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Education/ACR/EULAR

9 Facts about Leflunomide Medscape has published an informative review of leflunomide, drawn from Dr. Eric Ruderman’s recent lecture on the subject at the February RWCS meeting in Maui. https://t.co/X9lyrOs3D7 https://t.co/TGh2LnGdJ8
Dr. John Cush @RheumNow( View Tweet )

Ides of March (3.15.2024)

Dr. Jack Cush has advice for Caesar and the superstitious, and covers pregnancy, platelets, dialysis and vaccinations in Lupus.





  1. Dutch study of 586 RA pts on bDMARDs found more nonserious infections (NSIE) (77/100PYs) than serious infx (SIE)(1.3/100Pys). Upper respiratory

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MMWR: Vaccination and Multisystem Inflammatory Syndrome in Children

CDC

Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious condition typically occurring 2–6 weeks after SARS-CoV-2 infection and characterized by fever and multiorgan involvement.  The current MMWR report shows that MIS-C case numbers have decreased by 98% since 2021.

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Depression and RA (3.8.2024)

Dr. Jack Cush reviews the news, journal reports and regulatory approvals from the past week.

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Lyme Disease 2022

The CDC has updated its Lyme disease surveillance report based on a new case definition. Compared to 2017–2019, the number of cases in 2022 rose by 69%.

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Polyautoimmunity in RA, Regardless of ACPA Positivity

While it is believed that autoimmunity follows autoantibody positivity, a Danish study shows the incidence of polyautoimmunity to be similar in rheumatoid arthritis (RA) patients who are either anticyclic citrullinated peptide antibody (ACPA)–positive or ACPA–negative. 



Data was

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19% Arthritis Prevalence in the USA

According to the National Health Interview Survey (NHIS), in 2022, the prevalence of diagnosed arthritis in adults was 18.9% (women 21.5%, more than men 16.1%). These numbers are down since the CDC's MMWR report of 2019–2021, where is was estimated 21.2% of U.S. adults (53.2 million) had

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12 Best Hospitals in the USA according to Newsweek 1 Mayo Clinic 2 Cleveland Clinic 3 Johns Hopkins 4 MGH 5 UCLA Med Center 6 Stanford Hospital 7 Brigham & Womens 8 Mount Sinai NYC 9 Northwestern 10 University of Michigan 11 Cedars-Sinai 12 UCSF https://t.co/AJnJsWr4eY https://t.co/M2Abicf4eD
Dr. John Cush @RheumNow( View Tweet )
Sniffles & Arthritis (3.1.2024) Dr. Cush reviews the news and journal reports from the past week on RheumNow. Are these associations with infection, biomarkers and weather real or imaginary? Linked or luck? Causal or casual? You decide.... https://t.co/xqoaycXeIm https://t.co/zQdXoj680T
Dr. John Cush @RheumNow( View Tweet )

COVIDs Extended Risk for Rheumatic Disease

EurekAlert!

Annals of Internal Medicine reports a large, binational study finding SARS-CoV-2 infection was associated with an increased risk for autoimmune inflammatory rheumatic diseases (AIRDs) that extends up to 12 months after

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Machine learning of 701 Anti-Synthetase (Anti-Jo1, -PL7, -PL12, -EJ) identifies 3 Endotypes,independent Ab specificity #1 (24%) w/ RP-ILD & high mortality #2 (14%) dermatomyositis, intermediate prognosis #3 (62%) arthritis & mechanics hands, good prognosis https://t.co/y9LMCfMIgN https://t.co/y0MbYlbbrV
Dr. John Cush @RheumNow( View Tweet )
When Meningitis Strikes Twice Amanda Moyer, MD, presents her poster at RWCS 2024. https://t.co/hO8VkcqCkb https://t.co/9tfKI7dEs9
Dr. John Cush @RheumNow( View Tweet )
It's a Sore Subject Cindy Chiu, DO, presents her poster at RWCS 2024. https://t.co/Bl7mAL4grR https://t.co/9rLglObu4V
Dr. John Cush @RheumNow( View Tweet )

Sniffles & Arthritis (3.1.2024)

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. Are these associations with infection, biomarkers and weather real or imaginary? Linked or luck? Causal or casual?  You decide....





  1. No clear link between weather & MSK symptoms

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Many with Psoriatic Arthritis Fail to Achieve Minimal Disease Activity

Despite the availability of numerous advanced therapies for psoriatic arthritis (PsA), there remains a substantial burden and unmet need for improved therapies, according to a newly published Canadian study.

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Polyarteritis Nodosa: Clinical Features and Outcomes

A multinational study of polyarteritis nodosa (PAN) through the international GLOBAL-PAN network shows PAN to be a complex, multisystem disorder with a high risk of relapse and low risk of death (11% at 10 years).

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Mastery of knee arthrocentesis for internal medicine resident Brian D. Jaros, MD, presents his poster at RWCS 2024. https://t.co/xFoEGnj2QH https://t.co/DpW07jJTLf
Dr. John Cush @RheumNow( View Tweet )

Behçet’s Syndrome

A comprehensive overview of Behcet's syndrome appeared in last week's NEJM, reviewing the numerous advances in the immunogenetics, syndrome recognition, and targeted therapeutic approaches. Despite certain advances, there remains a need for better clinical trials, better diagnostic tools, and

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Eating for RA The majority of practicing rheums at RheumNow Live were unaware of the new ACR guidelines issued in 2022 regarding dietary and lifestyle recommendations for patients with RA. Dr. Monica Guma reviewed these guidelines during her lecture. https://t.co/9herN2musx https://t.co/P1xJn2lDrg
Dr. John Cush @RheumNow( View Tweet )
Vasculitis Pearls Once again RheumNow Live 2024 really delivered with high impact learning packed into short sessions. As someone with an interest in vasculitis it was fantastic to see four of my favorite speakers in the Vasculitis Mavens and STEP talks https://t.co/Oee5nRhTAx https://t.co/sJGwCzLUQq
Dr. John Cush @RheumNow( View Tweet )

Immunosuppression Increasing (2.23.2024)

Dr. Jack Cush reviews the news and journal reports from the past 2 weeks on RheumNow.com; but begins with a discussion of what constitutes "immunosuppression" and how it applies to our patients.





  1. 2021 NHIS Survey data suggests the prevalence of immunosuppression in the USA

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Cochrane Review: How Good is Ultrasound Diagnosing GCA?

Is temporal artery ultrasound equivalent or superior to the reference standard of temporal artery biopsy when diagnosing giant cell arteritis (GCA)?

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Vasculitis Pearls

Once again RheumNow Live 2024 really delivered with high impact learning packed into short sessions. As someone with an interest in vasculitis it was fantastic to see four of my favorite speakers in the Vasculitis Mavens and STEP talks. They gave us what we really want from these talks –

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Gut microbiota in SpA. Interesting data from @RWCSmtg @JointMD regarding the gut microbiome, both shared and distinct, in SpA, non-infectious AAU and Crohn's. #RWCS24 @RheumNow https://t.co/tHGl01WJ1o
Dr. Rachel Tate @uptoTate( View Tweet )
Combo IL-23 and TNFi synergistic benefit in UC in the proof-of-concept VEGA trial. More data to come! #RWCS24 @RWCSmtg @RheumNow https://t.co/FgLTR2PBYJ
Dr. Rachel Tate @uptoTate( View Tweet )