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Autoinflammatory Diseases

Methotrexate-Pegloticase Combination in Refractory Gout - MIRROR Study

Sep 17, 2020

The MIRROR study, an open-label pilot trial in refractory, uncontrolled gout patients, showed that pegloticase given in combination with methotrexate was safe and effective and maintained responses for 6 months after initiation. 

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ACR 2020 Reproductive Guidelines - Lactation Guidance

Sep 10, 2020

In this third excerpt from the ACR guidelines on managing reproductive health issues in rheumatic disease patients, we present recommendations regarding the use of glucocorticoids and guidance on lactation and medication use post-partum.

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RheumNow Podcast – Rheum Lives Matter (8.28.20)

Aug 28, 2020

Dr. Jack Cush reviews the news and journal articles from the past week. Of mice and men in cartilage, the efficacy of JAK inhibitors in patients who are having skin problems, nrAxSpa has its own diagnostic code, metformin, talking about Back Talk, plus so much more.

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Antibiotic use is associated with a higher rate of IBD (aOR 1.88; 1·79–1·98) based on a prospective case-control study from the Karolinska that compared 23,982 new IBD pts w/ 117,827 matched controls followed over 10 years.

Dr. John Cush RheumNow ( View Tweet)

Aug 19, 2020
Study 137 GCA pts (1993 -2015) - those w/ diabetes were less likely to have (+)Tem artery Bx & more likely to relapse. ARB Rx prior to diagnosis showed greater success discontinuing glucocorticoids.

Dr. John Cush RheumNow ( View Tweet)

Aug 18, 2020

Rheumatic Diseases, Drugs and COVID-19 Guidelines

Aug 13, 2020

Several recent publications have focused on the risk and outcomes of rheumatic disease (RDD) and autoimmune patients who become infected with SARs-CoV-2.

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Mortality study of 18,943 patients with PMR and 87,801 matched controls from the Clinical Practice Datalink with 8 yrs of followup finds NO increase in mortality in PMR patients adjusted MRR 1.00 [95% CI 0.97, 1.03]).

Dr. John Cush RheumNow ( View Tweet)

Aug 10, 2020
Hong Kong study Myositis-specific autoantibodies in 201 pts with idiopathic inflammatory myopathies (IIM) shows MDA-5 (14%), TIFF-1γ (14%), Jo-(12.4%). MDA5 seen w/ DM, digital ulcers, amyopathy, ILD.

Dr. John Cush RheumNow ( View Tweet)

Aug 07, 2020
Full read clinical practice guideline on obesity management from the Canadian Medical Assn Journal.

Dr. John Cush RheumNow ( View Tweet)

Aug 05, 2020
Virtual Video Joint Exam Pearl #4: Professor Paul Emery was right! THe MCP squeeze (done by the patient) and MTP squeeze is fairly predictive of RA/inflammatory arthritis AND outperforms the "Finger" (distal hand) squeeze. Hence the MCP/MTP is my main squeeze!

Dr. John Cush RheumNow ( View Tweet)

Aug 04, 2020
Fracture risk & prevalence of osteoporosis is elevated in patients with idiopathic inflammatory myopathies: cross-sectional comparison of 52 myositis and 43 RA pts.

Dr. John Cush RheumNow ( View Tweet)

Jul 31, 2020
French cohort analysis of 104 kids taking Tocilizumab (mostly for Stills dz or polyJIA) shows 25% with serious AE (15.3/100 PY), mostly seriou infections or infusion reactions. at TCZ initiation.

Dr. John Cush RheumNow ( View Tweet)

Jul 27, 2020

RheumNow Podcast – COVID-19 Responds to Steroids (7.24.20)

Jul 24, 2020

Dr. Jack Cush reviews the News and Journal Reports from the past week on

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Systematic review of 100 pts with statin-associated myopathy showed mean age 65 yrs, presenting w/ symmetric prox.

Dr. John Cush RheumNow ( View Tweet)

Jul 22, 2020
45 yr adult male w/ Kawasaki-like multisystem inflammatory syndrome w/ COVID-19 infx: presented w/ 6d fever, sore throat, diarrhea, LN, BLE pain, conjunctivitis, tachycardia, ESR 120, CRP 546 mg/L, high Troponin; Rx and resolved w/ IVIG & TCZ

Dr. John Cush RheumNow ( View Tweet)

Jul 21, 2020

Tocilizumab May Benefit COVID-19 Pneumonia

Jun 29, 2020

A retrospective, observational study published in Lancet Rheumatology has shown that tocilizumab (TCZ) may reduce the risk of death or the need for mechanical ventilation in severe COVID-19 pneumonia. This observational study included adults, with severe COVID-19 pneumonia, who were hospitalized

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ACR Outlines Best Practices for Kids With MIS-C

Jun 25, 2020

Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 infection has both similarities and differences with Kawasaki disease, and requires distinct clinical management, according to draft guidance from the American College of Rheumatology (ACR).

Age, symptoms,

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RheumNow Podcast – Enough Already with Weaning (6.19.20)

Jun 19, 2020

Dr. Jack Cush reviews the news and journal reports from the past week on

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Day 3 - Top 5 from EULAR 2020

Jun 10, 2020

These were my top abstracts from Thursday, 4th of June at EULAR 2020:

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Behcet's ulcers can be a real pain. I've heard pentoxifylline gel be discussed before, here's some early data to back it up (need bigger trial). Tastes terrible, though - so maybe this? (or a commercial prep might solve it) SAT0260 #EU
David Liew drdavidliew ( View Tweet)
Jun 07, 2020
#EULAR2020 Recc for irAEs w/ICI: 1. GC's ok, goal<10 mg/d, any csDMARD, bDMARD (TNFi/IL-6),🚫ABT xcept life-threatening myositis 2. Myositis beware bulbar signs: dysphagia, dysarthria, dysphonia: stop ICIs,⬆️GC, IVIG/PE 3.
Jun 06, 2020
Don’t forget significant fibrosis with ILD has +RCT with nintedanib INBUILD study. Lots of buzz of RA ILD where MTX is OK, TNFi may have more ILD than other bDMARDs, biomatkers KL-6 @eular_org OP0038 #EULAR2020 @CRASCRRheum
Janet Pope Janetbirdope ( View Tweet)
Jun 06, 2020

EULAR and ACR COVID19 Guidelines: Similarities Provide Reassurance

Jun 05, 2020

In difficult times, it's reassuring to reflect on the similarities that bring us together. In the case of the EULAR and ACR COVID19 guidelines as discussed at #EULAR2020 by Drs. Mikuls and Landewe, the recommendations from both panels proved to be reassuring with a hint of "we are flying

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TNR Grand Rounds - Update on Biosimilars

Jun 03, 2020

This week's Tuesday Nite Rheumatology featured Dr Jonathan Kay (U Mass) who gave an update on Biosimilars and took questions the subject. The program was moderated by Dr. Jack Cush.

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First Look at COVID-19 Global Rheumatology Alliance Registry

Jun 01, 2020

Gianfresco et al have published the first peer-reviewed analysis of COVID-19 infected, rheumatic disease patients entered into the Rheumatology Global Alliance registry; showing that a) rheumatic disease patient can be infected with COVID-19, b) that DMARD and biologic use has no apparent effect

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