Rheumatoid Arthritis

Digital Self Screening for Arthritis Diagnosis A new study evaluates patient use of a mobile AI–based symptom checker for diagnoses, but demonstrated only modest accuracy when applied to a cohort of patients with joint symptoms. https://t.co/YLkheDOrdI https://t.co/MFMEYifP3W

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Dr. John Cush @RheumNow( View Tweet )
RA & OA: Nearly 40% have Anxiety, Depression or Fibromyalgia Researchers at Rush University analyzed clinic MDHAQ data and found between 36-40% of OA and RA patients screen positive comorbid anxiety (ANX), depression (DEP), or fibromyalgia (FM). https://t.co/ZElo9iPfA6 https://t.co/dcE0fAsp2N

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Dr. John Cush @RheumNow( View Tweet )
Biologics Prevent AA amyloidosis progression to ESRD The study suggests that biologic drugs can prevent serious complications of rheumatologic and autoimmune diseases, with some products showing greater effectiveness than others. https://t.co/f04Jrzy9ae https://t.co/O6dgD5RvxZ

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Dr. John Cush @RheumNow( View Tweet )
Bad News Coronary Artery Calcium in Rheumatic Patients In the 2024 SCCT meeting, Dr. Brittany Weber presented findings showing that incidentally discovered CAC in patients with IMID can lead to worse outcomes, even without prior ASCVD. https://t.co/aJhf0IL1WW https://t.co/uMl89rXjBK

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Dr. John Cush @RheumNow( View Tweet )
Earlier RA Diagnosis Leads to Lower Costs of Care A study from the Leiden Early Arthritis Clinic shows that is RA is diagnosed within 12 weeks after symptom onset, treatment costs were lower in both autoantibody-negative and autoantibody-positive RA. https://t.co/TnrpZGZ4fX https://t.co/elNQ3Pde2a

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Dr. John Cush @RheumNow( View Tweet )
2001-2004 NHANES population study shows 28% report hx of erectile dysfunction (ED) & 19% w/ arthritis. Having arthritis was assoc w/ 4 fold higher ED risk; mostly in #OA (OR=1.11), RA (OR=1.03). https://t.co/L2LhEPH9DY https://t.co/yLhVmLw7nt

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Dr. John Cush @RheumNow( View Tweet )
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RA & OA: Nearly 40% have Anxiety, Depression or Fibromyalgia

Jack Cush, MD

Researchers at Rush University analyzed clinic MDHAQ data and found between 36-40% of osteoarthritis and rheumatoid arthritis patients screen positive comorbid anxiety, depression, or fibromyalgia.

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UK Natl Early Inflammatory Arthritis Audit (5/18-10/22) compared 682 persistently active vs 1026 low activity RA pts. pactiveRA were younger, more women. pactiveRA assoc. w/ Age, gender, smoking, depression, lung dz, gastric ulcers, baseline steroids https://t.co/QGuUZmSBHD https://t.co/TDlPFmTQEn

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Dr. John Cush @RheumNow( View Tweet )
Potential of Radiomics to Predict TNF Therapy Outcomes in axSpA Dr. Bella Mehta interviews Dr. Vincenzo Venerito about abstract POS0236 at Eular 2024 in Vienna, Austria. https://t.co/ZR5pFINagR https://t.co/bEWjSXWlB0

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Dr. John Cush @RheumNow( View Tweet )
Inspirations About RA-ILD Dr. Jonathan Kay discusses abstracts POS0070, POS0043 and POS0022 presented at the Eular 2024 meeting in Vienna, Austria. https://t.co/sKwr7yMUcX https://t.co/UBTYD5SioS

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Dr. John Cush @RheumNow( View Tweet )
UK study of pneumococcal vaccination in UK, shows IMID pts had suboptimal vax against pneumococcus. In 32 277 pts (RA 14151, IBD 13631, SpA 3804, SLE 691) saw 57% vaccinated; lower if <45 yrs (32%), IBD (42%). Vax not associated w/ IMID flare https://t.co/y5JHYaEpA9 https://t.co/zUXfDoqyal

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Dr. John Cush @RheumNow( View Tweet )
From LG cohort of myeloid neoplasms (861 MDS, 640 AML, 112 MDS/MPN, 89 MPN) autoimmune Rheum Dz (AIRD) found in 7.7% (lit suggests 8-30%), less in AML (4.7% vs 9.5% others). Common: RA (42%), CTD(18%), PMR (14%), vasculitis (12%), AxSpA (7%). https://t.co/ZXxOrZBunZ https://t.co/m5nIgrhohw

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Dr. John Cush @RheumNow( View Tweet )
Australian Womens survey, from 25 467 responders the prevalence of #RA varies by how defined - 3·9% for self-reported RA, 1·9% based on the medication dispensed, and 0·5% by self-reported medication use definitions. https://t.co/2FUwftajlG https://t.co/4a5CIfw8hS

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Dr. John Cush @RheumNow( View Tweet )
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Bad News Coronary Artery Calcium in Rheumatic Patients

Jack Cush, MD

A recent presentation at the 2024 Society of Cardiovascular Computed Tomography meeting by Brittany Weber MD, PhD (Brigham and Women’s Hospital) has shown that incidental findings of coronary artery calcium on chest CTs in patients with immune-mediated inflammatory diseases may be associated

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Earlier RA Diagnosis Leads to Lower Costs of Care

Jack Cush, MD

A study from the Leiden Early Arthritis Clinic shows that is rheumatoid arthritis (RA) is diagnosed within 12 weeks after symptom onset, treatment costs were lower in both autoantibody-negative and autoantibody-positive RA. 

