Colchicine & Statins: A significant interaction? Colchicine is frequently used in rheumatologic practice. Current ACR guidelines for gout management support anti-inflammatory prophylaxis, including colchicine, during initiation and uptitration of urate-lowering therapy https://t.co/eyDbfpQajN

Surgery for 1st MTP Osteoarthritis Hallux rigidus, or osteoarthritis of the first metatarsophalangeal joint (MTPJ), is common, but treatment options and long-term outcomes remain poorly understood. A 12-month clinical trial showed that first MTPJ arthrodesis (compared to https://t.co/fHda4GK4vA

Single center study of Probiotics in #PsA showed no benefit. 66 moderately active PsA pts (PASDAS>3.2) on stable Tx: Rx probiotic vs PBO x 12 wks. 56 pts analyzed, PASDAS <3 responders: 43% probiotic vs 65% PBO (P 0.167), w/ no change in gut permeability markers or stool https://t.co/g6icpjuQOU

UK survey study of 6607 autoimmune dz pts (91% female) saw females had longer Dx delays, more HCP visits, & signif more often told their Dz attributed to psychiatric (43% vs 33%: OR 1.56) or psychosomatic causes (34% vs 21%; OR 1.87). Females had slightly more misdiagnoses (48% https://t.co/tGhiWCSPy9

Study of Prognostic Nutritional Index (PNI) in 984 RA pts shows PNI is independently inversely corelated w/ RA dz activity, esp. PNI <45. PNI = ser albumin & lymphocyte count calculation (10 × s albumin [g/dL]) + (0.005 × lymphocyte count/mm³]). Other studies have shown modest https://t.co/AV3AGXwSfg

French National Health System study of 214,892 #RA pts (~40K on TNFi) found 562 demyelinating events (2008-2023) w/ cumulative 10 yr incidence of 0.32% w/ csDMARDs & 0.50% w/ TNFi (HR 1.47;1.11-1.95). Demyelinating events are rare in RA, but signif higher w/ TNFi https://t.co/6vUy5nsQ27

Washington Univ Medical School has recv $17 million from Advanced Research Projects Agency for Health to develop an intraarticular therapy using nanoparticles designed to regenerate osteoarthritis damage without any surgical intervention. https://t.co/hl5i3welwS https://t.co/M7LwbIYI88

92 early (<2 yrs) systemic sclerosis pts were treated with #MTX; 79% diffuse SSc. At 3 mos, 34% of dcSSc ≥25% reduction in mRSS - increasing to 612% a@ 24 mos (29% at 24 mos ITT w/ non-responder imputation). GC did not improve skin. Dz progression seen w/ 75% of MTX monoTx D/C https://t.co/WvqyI8GKjT

Prescribing New GLP-1-Based Therapies https://t.co/naNfd7B1zA https://t.co/WIi9ZIMH2l

How well do you know the week's news in rheumatology? RheumIQ Emails are becoming opt-in only Get the quiz by email Log in to receive each new case-based quiz directly in your inbox. https://t.co/i04scCX31o https://t.co/vV88xXfQ6W

Are Concerns Over Avacopan Efficacy Overblown? Avacopan (Tavneos), the complement pathway inhibitor for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), appeared strongly effective in an Italian registry study, maybe a step toward putting questions about https://t.co/4w2INKPFeT

EADV abstract showed daxdilimab (anti-ILT7; on plasmacytoid dendritic cells) was effective in mod-severe discoid lupus. Ph II RCT 72 refract. DLE RCT; DAX vs PBO - ↓ CLASI-A vs placebo @24 wks. wk 4 ≥50% CLASI-A ~62% vs 24% https://t.co/gJ4drxErGD https://t.co/TexG55dDBL

Symptomatic hand OA (HOA) increased signif in past decade in the Netherlands (esp women & older adults). PCP EHR study of 1.8 million Dutch patients ≥30 yrs. Betw 2013 & 2023, prevalence incr 65% (5.7 to 9.4%); incidence rose 20% (7.1 to 8.5/1000PY) https://t.co/HyqdwJ70y4 https://t.co/CU0NGccI3k

Singapore center study of 119 IIM pts (DM 57%; ASyS 23%, OM 15%), IMNM 4%). MDA5 Abs seen in 35% DM. Vs ASyS, MDA5-DM had signif more Skin Sxs (ulcers, papules, Gottrons, heliotrope, periungual erythema). MSK Sxs equal & higher CK levels in ASyS MDA5. 79% DM-ILD were MDA5+ https://t.co/hWaaeLUYkz