already in #IBD
Ex
#Tulisokibart
#Duvakitug
#Afimkibart
🤷
#O019 #ACR26 @RheumNow @ACRheum https://t.co/GPKwEqWFkh
Janet Pope @Janetbirdope ( View Tweet )
1 hour 38 minutes ago
Short #telomeres are associated w #IPF
Cool study from #UCSF @ACRheum #ACR26 showed
#senescence
In #PPF & #SARD-ILD
-epithelial remodeling w #DNA damage
Same theme leading to ILD—#fibrosis
?Rx pathway for repair
#0025 @RheumNow https://t.co/8wjtYgBXNF
Janet Pope @Janetbirdope ( View Tweet )
1 hour 38 minutes ago
RheumNow’s expanded coverage of the #ACR26 annual meeting is sponsored by UCB.
All coverage content is independently selected by RheumNow and its faculty.
Dr. John Cush @RheumNow ( View Tweet )
1 hour 39 minutes ago
I used to think #SSc #scleroderma pts w #SjD #Sjogren’s did better as more
Mild ‘#CREST’
Nope 👎
#CSRG study N>1000 pts
showed #SjD had
=#mRSS
But
⬆️#GI #gut issues
⬆️ #ILD ? From +#Ro
⬇️worse #QoL
#0231 #ACR26 @ACRheum @RheumNow https://t.co/A4zxpc24XN
Janet Pope @Janetbirdope ( View Tweet )
2 hours 40 minutes ago
Rx of calcinosis in #SSc is ‘hard’
Small RCT of BID topical #sodium #metabiosulfite v #PBO
neg #trial but a trend to some imaging improvement at 4 mo
Tough trial to do
?need:
Larger, longer study
Higher dose?
Try sodium #thiosulfate instead
#0226
#ACR26 @ACRheum @RheumNow https://t.co/CyA1k4rnNr
Janet Pope @Janetbirdope ( View Tweet )
2 hours 40 minutes ago
#dcSSc active
Early allogenic #CAR-T -initial dosing had #mRSS drop of 16pts (L Chung)
Well tolerated
in vivo #CAR-T #CD19 N=3 SSc + for #skin & #lung 🫁 from China
+ in SLE NEJM just published
closer to scalable Rx vs autologous!
#ACR26 @RheumNow @ACRheum
#0223, 0225
Janet Pope @Janetbirdope ( View Tweet )
2 hours 40 minutes ago
Use deep B cell depletion in #diffuse #scleroderma if #rituximab fails?
🤞
Small case series from France showed #obinutuzimab seemed to be well tolerated and reduced #skin #score #mRSS post #RTX which was d/c for loss of effect or infusion rx’n
Need RCT
@RheumNow #0222 #ACR26 https://t.co/iEv2T4XcYS
Janet Pope @Janetbirdope ( View Tweet )
2 hours 40 minutes ago
There's a LOT of talk about CAR-T safety in autoimmune disease, and whether it's worth the payoff.
In amongst all the moving parts, it's not so simple.
here's my breakdown of what zola-cel has taught us so far @RheumNow #ACR26
https://t.co/mGZmOsoE8o
David Liew @drdavidliew ( View Tweet )
3 hours 51 minutes ago
Ultra-processed food & RA: In 108,886 participants, highest vs lowest intake was associated with incident RA (HR 2.58), but the association lost significance after nutrient adjustment. Findings support a potential role of dietary quality in RA development @Rheumnow #0949 #ACR26
Mrinalini Dey @DrMiniDey ( View Tweet )
3 hours 51 minutes ago
In 64 RA patients randomized to ITIS or Mediterranean diets, both groups improved over 3 months, with distinct microbiome/metabolomic response patterns. Different dietary interventions achieve clinical benefit through complementary biological mechanisms. #0948 @Rheumnow #ACR26 https://t.co/Ls1awH3pgE
Mrinalini Dey @DrMiniDey ( View Tweet )
3 hours 51 minutes ago
Low-dose naltrexone fails again :(
LoDoNaVasc blinded crossover RCT of 60 pts with remission/very low vasculitis activity. No difference in PROMIS physical or mental health
Supports results from @TheLancetRheum in fibromyalgia
Sadly, this does not seem to work
@RheumNow https://t.co/S2XRSyGvIZ
Mike Putman @EBRheum ( View Tweet )
3 hours 51 minutes ago