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Lupus

2024 ACR Lupus Nephritis Guidelines: The Controversies Drs. Maria Dall’Era & Michelle Petri discuss the sticking points in the latest lupus nephritis recommendations. 🗣️ Insightful, honest, and essential for your practice. 📍Full update on RheumNow: https://t.co/KPjyCrMTBr https://t.co/VoOslSqs99
Dr. John Cush @RheumNow( View Tweet )

Belimumab in SLE with Mucocutaneous or Vasculitis Findings

A post hoc analysis of a belimumab (BEL) inn systemic lupus erythematosus (SLE) study showed lupus mucocutaneous and vasculitic  manifestations improve with BEL and standard care.
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Valves Gone Wild in SLE

Lupus valvulitis is a rare cardiac manifestation of active systemic lupus erythematosus (SLE) and is defined by inflammation of one or more cardiac valves. It is often associated with Libman-Sacks endocarditis, which is characterized by the presence of sterile vegetations on the heart

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Moving Targets in Lupus and Lupus Trials In the 1990s, developing lupus treatments became a priority, but success was elusive for 20 years. Belimumab was approved by showing only small differences from placebo in trials with 867 patients globally. Its efficacy was confirmed by https://t.co/TekxzTJjwC
Dr. John Cush @RheumNow( View Tweet )
Lupus Unlocked: Pregnancy and SLE https://t.co/Trkk49EEA4

Dr. John Cush @RheumNow( View Tweet )

Steroids in Lupus Nephritis: No Free Lunch https://t.co/yPQuZcnRLH https://t.co/V8GZoslSqV
Dr. John Cush @RheumNow( View Tweet )
NEW for #LUPUS2025—@ern_reconnet–SLICC–@SLEuroSociety expert consensus on the therapeutic management of rare systemic #lupus erythematosus manifestations https://t.co/XwAHpsho57 Free to read with registration on https://t.co/28wkm5ab69 (also free) @Lupusreference #SLE https://t.co/73K0DKTHye
The Lancet Rheumatology @TheLancetRheum( View Tweet )
🔺CTD-ILD radiological signs to look out for 👀 #CTD #ILD #UIP #NSIP #Fibrosis #scleroderma #systemicsclerosis #Sjogrens #Lupus By @IlliasulK https://t.co/hHupTz0bCy
Dr Gurdeep S Dulay @gurdeep_dulay( View Tweet )
Shifting the Management Paradigm for SLE and Lupus Nephritis The paradigm for treating patients with systemic lupus erythematosus (SLE) is rapidly shifting and our patients will surely benefit with improved outcomes. https://t.co/idxMBTyTwp https://t.co/unxmjVst3D
Dr. John Cush @RheumNow( View Tweet )
Single center study of 1538 #SLE pts found 2.2% w/ lupus mesenteric vasculitis (LMV) - 39 LMV episodes in 31 pts - 2/3 had Nausea, vomiting, diarrhea & abdominal pain (~15% peritoneal irritation) & had active Dz (renal, Skin, Heme). LMV responded to steroids & https://t.co/AkuvCl6nG6
Dr. John Cush @RheumNow( View Tweet )

50 Year Perspective on Lupus

An observational cohort study was started in Toronto by Dr. Murray Urowitz in 1970. The program was set up as a specialized clinic to provide care for patients with lupus, to study clinical laboratory correlations in the disease, and to better understand long-term outcomes of the disease. What

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Contemporary lupus nephritis treatment

Outcomes in lupus nephritis are akin to the glass half full. Serial monotherapy is out, as the percentage who achieved a complete renal response was very low and some went to end stage kidney disease (ESKD). Solutions?

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Diagnosing Neuropsychiatric SLE (5.23.2025) Dr. Jack Cush reviews the news and journal reports from RheumNow - including views on the vagus nerve, NPSLE and CAR-T mania. https://t.co/PadauvfWWA https://t.co/4k4nfHSPg5
Dr. John Cush @RheumNow( View Tweet )

2025 ACR Guideline for the Treatment of SLE

The ACR has released its 2025 Systemic Lupus Erythematosus (SLE) treatment guidelines and consensus-based good practice statements, applicable to children and adults with SLE. 

