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Anti-Rheumatic Rx

Trends in DMARD Use in Juvenile Arthritis 2001-2022

Arthritis & Rheumatology reports that treatment trends in juvenile idiopathic arthritis (JIA) in the last two decades finds rising use of newer biologic and targeted synthetic DMARDs coupled with a decline in conventional DMARD use. Adalimumab is most used

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SPRINGBOARD: Extended-release Intra-articular Corticosteroid Injection in Knee OA A phase 2 trial of EP-104IAR (long-acting, fluticasone propionate) has shown 14 weeks of clinically meaningful pain relief in knee osteoarthritis (OA). This intra-articular formulation is… https://t.co/TSeqNVysjb https://t.co/0OVCobGqsp
Dr. John Cush @RheumNow( View Tweet )
2 yr results from the PRAIRI study - 78 at-risk (for RA) pts Rx w/ placebo or 1000 mg IV RTX + I00 mg methylprednisolone (MP). While 1 yr result showed brief delay in RA development, at 2 yrs there was no benefit for QOL or RA development https://t.co/1CzEQn5zL4 https://t.co/Wvr2kWvDC5
Dr. John Cush @RheumNow( View Tweet )

Potential OA Treatment - Chemokine CCL17 Inhibition

MedPage Today

Patients with osteoarthritis (OA) of the knee receiving an investigational chemokine inhibitor showed some improvements in pain and disability, said researchers with the drug's developer.

In a phase I study that also included placebo-controlled efficacy testing, Western Ontario and

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Long-term Tofacitinib in Juvenile Idiopathic Arthritis

The long-term safety and efficacy of tofacitinib in patients with juvenile idiopathic arthritis (JIA) has been established in an ongoing long term extension (LTE) study.

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#VEXAS can present as atypical &/or refractory #ANCA-associated #vasculitis Consider possibility of VEXAS in cases of AAV ▶️Refractory to multiple treatment ▶️Atypical kidney biopsy 👉🏽https://t.co/1Vewb5n5vZ via @RheumJnl https://t.co/FLov5xaQAA
Dr Ai Lyn Tan @DrAiLynTan( View Tweet )
Pain Relief in RA: JAK Better than TNF Inhibitors? Targeted drugs for rheumatoid arthritis (RA) are not created equal when it comes to pain relief, a retrospective study from Sweden indicated, although the differences appeared to be modest. https://t.co/XjJtfIu0Ku https://t.co/xOVernmgHE
Dr. John Cush @RheumNow( View Tweet )

SPRINGBOARD: Extended-release Intra-articular Corticosteroid Injection in Knee OA

A phase 2 trial of EP-104IAR (long-acting, fluticasone propionate) has shown 14 weeks of clinically meaningful pain relief in knee osteoarthritis (OA).
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Predictors of Adverse Pregnancy Outcomes in Lupus

A large metanalysis of systemic lupus erythematosus (SLE) patients and pregnancy outcomes suggests that adverse pregnancy outcomes are more likely in those with lupus nephritis, chronic hypertension, SLE disease activity before and at
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US health expenditures grew from $4.1 trillion in 2020 to $4.5 trillion in 2022 (17.3% incr). US saved >$400 billion in 2022 by using generic and biosimilar drugs, https://t.co/Z8kS4elyA3 https://t.co/3LopIiQiqZ
Dr. John Cush @RheumNow( View Tweet )

Anxiety and Depression Rising in Rheumatoid Arthritis

A Mayo Clinic study shows that over three decades, anxiety and depression have become more common in individuals with rheumatoid arthritis (RA).

Data drawn from the Rochester Epidemiology Project identified incident adult RA (age

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Pain Relief in RA: JAK Better than TNF Inhibitors?

MedPage Today

Targeted drugs for rheumatoid arthritis (RA) are not created equal when it comes to pain relief, a retrospective study from Sweden indicated, although the differences appeared to be modest.

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Impact of biosimilars on biologic drug development pipelines. https://t.co/7kc0UDVPTy https://t.co/bPV3wAc2XY
Dr. John Cush @RheumNow( View Tweet )
Metanalysis of 40 papers, 486,465 RA pts & 3,928 incident ILD outcomes shows no signif risk of ILD w/ DMARD use; no ILD risk w/ TOFA or TNFi (Oral Surveillance n=2,911; OR 0.94). MTX use yielded a Lower ILD risk (OR 0.49; 0.32 to 0.76) vs no MTX use. https://t.co/Es8yyEiD8r https://t.co/qOYPkWNi9o
Dr. John Cush @RheumNow( View Tweet )
Health Disparities in DMARD Use in RA A UK study shows biological and targeted synthetic DMARD (b/tsDMARDs) use in newly diagnosed rheumatoid arthritis (RA) varies markedly by ethnicity, age and setting - "one-size-fits-all approach" does not apply. https://t.co/t7O99FM7fQ https://t.co/CtvfblpPUo
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ANA+ consult (10.18.2024)

Dr. Jack Cush reviews the news and journal articles from this past week on RheumNow.com.

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Alendronate Atypical Fractures Back In Court

Reuters reports that a U.S. appeals court on Friday revived more than 500 lawsuits alleging that Merck failed to warn that patients taking alendronate for osteoporosis may be at increased the risk of atypical femoral fractures.

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Economic and Mental Health Burden of Rheumatoid Arthritis

EurekaAlert!

A University of Mississippi-led comprehensive study of a disorder that affects 4.27 million Americans nationwide is revealing just how significant its burdens are on patients' financial well-being and quality of life. Patients with rheumatoid arthritis pay an average of $3,383 more per year

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Health Disparities in DMARD Use in RA

A UK study shows biological and targeted synthetic DMARD use in newly diagnosed rheumatoid arthritis varies markedly by ethnicity, age and setting - "one-size-fits-all approach" does not apply.

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Inadequate Zoster Vaccination in Immunocompromised Patients

A VA study of shows that recombinant zoster vaccine (RZV) vaccination in immunocompromised patients or those receiving immunosuppressive medications is insufficient, given these are high risk individuals.

The recombinant zoster vaccine (RZV; or "Shingrix") was FDA approved In 2017 for

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Run-Walk Exercise May Help Lower Back Pain

MedPage Today

Adults younger than age 45 with chronic, nonspecific lower back pain saw significant pain relief with a structured run-walk program in a randomized trial.

At the end of 12 weeks, participants in the program scored their pain level an average 15.3 points lower (95% CI 5.3-25.3), on a 100

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Dot the "i", Cross the "t" (10.11.2024)

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com. Today’s reports suggest where to look for help, especially with regard to pain.

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World renowned faculty delivering state of the art lectures. Early bird registration for RheumNow Live is now open! https://t.co/Yk8dKDdZie https://t.co/d14Mq2AxlI
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Screening to Prevent Multimorbidity in Rheumatic Patients

A population based screening program of patients with chronic inflammatory rheumatic diseases (IRD) demonstrates that systematic screening IRD patients for multimorbidity increased preventive interventions and reduced hospital admissions. 

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Analgesic Prescribing in Patients with Inflammatory Arthritis A UK cross-sectional EHR clinical practice analysis between 2004 and 2020 shows that analgesic prescribing in inflammatory arthritis (IA) patients has declined, but still remains substantial, including opioid… https://t.co/K43YERU3rf https://t.co/DRZ4r9JDSv
Dr. John Cush @RheumNow( View Tweet )