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Rheumatoid Arthritis

RA BIOBADASER registry study of 1128 patients going on ts/bDMARD found 107 (9.3%) w/ multimorbidity (Charlson Comorbidity index ≥ 3). Multimorbid RA were older, more SJC & signif higher DAS28; ts/bDMARD retention rate equal groups https://t.co/am4Uoccla9 https://t.co/P7Ae2Jal2e
Dr. John Cush @RheumNow( View Tweet )
Feb 26, 2024
MMPs play pathogenic role in RA-ILD. Multicenter VA study of 2,312 RA pts, 96 had prevalent ILD & Incident ILD developed in 130 (IR 7.5/1,000PY). High MMP-7 increased ILD (adj OR 3.78) & incident ILD (adj HR 2.33). Higher MMP-9 did same https://t.co/3i49TsAQbt https://t.co/RA6Fu2jPeE
Dr. John Cush @RheumNow( View Tweet )
Feb 26, 2024
Eating for RA The majority of practicing rheums at RheumNow Live were unaware of the new ACR guidelines issued in 2022 regarding dietary and lifestyle recommendations for patients with RA. Dr. Monica Guma reviewed these guidelines during her lecture. https://t.co/9herN2musx https://t.co/P1xJn2lDrg
Dr. John Cush @RheumNow( View Tweet )
Feb 26, 2024
Top 5 Clinical Pearls in RA Management #RNL2024 provided a wealth of clinical insights, particularly in the realm of rheumatoid arthritis (RA) management. Here are the top five clinical pearls from the event's opening session, "Success in RA." https://t.co/DUalEZbfJB https://t.co/RZsW0SKc4J
Dr. John Cush @RheumNow( View Tweet )
Feb 24, 2024
The ARIAA trial tested the utility of IV abatacept in individuals ACPA+ arthralgia patients with subclinical inflammation and showed abatacept to decrease MRI inflammation, clinical symptoms, and risk of future RA development. https://t.co/PdYLKwT0z9 https://t.co/O8uHxzleIK
Dr. John Cush @RheumNow( View Tweet )
Feb 23, 2024

Immunosuppression Increasing (2.23.2024)

Feb 23, 2024

Dr. Jack Cush reviews the news and journal reports from the past 2 weeks on RheumNow.com; but begins with a discussion of what constitutes "immunosuppression" and how it applies to our patients.




  1. 2021 NHIS Survey data suggests the prevalence of immunosuppression in the USA is

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No clear link between weather and MSK symptoms

EurekAlert!
Feb 22, 2024

There is a longstanding belief that changes in weather conditions, such as impending rain or temperature, can trigger or worsen muscle and joint pain but Australian researchers have found no clear pattern between the two.



The research found that high temperatures and low humidity may

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Eating for Rheumatoid Arthritis

Feb 21, 2024

The majority of practicing rheumatologists at RheumNow Live were unaware of the new ACR guidelines issued in 2022 regarding dietary and lifestyle recommendations for patients with Rheumatoid Arthritis. Dr. Monica Guma reviewed these guidelines during her lecture on the impact of diet on disease

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ARIAA Trial: Abatacept Delays the Onset of RA

Feb 20, 2024

The ARIAA trial tested the utility of IV abatacept in individuals ACPA+ arthralgia patients with subclinical inflammation and showed abatacept to decrease MRI inflammation, clinical symptoms, and risk of future rheumatoid arthritis (RA) development.

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Brazilian registry of 1316 RA pts on bDMARDs or JAKi-Added use of antimalarials reduced SAEs & total AEs, & incr survival. 19% were on HCQ, & had signif less SAEs (mIRR: 0.49); AEs (0.68); serious infections (0.53); hepatic AEs (0.21); & mortality (P=.003) https://t.co/bAZ8m3OBo2 https://t.co/SlneyfbJIh
Dr. John Cush @RheumNow( View Tweet )
Feb 17, 2024
DMARDs, MTX & TNFi can lower CV risk in RA pts. #RWCS24 https://t.co/Un457RYL8R
Dr. John Cush @RheumNow( View Tweet )
Feb 16, 2024
Weight loss is associated with reduced systemic inflammation in RA. If only discussing body composition/obesity/adiposity were that easy for our patients, these changes are hard and non-linear. Dr. Jon Giles #RWCS24 @RWCSmtg @RheumNow https://t.co/vrbBHLz6sL
Dr. Rachel Tate @uptoTate( View Tweet )
Feb 16, 2024

Curbside Consults (2.16.2024)

Feb 16, 2024

Dr. Jack Cush answers audience clinical case questions sent by email or "ask Cush anything". Cases and questions from:



  • Dr. William Hong - RA management in the setting of active TB or latent TB (LTBI)

  • Dr. Vrishali Dalvi - relapsing polychondritis monitoring

  • Dr
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"In solid tumors, treat your RA patient as if they do not have a cancer, meaning do not change your therapy if the patient is responding well. Things may get dicey if hematologic malignancy." @RheumNow #RWCS24 I work w/ my onc team to ensure the patient has the needed support.

