Day 4 Report from ACR21
Nov 10, 2021
My favorite three presentations from day 4 (Tuesday) at ACR 2021 included the following.
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#ACR21 is complete--view all our RheumNow's coverage.https://t.co/wkZ66lcB44
Links:
Dr. John Cush @RheumNow( View Tweet )
Nov 23, 2021
Geriatric Rheumatology:Improving care of aging patients
Dr.Kathryn Dao ( @KDAO2011) moderates a panel w/ Drs.Una Makris, Katherine Wysham, Sebastian Sattui + Devyani Misra, as they discuss aspects of improving care of/outcomes for aging patients. #ACR21 https://t.co/lF3yUZBEkd https://t.co/hYufA8ptqj
Links:
Dr. John Cush @RheumNow( View Tweet )
Nov 19, 2021
Data from ASN Kidney Wk 2021; US Renal Data System of 275,651 dialysis pts - 15% had gout Vs 85% without gout; Gout pts were older, more male, obese, had more hospitalizations (66 vs 57%), mortality, more CVD, PVD and MI https://t.co/m1d0SJEJjw
Links:
Dr. John Cush @RheumNow( View Tweet )
Nov 18, 2021
Gout being sneaky🧐
Common consult question is "infection or flare?" in patients with gout.
@ACR21 ABS0467 w/ Dr Michael Toprover:
🔸Calibrating DECT for LS-spine in gout patients.
🔹DECT signal = MSU deposition?
🔸Future data on back pain/gout flare/MSU🤞?
@RheumaRepublic https://t.co/aDCusqBk8G
Bonnia Liu @bonnialiu( View Tweet )
Nov 09, 2021
Important #gout study (I'm biased): allopurinol is non-inferior to febuxostat with regards to gout flare when used in a T2T approach, with no differences in AEs, including CV risk. 99% achieved serum urate target over course of trial. Key slides following. #ACR21 https://t.co/tWeGvZ4rKY
Tuhina Neogi, MD, PhD @Tuhina_Neogi( View Tweet )
Nov 09, 2021
We may be getting a new urate lowering therapy. Tigulixostat is a non-purine selective xanthine oxidase inhibitor. Nothing worrying on safety. But I think febuxostat is probably more effective than this? Abstr#L05 #ACR21 @RheumNow https://t.co/Lg0slMlah2
Richard Conway @RichardPAConway( View Tweet )
Nov 09, 2021
Advantages of treat to target (of serum urate) beyond less gout flares? Maybe equal to ⬇️MACE events - I hope in long term less MACE due to less ⬆️CRP w flares. Modelling observational study abst#L06 #ACR21 #ACRBest @RheumNow below is comparative safety T2T better than usual care https://t.co/95M6lNX416
Janet Pope @Janetbirdope( View Tweet )
Nov 09, 2021
#ACR21 L05. Tigulixostat - non-purine selective XO inhibitor for gout
⭐️Effectively brought down serum uric acid <5, dose-dependent
⭐️10% pts gout flare with urate lowering
@Rheumnow https://t.co/LgwkAQ1wg8 https://t.co/G8CxdGcVOQ
Links:
Eric Dein @ericdeinmd( View Tweet )
Nov 09, 2021
#ACR21 L06 Comparative Safety of Gout "Treat-to-target" and "Usual Care" Treatment Strategies on Cardiovascular Outcomes Using Observational Data: Causal Inference Approach https://t.co/4qo49lpBrt Video interview (https://t.co/k8PHCPaF1r) https://t.co/D4G2Ylkelm
Links:
Kazuki Yoshida @kaz_yos( View Tweet )
Nov 08, 2021
8M415 Gout Imaging Advances: Ralf Thiele on US🔊and DECT
US>DECT: DECT needs a minimal density of MSU; DCS, tophi <2mm, liquid tophi may not be detected; US can show hyperemia
DECT>US: DECT can show areas that may be overlooked from standard protocols
💡Bonus:stay around for Q&A https://t.co/G7yQaj9fHw
USSONAR @USSONAR_Rh( View Tweet )
Nov 08, 2021
Dr Stewart @TonyMerriman2 report in 16,000 patients that repeat serum urate testing not superior to single measure in predicting incident gout over 9 years. Makes sense in general, maybe different in those with medication changes etc? Abstr#1449 #ACR21 @RheumNow https://t.co/69NofMNuB8
Richard Conway @RichardPAConway( View Tweet )
Nov 08, 2021
Rush on over to ‘DASH’ diet to ⬇️women at risk for gout abst#0991 #ACR21 @RheumNow it is low salt diet and ⤵️serum urate and HTN https://t.co/smQgVpV3BD
Janet Pope @Janetbirdope( View Tweet )
Nov 07, 2021
In general low health literacy has ⬆️association with non adherence in chronic disease Rx including gout prevention but many other reasons for non adherence cross the health literacy divide. Ex use of alternative Rx, denial, side effects, advice from non HCPs #ACR21 @RheumNow https://t.co/mIIndW1FnV
Janet Pope @Janetbirdope( View Tweet )
Nov 07, 2021
#ACR21 Rheum Secrets and Pearls
Is it Allopurinol or adherence concern?
