Gout

Systematic review of colchicine and pregnancy in #FMF pts included 25 studies. Miscarriage was not increased w/ colchicine in FMF (RR 0.87). Birth defects were similar to unexposed pts (range 0.6% to 4.0%). Colchicine showed no effects (men/women) on fertility. 1 study reported… https://t.co/axiH9jhEJr https://t.co/oBpew71fZw
Dr. John Cush @RheumNow( View Tweet )
Indigenous peoples of the Pacific, particularly those of Polynesian descent, have a high prevalence of hyperuricaemia and gout. Gout in Indigenous peoples of the Pacific is severe, associated with family history and is experienced at a relatively young age.… https://t.co/phf5RRkJzE https://t.co/q4VO34Ea5z
Dr. John Cush @RheumNow( View Tweet )
Available the first time: https://t.co/4UQlqwujiR 2025 On Demand! On Demand gives you access to all lectures, Q & A panels, and STEP talks, and all speaker slides and handouts — all packed with insights you won’t find anywhere else. Non-CME, practical, and finally here.… https://t.co/qZb8OKjPpw https://t.co/Exr8u6QkNc

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The Cartel is Coming for Rheumatology

Eric Dein, MD

"What Do Blockbuster Drugs & The Black Market All Have in Common?" asked Dr. Madelaine Feldman at RheumNow Live 2025. They thrive, she explained, on market exclusivity "... until they don't." At first glance, the pharmaceutical marketplace may not appear like a crime drug ring, but Dr.

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Pregnancy is 🔥 inflammatory Hard to interpret MRI of SI joints in setting of pregnancy Ideally, don't score MRI during pregnancy or 1 year afterwards, would be affected by the pregnancy If needed for clinical eval, focus on structural lesions like erosions #RNL2025 @RheumNow

Eric Dein @ericdeinmd( View Tweet )

Proinflammatory Diet Increases Gout Risk Some dietary habits are worse than others when it comes to gout risk for women, a large study indicated. https://t.co/DS6JDfJZI4 https://t.co/U3Xwq96oGj

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Dr. John Cush @RheumNow( View Tweet )
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Participation is Up! (1.31.2025)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. We also have two call-in cases on "Ask Cush Anything".

Be sure to join in the fun at RNL 2025 next weekend - Gong Show Karaoke; what will you sing?

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SubAnalysis of STOP Gout Trial: 277 pts w/ CKD received either allopurinol or febuxostat. Most achieved SUA goal (79% vs 81%), fewer allopurinol pts had gout flares (32% vs 45%; P=0.02); AKI only seen stage w/ 3 CKD (allopurinol > febuxostat) https://t.co/wwfVCei4Ej https://t.co/W8Y7KxcSd4

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Dr. John Cush @RheumNow( View Tweet )
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Proinflammatory Diet Increases Gout Risk

MedPage Today

Some dietary habits are worse than others when it comes to gout risk for women, a large study indicated.

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Open label trial of starting MTX in 11 uncontrolled gout pts previously Rx w/ IV pegloticase (PEG 2-27x) showed if gout pts failed PEG monotherapy, only 1/11 (9%) showed a good response to adding MTX w/ PEG. MTX must be started w/ PEG initiation to work https://t.co/aoBtyIRbQe https://t.co/RNe03O6Z1N

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Dr. John Cush @RheumNow( View Tweet )
Febuxostat (ULORIC) is discontinued by the manufacturer in the USA. This week an FDA update on drug shortages list announced Uloric has been discontinued. Takeda sited dropping sales, generic competition, and CV safety concerns in the last decade. GENERIC febuxostat should still… https://t.co/QcUNCUFfvJ https://t.co/oBdwkcN177
Dr. John Cush @RheumNow( View Tweet )
post hoc analysis of 4 registration trials of pegloticase, show rates of MACE and Thromboembolic Events were Infrequent (<1.5%; 35.4 events/1000 PY), similar to general gout population (31.7 events/1000 person-years) https://t.co/v6ZqtL4yB2 https://t.co/NA0j20Oew2

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Dr. John Cush @RheumNow( View Tweet )
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Weak Data (1.24.2025)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from RheumNow.com, and features Dr. Charity Dean, the Keynote speaker at RheumNow Live 2025, and why she is an inspiration.

