Rheumatoid Arthritis

Tofacitinib May Reduce Interstitial Lung Disease Risk in RA

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MedPage Today

Mar 23, 2023

Tofacitinib (Xeljanz) in patients with rheumatoid arthritis (RA) stood out among several other biologic and targeted synthetic disease-modifying antirheumatic drugs (sDMARDs) when it came to the incidence of interstitial lung disease (ILD), a retrospective cohort study showed.

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What to do about pre-clinical RA?

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Robert Chao, MD

Mar 20, 2023

RheumNow Live’s 2023 conference led with this year’s hot topic of rheumatoid arthritis, and in particular, what to do regarding pre-clinical RA.

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Biosimilars are coming! Multiple adalimumab biosimilars this year - will we see a dramatic price difference? @RheumNow #RNL2023 https://t.co/8vdtXtEGOO

Robert B Chao, MD @doctorRBC( View Tweet )

Mar 19, 2023

Will be begin using sputum instead of blood serologies to detect RA? - sputum seropositive CCP may be associated with development of clinical RA - 4 fold higher risk if (induced) sputum CCP+ @RheumNow #RNL2023 https://t.co/Z85GDwIyl8

Robert B Chao, MD @doctorRBC( View Tweet )

Mar 19, 2023

#RNL2023 Year in Review Sputum antibody predicts future development of RA Hazard ratio 4.2 if any sputum antibody positive (CCP IgG/IgA, RF IgM and IgA) Strongest association with CCP IgA Supports pre-RA as mucosal disease @RheumNow https://t.co/Js4JPZiLDB

Eric Dein @ericdeinmd( View Tweet )

Mar 19, 2023

Smoking *may* only ⬆️ risk of #RA if shared epitope present AND double positive By @Janetbirdope #RNL2023 https://t.co/TG1hseVCsD

Dr Gurdeep Dulay @gurdeep_dulay( View Tweet )

Mar 19, 2023

Could MTX every other week dosing be an option in patients with stable disease..? #RNL2023 https://t.co/EZRdQnuXjy

Dr Gurdeep Dulay @gurdeep_dulay( View Tweet )

Mar 19, 2023

Long live the GOAT Rx: MTX 🐐🐐 History of usage dating back to 1950 Use 1st-line Optimize dose Supplement folic acid Split dose Give SQ Use in combination therapy Dr Joel Kremer #RNL2023 @RheumNow https://t.co/CCBvQoNHXo

Eric Dein @ericdeinmd( View Tweet )

Mar 19, 2023

#ClinicalPearl #Methotrexate weekly May reduce side effects in rapidly dividing cells vs using it daily or every few days. GI, oral, bone marrow side effects should be less if once a week. Joel Kremer ⁦@RheumNow⁩ #RNL2023 https://t.co/i0LZoQuK0w

Janet Pope @Janetbirdope( View Tweet )

Mar 19, 2023

How is a biosimilar approved? Comparative effectiveness study for the reason that the medication was initial approved required, not for other indications Jonathan Kay shows ex of ETN-ykro vs reference ETN in RA Non-inferior in immunogenicity, safety, efficacy @RheumNow #RNL2023 https://t.co/OOHie9Qr5t

Eric Dein @ericdeinmd( View Tweet )

Mar 18, 2023

Was amazed at the tons of biosimilar TNF options @_connectedcare uses in Australia... coming soon to the US! Jonathan Kay #RNL2022 shows the lists of biosimilar May be w/in batch-to-batch variability, unintended drift, or deliberate process changes (evolution) @RheumNow https://t.co/sfVQspxbyr

Eric Dein @ericdeinmd( View Tweet )

Mar 18, 2023

Jonathan Kay on #RNL2023: Biosimilar is well-researched with cost savings These savings should benefit the patients Incentives for physicians as well in form of decreased prior auth burdens @RheumNow

Eric Dein @ericdeinmd( View Tweet )

Mar 18, 2023

RBC MTX polyglutamate levels may be the “truth serum” for those pts stating they are taking their MTX but you question it. Dr. Kremer @RheumNow #RNL2023

Dr. Rachel Tate @uptoTate( View Tweet )

Mar 18, 2023

MTX is a prodrug! MTX polyglutamate is true active ingredient 1/2 of MTX PG is 60 days, compared to only 6-8 horus for MTX Steady state is not until 27.5 weeks! Joel Kremer at #RNL2023 @RheumNow https://t.co/hodFZ2oi11

Eric Dein @ericdeinmd( View Tweet )

Mar 18, 2023

Do you stop MTX on patients on bDMARD? MTX decrease anti-drug antibodies on patients on infliximab - increases drug duration. Similar seen with new combination usage with pelogloticase Joel Kremer MD #RhuemNow @RheumNow https://t.co/8UrGZaFStA

Eric Dein @ericdeinmd( View Tweet )

Mar 18, 2023

How do you wean MTX? Consider every other week dosing as options - supported by 2 randomized studies from 1995 and 1999 Option to lower weekly dosing in patients that want to take less often Joel Kremer #RNL2023 @RheumNow https://t.co/3GMdn3lLhy

Eric Dein @ericdeinmd( View Tweet )

Mar 18, 2023

MTX lung disease: Presents at 6-12 months Baseline CXR is key to know if lung infiltrates are new #RNL2023 @RheumNow https://t.co/Whu4O1GLA9

Eric Dein @ericdeinmd( View Tweet )

Mar 18, 2023

Do and don’t around MTX , Dr.Kremer approach to MTX #RNL2023 ⁦@RheumNow⁩ https://t.co/dXLQ0epsp4

Nouf Al hemmadi @NoufAhmedAlham2( View Tweet )

Mar 18, 2023

@Janetbirdope at #RNL2023 RA is not a disease of young Incidence increasing in elderly population, not often offered the full range of medications due to co-morbidities, despite safety data Higher DAS, seroneg Co-morbidities decrease outcomes @RheumNow

Eric Dein @ericdeinmd( View Tweet )

Mar 18, 2023

Myths of RA by Dr. Janet Pope - RA development should have ACPA years before? - there is a significant minority of early RA patients who are seronegative! @RheumNow #RNL2023 https://t.co/pnOxTkfW0l

Robert B Chao, MD @doctorRBC( View Tweet )

Mar 18, 2023

How much of RA risk is attributed to lifestyle? @Janetbirdope presents Nurse's Health Study showing 35% BMI and smoking increase risk of RA... in patients with ACPA positivity #RNL2023 @RheumNow https://t.co/g9DIrgc7pk

Eric Dein @ericdeinmd( View Tweet )

Mar 18, 2023

@Janetbirdope #RNL2023 Benefit of intra-articular jt injections in early RA Injection of 6-12 swollen joints (!) vs systemic glucocorticoids -- FAR better ACR20 and ACR50 with less side effects @RheumNow https://t.co/AtgCKOd8IC

Eric Dein @ericdeinmd( View Tweet )

Mar 18, 2023