Oxypurinol can be helpful in measuring adherence!
Kolfenbach: "I despise the term non-compliant patient." Address the many reasons why adherence may be low! Health literacy is key.
@Rheumnow https://t.co/CPJ8kvqcCm
Eric Dein @ericdeinmd( View Tweet )
Nov 07, 2021
DECT (dual energy CT) very helpful to distinguish gout from other crystals and give volumetric measurements using color-coded images... So do we need to do arthrocentesis to diagnose gout anymore? #ACR21 https://t.co/kn2IpXP870
TheDaoIndex @KDAO2011( View Tweet )
Nov 06, 2021
Pearls on gout:
👉Gouty tophi can appear in the L spine and destroy the facet joints
#ACR21 Radiology Bootcamp with Dr. Brindle. https://t.co/ml2uI9f10v
TheDaoIndex @KDAO2011( View Tweet )
Nov 06, 2021
Erosive polyarticular chronic tophaceous gout
Regional Winner of East Asia and Pacific
Image Competition: Rheum Dz in Patients of Color #ACR21 @rheumnow https://t.co/1wrNAhjsw6
TheDaoIndex @KDAO2011( View Tweet )
Nov 06, 2021
Treat-to-Target Works in Gout With No Cardiac Toxicity
ACR
Nov 04, 2021
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that allopurinol and febuxostat may effectively lower urate levels when used in a treat-to-target approach. Importantly, both urate-lowering therapies were very effective with 90% of
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Industry Abstract Previews #ACR21 - Horizon, Aurinia, AstraZeneca
Nov 04, 2021
The pharmaceutical companies will feature the results of their pivotal clinical trials and data analyses at ACR Convergence 2021. Below is a listing of some of their best studies for you to review and look for in the meeting. Often these become the pivotal studies for regulatory approval and
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Primary care docs: please remember that it is not enough just to treat the acute gouty episode. This truly is a chronic debilitating disease #MedEd #gout https://t.co/lXTIqZXA1m
Yousaf Ali MD @yousafali_md( View Tweet )
Oct 30, 2021
Beautiful, isn’t it? https://t.co/Ga0840KBcW
Alla Ayten @alla_ajten( View Tweet )
Oct 30, 2021
Diagnositic Imaging comparison in 36 acute Gout vs CPPD pts:
- Better: MSK US sensitivity/specificity for gout 92%/83% & 91%/92% for CPPD
- Less: DECT sensitivity/specificity for gout 63%/92% & 55%/92% for acute CPPD https://t.co/Ee2MFb8qyl
Links:
Dr. John Cush @RheumNow( View Tweet )
Oct 12, 2021
RheumNow Podcast – #ACA: Ask Cush Anything (10.8.2021)
Oct 08, 2021
Arthritis numbers are rising, and people are finally talking about osteoarthritis. Also, ACR 2021 is just a few weeks away - are you ready? Finally, I'll review cases and questions submitted by viewers in Ask Cush Anything (#ACA). This, and nearly a dozen news items and reports, are discussed in
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Prevalence of Arthritis Rising in the USA
MMWR
Oct 07, 2021
The latest CDC estimates of the national prevalence of arthritis and arthritis-attributable activity limitations (AAAL) show a continued increase in absolute number: 58.5 million (23.7%) U.S. adults have arthritis, 25.7 million (43.9%) of whom have AAAL.
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