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Biologic/Novel Rx

RheumNow Podcast – Lupus Delights (9.18.20)

Sep 18, 2020

Dr Jack Cush reviews the news and journal reports from the past week on RheumNow.com:

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Belimumab Effective in Lupus Nephritis

Sep 16, 2020

Dr. Rich Furie has lead a group of investIgators in reporting the significant efficacy of intravenous belimumab when added to standard of care induction therapy in patients with active lupus nephritis. This phase 3, 2-year study included 448 systemic lupus erythematosus patients with biopsy

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Uncontrolled retrospective observational study of 31 RA-ILD DMARD refractory pts treated with RTX showed RTX to reverse the PFTs decline (∆%pFVC +8.06%; ∆%pDLCO +12.7%) while reducing median prednisone dose at 1 yr. @32 mos, 74% still on RTX.

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Sep 16, 2020
post hoc analysis of Xrays in tocilizumab poly JIA pts Rx for 2 years in the TENDER and CHERISH trials, shows Tocilizumab may delay radiographic progression in children with sJIA and children with pcJIA with only 3-12% showing xray progression by 2 methods https://t

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Sep 14, 2020
New data on tocilizumab in pregnancy, upshot is: "Tocilizumab concentrations in cord blood and infant serum were 80–90% of those in maternal serum" https://t.co/SEmyTnL7dy

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Sep 12, 2020
117 pregnancies exposed to biologics were compared to 585 pregnancies not exposed to biologics; 6% of newborns had ≥1 congenital anomalies. No significant association between biologic exposure and congenital anomalies (HR 1.06; 95%CI 0.46-2.47) was seen.

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Sep 11, 2020

RheumNow Podcast - ACR Reproductive Health Slides (9-11-20)

Sep 11, 2020

Dr. Jack Cush reviews the 2020 ACR Reproductive Health Guidelines presented all week here on RheumNow. 

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Systematic review of Paternal DMARD exposure prior to pregnancy shows no firm evidence of harm with TNFi, ABA, RTX, azathioprine, cyclosporine, HCQ, leflunomide, MTX or mycophenolate mofetil.

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Sep 11, 2020

ACR 2020 Reproductive Guidelines - Lactation Guidance

Sep 10, 2020

In this third excerpt from the ACR guidelines on managing reproductive health issues in rheumatic disease patients, we present recommendations regarding the use of glucocorticoids and guidance on lactation and medication use post-partum.

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Small study of 25 pregnancies in RA compared those who continued biologics till conception vs those who stopped before conception. Continuing biologics till conception lead to a significantly shorter time to pregnancy. https://t.co/x9EptzkvYr

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Sep 10, 2020

ICYMI - The Pregnancy & Lactation Labeling Rule Explained

Sep 10, 2020

A recent article from Healio.com reviewed the FDA’s Pregnancy and Lactation Labeling Rule (PLLR) that became effective June 30th. This rule applies only to currently marketed prescription drug products available in the United States and does not affect the labeling of drug products available

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ACR 2020 Reproductive Guidelines - Medication Use with Pregnancy

Sep 09, 2020

The American College of Rheumatology (ACR) has published guidelines to manage reproductive health issues in rheumatic disease (RMD) patients before, during and after pregnancy. In this second exerpt from their guidelines articles we present recommendations (and good clinical practice

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Free full read review "Postnatal Care of Woman with Rheumatic Dz". 46% of RA pts will flare postpartum; breast feeding is ok w/ most biologics; Hold Live vaccines if Pt is on a biologic during pregnancy; VTE prophylaxis essential for 10 d–6 wks postpartum.

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Sep 09, 2020
QD Videos from RheumNow Live. "I wanna get pregnant" (a controlled RA patient on tocilizumab) https://t.co/vfLgQPrl98

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Sep 09, 2020

ICYMI - 11 Pearls for Pregnancy Management in Rheumatoid Arthritis

Sep 09, 2020

Rheumatoid arthritis affects women in their child-bearing years and many will face the issue of pregnancy and RA management at some point. Here are11 considerations for those managing RA patients who wish to become pregnant.



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ACR 2020 Reproductive Guidelines - Contraception & Counseling

Sep 08, 2020

The American College of Rheumatology established a guidelines committee that consisted of both patients, rheumatologists and maternal-fetal health experts. After a a systematic review of the medical literature regarding contraception, assisted reproductive technology, fertility preservation,

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RheumNow Podcast – To Celiac Test or Not? (9.4.20)

Sep 04, 2020

Dr Jack Cush reviews the news, journal articles and takes a few Back Talk questions this week:

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Treatment Options for Extraintestinal IBD

Sep 03, 2020

Extraintestinal manifestations (EIMs) frequently accompany inflammatory bowel disease, often augmenting morbidity and mortality are associated with disease activity and may increase the need for surgery or treatment escalation.  A recent review in GUT details the treatment options for patients

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Early Cardiovascular Benefits to DMARD Treatment in Rheumatoid Arthritis

Sep 01, 2020

ARD has published a report showing that patients with early rheumatoid arthritis have cardiovascular disease that is modifiable with conventional and aggressive therapy and that it did not matter if first line DMARD therapy was with a tumour necrosis factor-inhibitor or methotrexate.

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Comparative retrospective study of 251 ANCA+ pts with AAV (MPA or GPA) & severe renal Dz induction Rx with CYC or RTX, +/- PLEX. Remission equally achieved by CTX or RTX; addition of PLEX did not change outcomes.

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Sep 01, 2020
AbbVie has submited Regulatory Application to FDA and EMA for upadacitinib proposed indication to treate active Ankylosing Spondylitis https://t.co/RPaOXCarEZ

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Aug 28, 2020

RheumNow Podcast – Rheum Lives Matter (8.28.20)

Aug 28, 2020

Dr. Jack Cush reviews the news and journal articles from the past week. Of mice and men in cartilage, the efficacy of JAK inhibitors in patients who are having skin problems, nrAxSpa has its own diagnostic code, metformin, talking about Back Talk, plus so much more.

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Treatments Differ Across Centers in Systemic JIA

Aug 26, 2020

Significant variations were seen across hospitals in the treatment of children admitted with new-onset systemic juvenile idiopathic arthritis (JIA), despite increasing evidence of the efficacy of biologics and the hazards of extended glucocorticoid exposure, a retrospective cohort study found

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Successful treatment of refractory palmoplantar psoriasis in a psoriatic arthritis patient with the JAK inhibitor tofacitinib https://t.co/bdhppoUkmz

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Aug 26, 2020

Update on Polymyalgia Rheumatica and Giant Cell Arteritis

Aug 24, 2020

JAMA has published a clinical update of recent studies on GCA. While PET/CT scanning are novel means of demonstrating activity, they have not changed the diagnostic approach to GCA or PMR and although there are no new proven treatment strategies for PMR beyond glucocorticoids, the FDA has

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