The rheumatologist

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174 Active RA pts not responding to MTX were started on TCZ. High GM-CSF (> 5 ng/ml and > 10 ng/ml) at baseline were the independent predictors of poor response to TCZ at Wk24. high GM-CSF had signif higher DAS28-ESR & cytokine levels at baseline https://t.co/AreLBseJDq https://t.co/OyIOkiUOT1

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Dr. John Cush @RheumNow( View Tweet )
Problems With Laboratory Tests in the Management of RA https://t.co/kUYivP7SHW https://t.co/nFtB75N0jQ

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Dr. John Cush @RheumNow( View Tweet )
ICYMI: Metrics Used by Rheumatologists in RA https://t.co/7Qr4cYvqp1 https://t.co/1FnyNpfhqi

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Dr. John Cush @RheumNow( View Tweet )
Pain in RA: Different Drugs for Different Mechanisms https://t.co/pOETFkTIkS https://t.co/Vn5zgrYsKR

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Dr. John Cush @RheumNow( View Tweet )
192 RA pts on MTX: GI Sxs studied w/ MISS (MTX intolerance severity score). GI intolerance seen in 56%, Nausea & pain post-MTX most common. More in afro-descendants, w/ FM, Steroids, or JAKi. MISS results unrelated to Route, Gi Dz, age, MTX dose https://t.co/EROmZQo1Zs https://t.co/SOMzzXXj0b

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Dr. John Cush @RheumNow( View Tweet )
IRIS-RA, a failed phase 2 study of Nipocalimab, an anti-FcRn mAb severe active RA not responding to TNFi. 53 seropos. RA pts did not achieve primary endpt of better DAS28-CRP at Wk 12 (but Nipo was numerically better & signif lowered RF, CCP, but not CRP) https://t.co/52HLsfpKLS https://t.co/eEifXA6MpP

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Dr. John Cush @RheumNow( View Tweet )
Does B Cell Depletion Matter? Dr. Yuz Yusof interviews Dr. Ed Vital regarding abstract OP0077 at Eular 2024 in Vienna, Austria. https://t.co/SX7BkX3w1T https://t.co/H1rD0n8GnK

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Dr. John Cush @RheumNow( View Tweet )
174 Active RA pts not responding to MTX were started on TCZ. High GM-CSF (> 5 ng/ml and > 10 ng/ml) at baseline were the independent predictors of poor response to TCZ at Wk24. high GM-CSF had signif higher DAS28-ESR & cytokine levels at baseline https://t.co/vy7czYwv1Z https://t.co/R2cYdNZ3V0

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Dr. John Cush @RheumNow( View Tweet )
Preliminary results from RESET-RA Study announced; demonstrating ACR20 efficacy of implanted vagal nerve stimulation at 12 wks (p=0.0209). 2-staged, multicenter, randomized, sham-controlled, double-blind pivotal trial, enrolled 242 RA pts https://t.co/gIVJd9F6Pk https://t.co/SNjWIa3raB

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Dr. John Cush @RheumNow( View Tweet )
Efficacy of Biologics in Patients with CKD A retrospective cohort study of biological bDMARDs persistence in RA patients w/CKD, shows the 3 year survival to be > 50% but all studied biologics were nearly equivalents with regard to safety and efficacy. https://t.co/rL2ZondUsE https://t.co/1hM237Jl83

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Dr. John Cush @RheumNow( View Tweet )

Recent Blogs

Best of 2023: New ACR RA-ILD Treatment Guidelines – What Were They Smoking!?

Richard Conway, MBBChBAO, PhD
Lungs ILD
Rheumatoid arthritis related interstitial lung disease (RA-ILD) is common, with symptomatic RA-ILD affecting approximately 8% of RA patients. There is a very limited evidence base supporting treatment and therefore the recent release of ACR guidelines is to be welcomed. However, the published guidelines appear discordant with the best available evidence base.  Read Post

Screening and Overdiagnosis of ILD in RA

Michael Putman, MD, MSCI
Putman RheumThoughts
Dr. Michael Putman (Milwaukee, WI) reviews his approach to screening for ILD and RA, the potential for overdiagnosis and how this impacts treatment choices. Does this differ from your approach? Read Post

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