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Happy Diwali (11.1.2024)

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com.

Iberdomide Efficacy in Cutaneous Lupus

Iberdomide, a cereblon modulator that promotes degradation of transcription factors Ikaros and Aiolos, has been shown in a phase 2 trial to improve outcomes in subacute and chronic cutaneous lupus erythematosus (CLE).

Should They Put Off Hip Replacement Surgery?

The NEJM reports what should be obvious to rheumatologists: that older adults with severe hip osteoarthritis should opt for total hip replacement (THR) over conservative exercise measures as THR yields a clinically important improvement in pain and function.

GLP-1 Inhibitor Reduces Knee Osteoarthritis Pain

MedPage Today

Semaglutide (Wegovy) reduced pain and improved physical function in patients with obesity and knee osteoarthritis, a randomized trial showed.

Medscape 2024 Medical Student Experience Survey

Medscape has published a survey overview of US Medical Student impressions and experiences, satisfaction, what they think of their education and how prepared are they for the USMLE (boards) and residency.

SGLT2 Inhibitor Protective Effects in Lupus

Systemic lupus erythematosus (SLE) outcomes were assessed based on whether they received sodium-glucose co-transporter 2 inhibitors (SGLT2i), in the setting of comorbid type 2 diabetes (T2D).

Filgotinib Efficacy and Safety - 3 Years Later

MedPage Today

Filgotinib, the rheumatoid arthritis (RA) oral drug that never made it to the U.S. market but is sold across Europe, Great Britain, and Japan, remained effective for 3 years for most registration trial participants who continued in a long-term extension study, researchers said.

Swapping is Better than Cycling in Psoriatic Arthritis

A real-world cohort study suggests that psoriatic arthritis failing to respond to TNF inhibitors (TNFi) may do better if they subsequently swap to an IL-17 inhibitor, rather than cycling to another TNFi.

Treatment Options for Dupuytren’s Contracture

The NEJM reports that in a randomized, controlled, head to head trial, collagenase injections were non-inferior to limited fasciectomy in the treatment of Dupuytren’s contracture.

Blue Collar Arthritis (10.25.2024)

Dr. Jack Cush reviews the news and journal articles from this past week on RheumNow.com.

Trends in DMARD Use in Juvenile Arthritis 2001-2022

Arthritis & Rheumatology reports that treatment trends in juvenile idiopathic arthritis (JIA) in the last two decades finds rising use of newer biologic and targeted synthetic DMARDs coupled with a decline in conventional DMARD use.

Potential OA Treatment - Chemokine CCL17 Inhibition

MedPage Today

Patients with osteoarthritis (OA) of the knee receiving an investigational chemokine inhibitor showed some improvements in pain and disability, said researchers with the drug's developer.