RheumNow Podcast – Lupus Delights (9.18.20)

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Dr Jack Cush reviews the news and journal reports from the past week on RheumNow.com:

COVID-19 Risks in Pregnant Women

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There has been little science or evidence regarding the effects of COVID-19 infection on pregnancy and vice versa; and now the recent MMWR addresses the subject with two new reports

Methotrexate-Pegloticase Combination in Refractory Gout - MIRROR Study

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The MIRROR study, an open-label pilot trial in refractory, uncontrolled gout patients, showed that pegloticase given in combination with methotrexate was safe and effective and maintained responses for 6 months after initiation. 

Belimumab Effective in Lupus Nephritis

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Dr. Rich Furie has lead a group of investIgators in reporting the significant efficacy of intravenous belimumab when added to standard of care induction therapy in patients with active lupus nephritis. This phase 3, 2-year study included 448 systemic lupus erythematosus patients with biopsy proven lupus nephritis (class III or IV +/- V) patients who required induction therapy and have a UPCR ≥1 g/g. 

Has the Risk of Hip Fracture Changed over Time?

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Data from the Framingham Heart Study has shown that hip fracture incidence has decreased over time, probably resulting from improved lifestyle changes (less smoking and heavy drinking). 

NSAIDs Shows No Advantage over CBT in Knee Osteoarthritis

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JAMA Internal Medicine reports on a controlled clinical trial of knee osteoarthritis patients wherein meloxicam responses were not significantly or clinically superior to placebo or CBT (after placebo).

Capsaicin Injection Improves Knee OA Pain

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Highly purified synthetic trans-capsaicin (CNTX‐4975) injected directly into the joint reduced pain in chronic knee osteoarthritis (OA), data from the open-label phase III VICTORY-3 trial showed.

Mediterranean Diet May Reduce Risk of RA

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Arthritis and Rheumatology reports that a Mediterranean diet (MD) is capable of reducing the high risk of RA among women who have smoked tobacco. The results stem from the E3N Study, a French prospective cohort study that collects dietary data on 98,995 women since 1990. An MD score was derived from standardized questionnaires.

Updated List of Drugs Inducing Lupus

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Drugs inducing lupus may account for nearly 30% of all subacute cutaneous lupus erythematosus (CLE) and up to 15% of systemic lupus erythematosus (SLE) cases. Moreover there are over 100 drugs capable of inducing drug-induced lupus erythematosus.

Comorbidities Impact Disease Activity in Spondyloarthritis

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An analysis of a large population-based cohort of axial spondyloarthritis (axSpA) patients shows that comorbidities are common and are associated with higher disease activity and higher levels of functional impairment.

RheumNow Podcast - ACR Reproductive Health Slides (9-11-20)

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Dr. Jack Cush reviews the 2020 ACR Reproductive Health Guidelines presented all week here on RheumNow. 

ACR 2020 Reproductive Guidelines - Lactation Guidance

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In this third excerpt from the ACR guidelines on managing reproductive health issues in rheumatic disease patients, we present recommendations regarding the use of glucocorticoids and guidance on lactation and medication use post-partum.