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Anti-Rheumatic Rx

Dr. John Cush
@RheumNow
Does IVIG have a Role in Scleroderma? A recent systemic review and meta-analysis by Jozelio Freire de Carvalho and colleagues analyzed the available literature on this therapy. This study, published in Frontiers in Immunology in October 2026, evaluated the available evidence https://t.co/a8J2UT2I7Y

FDA Approves Tildrakizumab for Psoriatic Arthritis

Jack Cush, MD

Sun Pharmaceuticals announced Friday that the FDA has approved its IL-23 inhibitor, tildrakizumab  (Ilumya) for use in patients with active psoriatic arthritis. This agent is already FDA approved for plaque psoriasis, and joins guselkumab and risankizumab as the third IL-23 inhibitor

Dr. John Cush
@RheumNow
Tocilizumab is effective in glucocorticoid-resistant adult-onset Still’s dz. 40 AOSD pts rx w/ TCZ (4-8 mg/kg q4wks). @12 mos clin remission 55%, 6 mos CID 62%, signif drops in CRP, ESR, ferritin & daily pred decr 91% (50 to 4.4 mg; p<0.001). TCZ retention 65%; MAS 7.5% & https://t.co/jtAxrz6ETd
sheila
@RHEUMarampa
Prof. AHoi presented their study on ESR as potential source of risk info in SLE 48% discordance bet ESR & conv. serology Isolated ⬆️ESR levels showed ⬆️ assoc with dse activity and flare; risk increases further if combi ⬆️ESR+low c3/4+antidsDNA @RheumNow #APLAR2026 https://t.co/BvC0OZFjd5
sheila
@RHEUMarampa
Optimizing GC use in SLE: In arthritis, avoid oral GC - consider NSAIDS, csDMARDs, small molecules or biologics On GC initiation, hit hard w/pulse MP then taper early and rapidly In LN, treat aggressively bec damage is driven by dse activity, not meds @RheumNow #APLAR2026 https://t.co/Q5gFpr8P9k
Dr. John Cush
@RheumNow
The Efficacy of Ianalumab in Sjögren’s Disease The NEPTUNUS-1 and NEPTUNUS-2 trials have showed that monthly ianalumab is superior of placebo at improving Sjögren’s disease activity at week 48, even though there was no significant ESSDAI response or in the change in SSSD or https://t.co/YStzIFq5Bx
Dr. John Cush
@RheumNow
Tx persistence & response in PsA is a problem - influenced by demographics & Dz severity. 815 PsA pts in e Brit Society Rheumatology PsA Registe. @12 mos - 24% MDA, 24% ACR50. Median F/U 31 mos, only 65% still on index Rx. D/C higher w/ PDE4i & poorer baseline activity & PROs https://t.co/BhxAMtjsZV

Mixed Drinks, Mixed Results (10.30.2026)

Jack Cush, MD

Dr. Cush reviews the news and journal reports from this past week on RheumNow. This week on the podcast: hopeful guidelines for PMR; certainty about good & bad beverages in gout; mixed results in Sjogren's; non-lupus drugs saves lupus lives; and big hips sink ships in psoriatic arthritis

Beyond Chondrocalcinosis - What’s New in CPPD Disease

Jack Cush, MD

An overview of calcium pyrophosphate deposition (CPPD) disease by Sara Tedeschi presents our evolving understanding of CPPD with advances affecting nomenclature, classification, imaging, genetics, long-term outcomes and potential future targeted therapies. This review builds on other important

The Efficacy of Ianalumab in Sjögren’s Disease

Jack Cush, MD

The NEPTUNUS-1 and NEPTUNUS-2 trials have showed that monthly ianalumab is superior of placebo at improving Sjögren’s disease activity at week 48, even though there was no significant ESSDAI response or in the change in SSSD or ESSPRI symptom scores.

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