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Lupus

The Window of Opportunity (5.24.2024)

Dr. Jack Cush reviews the journal reports and news from the past week on RheumNow.com. This week: blockbuster drugs, opioids in rheumatology and nontreatment of inflammatory arthritis?

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Lupus Research Alliance Grants for Lupus Innovation

EurekAlert!

The Lupus Research Alliance (LRA) is proud to announce that nine international researchers are the recipients of this year’s Lupus Innovation Award (LIA). They will conduct innovative research to uncover the underlying mechanisms and identify novel targets and pathways that could be harnessed

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No Link Between Autoimmune Diseases and Monoclonal Gammopathy of Undetermined Significance

Annals of Internal Medicine reports a study of more than 75,000 persons screened for monoclonal gammopathy of undetermined significance (MGUS) and found no association between autoimmune rheumatic disease (AIRD) and MGUS.

While MGUS may be a precursor to

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SLE Cost of Care and Disease Activity

A longitudinal, multinational study shows that SLE patients achieving remission or low disease activity incur lower overall direct/indirect (DCs, ICs) healthcare costs than those with persistent activity. 

The study included

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Upside/Downside of Steroids in Lupus Nephritis

A systematic review of randomized clinical trials of patients with biopsy-proven lupus nephritis (LN) demonstrates both the benefits and harms to early glucocorticoid (GC) regimens on lupus outcomes. 

This meta-analysis of the control arms of 50 RCTs

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Small-molecule Drugs to Treat Systemic Lupus Erythematosus A metanalysis of randomized controlled trials (RCTs) on treatments of systemic lupus erythematosus (SLE), confirm the efficacy of several targeted small-molecule drugs. https://t.co/O3Y3KBngau https://t.co/wiB1EMtMFK
Dr. John Cush @RheumNow( View Tweet )
Interferons and Lupus Subsets In a new study, researchers from Johns Hopkins Medicine say they have uncovered insights as to the relationship between interferons and lupus, which affects up to 1.5 million Americans. https://t.co/Eo8q3IGPb7 https://t.co/gVyHJwZFwc
Dr. John Cush @RheumNow( View Tweet )
Save the date! We’ll be covering #EULAR24! https://t.co/HGjP2SFyOp
Dr. John Cush @RheumNow( View Tweet )

Infectious Mortality in Autoimmune Rheumatic Disorders

Infectious conditions are a significant cause of mortality in autoimmune rheumatic diseases (ARD). Among patients hospitalized with an infection, we compared in-hospital and long-term (3-year) mortality between those with and without ARD.

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Small-molecule Drugs to Treat Systemic Lupus Erythematosus

A metanalysis of randomized controlled trials (RCTs) on treatments of systemic lupus erythematosus (SLE), confirm the efficacy of several targeted small-molecule drugs. 

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Interferons and Lupus Subsets

EurekAlert!

In a new study, researchers from Johns Hopkins Medicine say they have uncovered insights as to the relationship between interferons and lupus, which affects up to 1.5 million Americans

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10 Lupus Tips on May 10 (World Lupus Day) by @LupusMore https://t.co/mON5ZyTpUE #lupus #SLE #LupusAwarenessMonth

Donald Thomas, MD @lupuscyclopedia( View Tweet )

✅ Holistic #Lupus Management in 2024 👍 #LupusAwarenessMonth https://t.co/RY6AcHS9WQ
Laurent ARNAUD @Lupusreference( View Tweet )
Multiplicative Adverse Effects of Social Determinants of Health in Lupus Nephritis: A Meta-analysis and Systematic Review https://t.co/C6G3VePklU https://t.co/zVoLeI8ZxA
Dr. John Cush @RheumNow( View Tweet )
ICYMI: Tuesday Night Rheumatology- Mastering SLE This webinar will feature highlights from these lectures followed by live audience Q & A https://t.co/CLJbtvJKOT https://t.co/hGSK4P7NlF
Dr. John Cush @RheumNow( View Tweet )
CD19 is not expressed on Plasma Cells or Plasmacytoid dendritic cells. Yet, Selective CAR-T cell mediated B cell depletion suppresses interferon signature in SLE !! https://t.co/3DsonHZiWp https://t.co/dk5ZtQRnOm
Dr. John Cush @RheumNow( View Tweet )

Multiplicative Adverse Effects of Social Determinants of Health in Lupus Nephritis: A Meta-analysis and Systematic Review

A metanalysis shows that social determinants of health adversely impacts patients with lupus nephritis. Lupus nephritis is a significant complication of SLE, often with dramatic increases in morbid and mortal risks. Outcomes are likely to be augmented by social determinants of health, including

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FDA issued a drug safety warning linking thiopurine (AZA, 6MP) use in pregnancy & a rare risk of intrahepatic cholestasis of pregnancy (ICP). ICP has been reported in pts w/ CD, UC, or SLE; however thiopurines are not FDA approved for these Dx https://t.co/s37eRuAtQx

Dr. John Cush @RheumNow( View Tweet )

Very late onset Lupus (>60) is less female, less arthritis/dz activity, lower dsDNA, C3, SSA, SSB and ANA but more Sjogrens & RA? Single clinic study of 845 SLE - jSLE (<18), aSLE (18-49), lSLE (50-60), and vlSLE (>60).vlSLE had lowest survival (20yrs) https://t.co/VwDSArDhrc https://t.co/3pSr0xSCKn
Dr. John Cush @RheumNow( View Tweet )
“50% of pts with lupus nephritis are asymptomatic . You have to have a degree of kidney damage before you have proteinuria. Proteinuria does not correlate with intrarenal activity.” – Dr. A Fava #RNL2024 @rheumnow https://t.co/w6UktVozsj

Dr. John Cush @RheumNow( View Tweet )

Full-read Overview of Macrophage Activation Syndrome - a rare complication of autoimmune inflammatory rheumatic dz; assoc w/ Still’s disease SLE, Kawasaki, dermatomyositis, RA, Sjögren’s. Precipitating factors, including genetics & infections reviewed https://t.co/LmL3BPmo6c https://t.co/OkfwpzNLAL
Dr. John Cush @RheumNow( View Tweet )
"Clinical Pearl! Lupus flare mimics with Dr. Kahlenberg - FM - Stress - Infection - Lack of sleep - Iron deficiency - Vitamin D deficiency - Celiac or other concomitant inflammatory disease - thyroid issues @Kahlenberglab #RNL2024 https://t.co/byNpSPuzC0"

Dr. John Cush @RheumNow( View Tweet )

Biology and Rx of Lupus Flares https://t.co/VlaI1PK8X8 https://t.co/oFXqGUvL4b
Dr. John Cush @RheumNow( View Tweet )

Featured BSR Abstracts (5.2.2024)

Dr. Jack Cush muses on the news, journal reports, FDA announcements and the 2024 BSR abstracts just released.

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