Dr. Rachel Tate @uptoTate( View Tweet )

Feb 15, 2024
Steroids are associated with MACE events in RA. #RWCS24 @RheumNow @RWCSmtg https://t.co/U6ssALNspe
Dr. Rachel Tate @uptoTate( View Tweet )
Feb 15, 2024
Who do you watch closely for developing RA? @RheumNow and @RWCSmtg suggest additional risk factors for ratcheting closer to RA. #RWCS24 https://t.co/lV3I5emn72
Dr. Rachel Tate @uptoTate( View Tweet )
Feb 15, 2024
Mayo study of 1643 #RA pts (Dzduration 7 yrs) found 4 clusters based on # of comorbidities (Cluster 1 [42%] few comorbidities & cluster 4 [7%] > 10). Cluster 1 w/ good prog/survival; but cluster 4 was older, less DMARDs/biologics https://t.co/qAWZoXVWlv https://t.co/g3gMsNj848
Dr. John Cush @RheumNow( View Tweet )
Feb 15, 2024

Top 5 Clinical Pearls in RA Management

Feb 15, 2024

RheumNow Live 2024 provided a wealth of clinical insights, particularly in the realm of rheumatoid arthritis (RA) management. Here are the top five clinical pearls from the event's opening session, "Success in Rheumatoid Arthritis."



Dr. Brittany Weber explored the vast field of cardio

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APIPPRA Trial: Abatacept in at-risk rheumatoid arthritis patients

Feb 15, 2024

Abatacept has been studied in seropositive clinically suspect arthralgia patients (at risk for rheumatoid arthritis) and shows the potential to delay or prevent the disease. 



Individuals with serum antibodies to citrullinated protein antigens (ACPA), rheumatoid factor, and arthralgia

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Obesity is assoc w higher CRP. Losing weight lowers CRP RWCS24 https://t.co/Gc6TKtmOgI
Dr. John Cush @RheumNow( View Tweet )
Feb 14, 2024
Higher adipose in RA linked to atherosclerosis but protects against erosions RWCS24 https://t.co/qsFMhj4LyZ
Dr. John Cush @RheumNow( View Tweet )
Feb 14, 2024
Microbiome study (stool- & saliva) in 144 DMARD-naïve RA pts. Samples 6 wks after DMARD Rx. In those achieving MCID, stool microbes decreased (Prevotella, Streptococcus). Baseline microbiota in DMARD-naïve pts indicated future response https://t.co/PQJEp3bNBE https://t.co/jV5SeNd21z
Dr. John Cush @RheumNow( View Tweet )
Feb 13, 2024
14d study of 30 #RA pts collected data from iPhone + Apple smartwatch +PROs showed that AI analysis of sensor data augmented PRO data (by 10%) regarding RA status & severity. Sensor + PRO correlated well w/ RAPID3 status (r2, 0.692) https://t.co/3izpHiqRHG https://t.co/vMvtqOZCjF
Dr. John Cush @RheumNow( View Tweet )
Feb 13, 2024
Brazilian registry of 1316 RA pts on bDMARDs or JAKi-Added use of antimalarials reduced SAEs & total AEs, & incr survival. 19% were on HCQ, & had signif less SAEs (mIRR: 0.49); AEs (0.68); serious infections (0.53); hepatic AEs (0.21); & mortality (P=.003) https://t.co/cOeg3KL8Z3 https://t.co/pPRqD7PkXB
Dr. John Cush @RheumNow( View Tweet )
Feb 12, 2024
Poly-Refractory Rheumatoid Arthritis Refractory of difficult to treat (D2T-RA) rheumatoid arthritis (RA) comprises a minority of patients that can be categorized by clinical and imaging parameters to formulate a better therapeutic approach. https://t.co/IKAojQFdaw https://t.co/paBwWw2nmh
Dr. John Cush @RheumNow( View Tweet )
Feb 12, 2024