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Lupus

AURORA-1: Voclosporin Efficacy in Lupus Nephritis

May 11, 2021

Lancet has published the results of the AURORA-1 trial, wherein the calcineurin inhibitor, voclosporin, was tested in a placebo controlled trial of lupus nephritis and shown to be effective at inducing a complete renal response.

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Higher Hydroxychloroquine Blood Levels Reduces Thrombosis Risk in Lupus

May 10, 2021

Petri and colleagues have published that measuring hydroxychloroquine (HCQ) blood levels can be useful in systemic lupus erythematosus (SLE), as low levels are associated with an increased thrombotic risk in SLE.



In total cohort of 739 SLE patients, HCQ levels were serially quantified

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RheumNow Podcast – Falling or Falling in Love?

May 06, 2021

Dr. Jack Cush reviews the best journal articles from the past week on RheumNow.com.

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Childhood Lupus May Hamper Adult Careers

May 04, 2021

Long-term outcomes of kids with childhood-onset systemic lupus erythematosus (cSLE) are uncommon, but this cSLE cohort analysis suggests that SLE significantly impacts their future education, vocation, and employment as they reach adulthood.



A cohort of 106 cSLE (93% female, 73% White

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Autoimmune Thyroid Disease in Women

May 04, 2021

JAMA has posted an insights article reviewing autoimmune thyroid disease in women. Thyroid autoimmunity has a higher prevalence in women and with increasing age.



Similar to many autoimmune disorders, thyroid disease is more common in women than in men.

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Higher Cardiovascular Risks with Systemic Lupus Erythematosus

May 03, 2021

The Journal of the American College of Cardiology has published the results of a study showing that patients with systemic lupus erythematosus (SLE) have an increased risk of heart failure (HF) and other long-term cardiovascular outcomes. 



Data taken from Danish

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Lupus Activity Affects Mortality

MedPage Today
Apr 23, 2021

Each one-unit increase on a disease activity score during the first year after enrollment into a systemic lupus erythematosus (SLE) cohort was associated with a significant increased risk for death and organ damage during subsequent follow-up, researchers reported.

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RheumNow Podcast – Coconspirators: RA and Lung Disease

Apr 23, 2021

Dr. Jack Cush reviews and discusses more than a dozen news and journal articles from the past week on RheumNow.com.

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RheumNow Podcast – Combination Biologics

Apr 16, 2021

Dr. Jack Cush serves up this week's news and articles from RheumNow.com.

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Autoimmune Risk of Death Up during COVID

Apr 15, 2021

A population-based study in the UK shows that patients with rare autoimmune rheumatic diseases (RAIRD) were 44% more likely to die during the 2020 COVID-19 pandemic (March - April) compared to either the general population or their pre-COVID risk.



This cohort study compared hospital

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DMARD Dropouts During COVID-19

Apr 12, 2021

A full year from the onset of the SARS-COV-2 pandemic, rheumatologists are still seeing the consequences of COVID, with many patients avoiding usual care, follow-up visits, routine lab testing and with many self-stopping their antirheumatic meds, because it seemed like the right thing to do

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Rheumatology Care Derailed by COVID-19

Apr 06, 2021

A survey study from the  ArthritisPower PPRN or CreakyJoints database shows that during the COVID-19 pandemic patient care was substantially affected in unforeseen ways.



Data from the ArthritisPower Patient-Powered Research Network and CreakyJoints patient community were gathered by

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Inflammatory Conditions Up the Risk of Premature Myocardial Infarction

Mar 31, 2021

The European Journal of Preventive Cardiology reports that younger patients with their first myocardial infarction before age 50 yrs have a higher risk of having a systemic inflammatory disease (SIDs) and higher rates all-cause mortality.



Data derived from the retrospective

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News Feature: Are You a Super Rheum? https://t.co/LsGpFNXlkp https://t.co/Q9iojEQNqL
Dr. John Cush @RheumNow( View Tweet )
Mar 19, 2021
BC Canada population study shows newly diagnosed #SLE patients (n=5,169) have a higher rate of 1st serious/sever infections (1.8-fold), and more total severe infections (2.1-fold) and infection-related mortality (1.6-fold) vs general population. https://t.co/acDk0WYSby

Dr. John Cush @RheumNow( View Tweet )

Mar 17, 2021

MDA-5 Antibodies and Juvenile Dermatomyositis

Mar 17, 2021

A multicentre, retrospective study examined MSA profiles (by immunoprecipitation) from 96 juvenile idiopathic inflammatory myopathies (JIIM) at nine pediatric rheumatology centres in Japan. MSA were found in 85 of 96 cases with over 90% of patients having one of the following three MSA types

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News Feature: Rheumatic Patients Are at Risk for COVID Death https://t.co/bhJG1vuVA4 https://t.co/VEN3nwSOPB
Dr. John Cush @RheumNow( View Tweet )
Mar 17, 2021

Rheumatic Patients Are at Risk for COVID Death

MedPage Today
Mar 16, 2021

Patients with rheumatic diseases who developed COVID-19 were at increased likelihood of death, with risk factors similar to those seen in the general population but also because of factors specific to their underlying disease and its treatment, analysis of data from an international registry

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Actemra FDA Approved for Systemic Sclerosis Interstitial Lung Disease

Mar 08, 2021

Genentech announced Thursday that the US Food and Drug Administration approved tocilizumab (Actemra) for the treatment of Systemic Sclerosis-associated Interstitial Lung Disease (SSc-ILD), specifically indicated for slowing the rate of decline in pulmonary function in adults SSc-ILD.

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News Feature: Higher Lupus Mortality Among Minority Populations https://t.co/l4xUz9se02 https://t.co/UsGRc2twWU
Dr. John Cush @RheumNow( View Tweet )
Feb 27, 2021
We are three weeks out from RheumNow Live. Are you planning on attending? https://t.co/vJlU0Z3Q3x

Dr. John Cush @RheumNow( View Tweet )

Feb 26, 2021

RheumNow Podcast – Sweet Lies or Hard Truths? (2.26.2021)

Feb 26, 2021

Dr. Jack Cush reviews and discusses the news and Journal reports from the past week on RheumNow.com.

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Single center, 40 yr experience shows lupus psychosis to be rare. Among 709 SLE pts, 18 (2.5%) developed lupus psychosis. 2/3 remitted w/ antipsychotics & immunosuppressives Psychosis more likely w/ RNP and less likely w/ cardiolipin Abs. https://t.co/XcRbxXz4zq

Dr. John Cush @RheumNow( View Tweet )

Feb 25, 2021

Higher Lupus Mortality Among Minority Populations

Feb 23, 2021

The February 19th MMWR reports that higher mortality rates in certain patients with systemic lupus erythematosus (SLE); data based on recent San Francisco County statistics showing a four fold higher mortality among Asian and Hispanic/Latina females with SLE.

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QD Clinics- The Sawtooth Steroid Taper Sawtooth Steroid Taper Surgery Rules for DMARDs & Biologics RA & DVT Traveling to Medical Meetings during COVID Hemoptysis and SLE When to do Genetic Testing in Febrile Patients https://t.co/dZLqGUyizG https://t.co/PYsH7K6ByB
Dr. John Cush @RheumNow( View Tweet )
Feb 23, 2021
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