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CDAI remission does not describe every symptom. In a 787-patient RA study, those in remission still had meaningful pain interference (19%), fatigue (20%) and impaired function (23%). PROMIS scores show symptoms that composite score missed. #2874 @Rheumnow #ACR26

In 8,090 RApts 18.3% had unacceptable pain and 14.6% had patient-physician discordance ≥3 cm. #ACR26 Abstract 0617: discordance was the strongest correlate of unacceptable pain, followed by joint distribution and disability. Ask why pain and inflammation disagree. @RheumNow https://t.co/8zVt1fo30J

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Can genetics sharpen the search for silent RA-ILD? #ACR26: In 186 RA patients, 21% had subclinical ILD on HRCT. Clinical screening achieved an AUC of 0.713; adding MUC5B improved it only modestly to 0.739. Genetics adds risk, but limited discrimination. @RheumNow #ACR26 https://t.co/WjK8TFP45m

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Can adverse pregnancy outcomes predict SLE or RA? Abstract 2860 found: - Future SLE assoc. w/ hx of preeclampsia (aOR 1.89), emergency c-section (aOR 1.90), and short gestational duration (aOR 0.93) - Future RA assoc w high pre-pregnancy BMI (aOR 1.19) @RheumNow #ACR26

Which patient with ICI joint disease will have persistent disease? Risk factors include: - tenosynovitis on US/MRI - elevated CRP - baseline GC use - age <65 - peripheral inflam arthritis pattern @RheumNow #ACR26 Abst2806

RA Treatment: A New Nerve Pathway #ACR26 Abstract 1426 | RESET-RA: 242 patients with prior b/tsDMARD failure. At 24 months, vagus nerve stimulation achieved ACR20/50/70 rates of 70.9%/43.6%/25.5%, with ~55% reaching LDA/remission, without add-on therapy. @RheumNow https://t.co/ko6jvXcoRc

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Is air pollution linked to higher arthritis activity? Abstract 2859 found: - PM10, PM2.5 & NO2 each tracked with higher CDAI & DAPSA - every 1-quartile incr. in all together associated with higher: • DAS28 (RA/SpA) +0.06 • CDAI (RA) +1.46 • DAPSA (PsA) +1.60 #ACR26 @RheumNow https://t.co/iIHfCMbn3P

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2 Weeks off Methotrexate Boosts Zoster Response Consider holding methotrexate for two weeks after each recombinant zoster vaccine dose when disease is stable, and give the vaccine before rituximab when timing allows. Those are the messages from a pair of abstracts presented by https://t.co/qeEQp0LeHB

Jamshaid & Gomaa (Tirzepatide vs semaglutide cohort): Tirzepatide vs semaglutide in inflammatory arthritis: steroid use at 1 year was 19.1% vs 22.5% in matched cohorts. @rheumnow #ACR2026 Abstract#2641

Weber et al. (TOGETHER PsO&PsA): 30% lower predicted 10-year CVD risk vs pts IXE mono. suggest that targeting both inflammatory and metabolic pathways may improve CV benefit and potentially reduce long-term CV burden in this high-risk population. @rheumnow #ACR2026 Abstract#2299

Weber et al. (TOGETHER cardiometabolic analysis): ixekizumab + tirzepatide was associated with about 30% lower predicted 10-year CV risk vs ixekizumab alone at week 36. @rheumnow #ACR2026 Abstract#2299 https://t.co/NmulNKUwLL

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Jamshaid et al: Tirzepatide vs semaglutide in inflammatory arthritis: 3-year steroid use was 27.2% vs 37.5%. Less treatment escalation is intriguing. @rheumnow #ACR2026 #ACRBest Abstract#2641

Which patients with started on GC are at increased risk of metabolic AEs? Abstract 2754 found that baseline - CHF (OR 3.21) > CKD (OR 1.86) strongest predictors - MTX use lowered risk (OR 0.68) @RheumNow #ACR26 https://t.co/ZLWCcypf4W

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Inflammation may improve while pain persists in SLE. #ACR26 Abstract 2824: in 372 pts, 37% had mixed inflammatory + nociplastic symptoms. Over follow-up, inflammation declined but polysymptomatic distress stayed flat; ~37% remained above the nociplastic threshold. @RheumNow

Access matters. Among 16381 Canadian adults with RMDs and diabetes starting metformin, semaglutide initiation was lower in the poorest vs high-income neighbourhoods (aHR 0.86), despite a higher obesity burden. #2705 @Rheumnow #ACR26 https://t.co/uAzwdowufE

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In an updated systematic review and meta analysis for the GRAPPA treatment guidelines, men with PsA had higher odds of response than women across advanced therapies: ACR20 1.42, ACR50 1.74 and minimal disease activity 1.94. Placebo response did not differ by sex, odds ratio 1.00.

Pain is not always inflammation in RA. Among 283 pts starting/changing DMARDs, 4 phenotypes emerged. One had the highest pain, fatigue, poor sleep and distress despite only moderate inflammation and remained most symptomatic at 12 weeks. #ACR26 @RheumNow https://t.co/stcP70a4iZ

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A new RA target? Modified scores excluding TJC & patient global identified more patients with low inflammatory activity, with similar/lower radiographic progression than conventional remission. Useful where comorbidities may influence assessments #2808 #ACR26 @Rheumnow #ACRBest https://t.co/GZUOBc3mKn

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RISE: Inflix -> Inflix Biosim Ab#2807 #ACR26 @RheumNow CDAI (n=~1500), RAPID3 (n=~3100) analysis Biosimilar infliximab equally effective in switched pts https://t.co/Ud6sZeJFhU

RA-ILD: The Warning Signs Are Already on CT 30% of patients with RA-ILD progressed within 2 years. Definite UIP and inspiratory mosaic attenuation independently predicted progression, reaching 70% when both were present. @RheumNow #ACR26 https://t.co/9MiPIOJFil

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