JAMA Internal Medicine reports that the number of hydroxychloroquine prescriptions increased from 367,346 to 683,999 (86.2%) from February to March 2020, and chloroquine prescriptions increased 158.6%, rising from 2,346 to 6,066 prescriptions. https://t.co/3MKsu5mOpx

Rheumatology reports a UK study of Clinical Practice Research Datalink and 17 760 incident RA pts; 42% who recv steroids; The HTN rate was 64.1 per 1000 PY & GC use assoc w/ 17% increased risk HTN (hazard ratio 1.17), esp at doses > 7.5 mg/d https://t.co/31Q2xiwvMp

Canadian 1484 incident early #RA pts (enrolled 2007–2017). SC MTX monotherapy had fewer Rx changes(45% SC vs 79% PO)with longer treatment duration. Similarly taking biologics or triple therapy had a longer time without treatment change. https://t.co/babj1MvTNB

FDA has approved guselkumab (Tremfya) for active psoriatic arthritis, making it the 1st IL-23 inhibitor approved for PsA. Approval is based on DISCOVER-1 & DISCOVER-2 RCTs. Dosing: 100 mg SC q8 wks after loading dose at 0, 4 wks. https://t.co/1nCWuC1zii

EMR analysis of 453 gout pts D/C from ED or hospital , shows that 28.3% received opioids at discharge (~80% new pts). Average dose 38mg morphine equivalent for a median duration of 8 days - more common with polyarticular gout, DM, prior opioid use https://t.co/wKRT6ExuSD

Nice overview of Lupus Nephritis (III, IV, V) and biopsy results from the Renal Fellow Network https://t.co/tw1d5ldM04

Who you gonna call? Fauci that's who. Listen to Fauci LTF! LTF!

FDA has approved a 6th adalimumab biosimilar - called Hulio (adalimumab-fkjp) with indications of rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, adult Crohn’s disease, ulcerative colitis, psoriasis. https://t.co/zMNsDjVewU

SLE study from UK Clinical Practice registry matched 4343 SLE pts 1:6 controls; found lupus had 80% increased mortality risk (HR 1.8; CV, infx, Resp, accident/suicide). Higher risk w. younger onset & steroid. HCQ significantly lowered mortality risk (45%) https://t.co/c3IfiSydRr

Reminders on Masking: 1. Everyone should wear masks; most who are infected dont know they are infx (asymptomatic); 2. Risk of transmission is directly correlated with the duration and intensity of contact - especially in closed quarters; less so if outside https://t.co/9nw43kPrhN