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Do Rheumatologists Follow 2020 ACR Guidelines on Gout?

Jack Cush, MD

Schlessinger and colleagues report that US Rheumatologists generally adhere to and agree with the 2020 American College of Rheumatology (ACR) Guideline for the Management of Gout, although knowledge gaps and practice variance exists.

A total of 201 US

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Population survey study of 933 gout pts (mean 58 yrs, 76% male,80% white) found total gout flare burden = 6.6 gout flares per year. Nearly 72% of gout flares were not reported, pretreated or prevented. Those less likely to report flares were young, less school, lower CCI, less… https://t.co/Z7KWk1YEFH https://t.co/0jDGNMOKjj
Dr. John Cush @RheumNow( View Tweet )
Does Colchicine Lower Gout Mortality Risk? Data from a large UK database finds that gout patients starting urate-lowering therapy (ULT) will benefit from added colchicine prophylaxis by having fewer cardiovascular events. https://t.co/89BXT5OnVS https://t.co/N4IQzRpcPk

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Dr. John Cush @RheumNow( View Tweet )
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Alive in 2025 (1.10.2025)

Jack Cush, MD

Dr. Jack Cush brings in the new year with a review of the latest from RheumNow.com

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Does Colchicine Lower Gout Mortality Risk?

Jack Cush, MD

Data from a large UK database finds that gout patients starting urate-lowering therapy (ULT) will benefit from added colchicine prophylaxis by having fewer cardiovascular events.

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Benefit of Achieving Target Serum Urate Levels in Gout with Chronic Kidney Disease A cohort study of gout patients with CKD stage 3 found that lowering serum urate (SUA) level to less than 6 mg/dL, lowered the risk for severe or end-stage kidney disease progression.… https://t.co/NsGUGvb5L5 https://t.co/QPBWA4VqTo
Dr. John Cush @RheumNow( View Tweet )
12 mos study of RCT 179 gout pts starting allopurinol finds that betw mos 6-12, gout flares went down. 38% had no flares, 19% had 1 flare, & 43% had >1 flare in 2nd 6 mos. # flares equates to control and impact of gout on outcomes. https://t.co/TMwXZStbJU

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Dr. John Cush @RheumNow( View Tweet )

Sedentary Behavior Increases the Risk of Gout NHANES national survey study shows that sedentary behavior is an independent risk factor for gout, especially in those without hyperuricemia. https://t.co/LDhK3iDnrS https://t.co/z6I6tRw9Fr

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Dr. John Cush @RheumNow( View Tweet )
gout target T2T

Benefit of Achieving Target Serum Urate Levels in Gout with Chronic Kidney Disease

Jack Cush, MD

A cohort study of gout patients with CKD stage 3 found that lowering serum urate (SUA) level to less than 6 mg/dL, lowered the risk for severe or end-stage kidney disease progression.

The study included patients drawn from a general practice database (IQVIA Medical Database) between

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ICYMI: VITAL Info on Autoimmune Disease (2.9.2024)

Jack Cush, MD

Dr. Jack Cush reviews the journal reports from the past week on RheumNow.com. Highlights are summarized by three songs: "Stairway to Heaven", "You're No Good", and "How Long (has this been going on)".

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Sedentary Behavior Increases the Risk of Gout

Jack Cush, MD

NHANES national survey study shows that sedentary behavior is an independent risk factor for gout, especially in those without hyperuricemia. 

The increasing prevalence of

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#ACR24 Year in Review: 💡GLP1i significantly decreased knee OA pain over time (or was it the wt loss itself?🤨) 💡CD19 CAR T-Cell therapy has potential to treat/cure many autoimmune diseases (are risks and $ worth the benefit?) 💡 High risk of CV events within 30 days of gout… https://t.co/g3egOpCYNr https://t.co/KMiOEP7pSg
Dr. John Cush @RheumNow( View Tweet )

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