Brenda McShan: The Creative Heart of RheumNow

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A pivotal member of the RheumNow family, Brenda McShan, will be retiring with honors.

Generic Tofacitinib (6.26.2026)

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Dr. Jack Cush reviews the news and journal articles from RheumNow.com. Updates on tofacitinib, CAR-T therapy and AI.

EULAR26: Updates in SLE and APS

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Severe refractory systemic lupus erythematosus (srSLE) is a clinical state conceptualised as persistent high disease activity despite standard care with glucocorticoids and immunosuppressants.

Self-Directed Cognitive Behavioral Therapy for Chronic Pain

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2026 Guidelines for the Treatment of Axial Spondyloarthritis

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New and updated clinical guidelines released today provide comprehensive, evidence-based recommendations for the management of axial spondyloarthritis (axSpA) for both adults and children.

EULAR26: Pitfalls in Treat-to-Target

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Real-world or observational data from registries, claims datasets, or electronic health records can enable us to perform large-scale analyses.

2-Gene Blood Test for Kawasaki Disease in Febrile Children

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JAMA Network Open has publshed that a simple 2-gene blood test may aid the earlier diagnosis of Kawasaki disease in children with febrile illnesses. 

B cell Targeting in SLE

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Prospects are growing that an approved, off-the-shelf drug can rescue patients with certain ultra-refractory autoimmune diseases, a pair of new reports suggest.

No Fetal Risks with First Trimester NSAID Use

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PLoS Medicine has published a population-based retrospective cohort study from the Southern Israeli Pregnancy Registry (siPREG) project showing that 1st trimester exposure to NSAIDs was not associated with major congenital malformatoin (MCM) risk. 

Where are we with Biomarkers in Rheumatoid Arthritis?

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Biomarker interest has grown considerably in the last 2 decades, owing to advances in genetics, imaging, protein, and multiomics. Despite these advances, biomarkers as the predictive holy grail of RA therapeutics and prognostication have not yet advanced beyond rheumatoid serologies and C-reactive protein (CRP).

Redefining axial spondyloarthritis

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An editorial in Lancet Rheumatology calls for "..reframing axSpA as a systemic, autoimmune inflammatory disease with multiorgan involvement and substantial unmet need."

JAMA Review on Low Back Pain

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A comprehensive JAMA review synthesizes current evidence on the epidemiology, pathophysiology, clinical evaluation, and treatment of nonspecific low back pain, drawing on 108 publications identified from a PubMed search (2005–2026) and the most recent guidelines from the WHO, ACP, and NICE. While the primary audience is generalists, the review carries important implications for rheumatologists who regularly encounter patients with back pain in the context of inflammatory arthritis, axial spondyloarthritis, and other systemic diseases.