Overall, the goals of SLE management are to achieve remission or a low level disease activity, reduce

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How Living With Childhood-Onset Lupus Impacts Mental Health

Children, teens, and young adults living with childhood-onset systemic lupus erythematosus (cSLE) require intense immunosuppressive treatments to prevent serious organ damage. By the mid-2010’s, multiple studies were published that showed high rates of depression, anxiety, and suicidal

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IMPACT Study - Certolizumab Efficacy in APS Pregnancies

A pilot trial assessed the safety and value of tumour necrosis factor α inhibitor treatment with certolizumab in patients with high-risk pregnancies with antiphospholipid syndrome (APS
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Lupus Clinical Slides: Set 1 https://t.co/zFQqHfl8Ch https://t.co/kvVNAS17ec
Dr. John Cush @RheumNow( View Tweet )
SLE, Antiphospholipid Antibodies, and the Placenta It is well established that women with SLE are at increased risk for adverse pregnancy outcomes, including preeclampsia, preterm birth, and pregnancy loss. However, the pathophysiologic mechanisms driving these complications https://t.co/z0BOT3xsuQ
Dr. John Cush @RheumNow( View Tweet )
Does ADDING an #immunesuppressive To #belimumab in #SLE give more benefit? ❎ NO #RWE from Spain suggests no added improvement adding IS to Belimumab Should you switch Rx then? 🤷‍♀️ @RheumNow #LUPUS2025 poster110 #ClinicalPearl https://t.co/C3ydArMx7x
Janet Pope @Janetbirdope( View Tweet )
Treat to target 🎯 #SLE #recommendations Considerations are nuanced and Impt Lowest clinical disease activity is goal Try for remission 🎯 Get patients off #glucocorticoids If not ⬇️low dose #prednisone @RheumNow #LUPUS2025 https://t.co/HlBeh2FLxP
Janet Pope @Janetbirdope( View Tweet )
Lupus QD Clinic - Rhupus dsDNA+ SLE Plus CCP+ RA = Rhupus https://t.co/lyV7fgd1vp https://t.co/Ptw0dmyqCj
Dr. John Cush @RheumNow( View Tweet )
Lupus in an empty house The full house immunofluorescence pattern is the classic histopathologic finding of lupus and lupus nephritis. Glomerular deposits staining for IgG, IgA, IgM, C3 and C1q can help confirm a suspected diagnosis of systemic lupus erythematosus (SLE). This https://t.co/Zcywc5r9q9
Dr. John Cush @RheumNow( View Tweet )
Lupus Unlocked: Pregnancy & SLE 📅 May 27, 2025 6:00 PM CT | 7:00 PM ET | 4PM PT Join us for our final Lupus Unlocked webinar this month on pregnancy and SLE. In this webinar, panelists will discuss issues such as congenital heart block, lupus nephritis treatment, teratogenic https://t.co/gouTN7uzCo
Dr. John Cush @RheumNow( View Tweet )
Unmet needs in #lupus are many 👇 Timely #diagnosis Morbidity - CV, metabolic, OP, mental health Premature mortality - CAD, active #SLE, infection Issues w pregnancy #steroid side effects ⬇️QoL With partnerships we can ✅ Pts HCPs researchers Pharma Gov’t #LUPUS2025 @RheumNow https://t.co/9T9rIrM1hV
Janet Pope @Janetbirdope( View Tweet )
IL2 low dose in #SLE seems to + alter immune regulation Multiple targets to explore in #lupus Unravelling pathophysiology in SLE CD40L TLR7,8 #rapamycin type drugs CAR-T w novel CARS Etc #LUPUS2025 @RheumNow https://t.co/jeycgg4ZhT
Janet Pope @Janetbirdope( View Tweet )
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