Seronegative RA Disease Activity (7.17.2026)
Dr. Jack Cush reviews the news, journal articles and Gout features from this past week on RheumNow.com
Read Article
Optimize the therapies you use every day.
Join leading gout experts as they discuss practical strategies for treat-to-target, adherence, and managing complex Gout patients.
Drs: Ted Mikuls, Michael Pillinger, and Lisa Stamp
Moderated by: Dr. Jack Cush
Gain practical insights https://t.co/47NoiPR6GG
Dr. John Cush @RheumNow( View Tweet )
Why Do Gout Flares Start at Night?
The striking propensity for gout flares to initiate at night has been recognized for centuries. More recent epidemiological research supports this observation, indicating that the risk of a gout flare is more than twice as high in the early https://t.co/FbCUmXEl2y
Dr. John Cush @RheumNow( View Tweet )
Rheumatoid arthritis is found in 2-3.8% of gout patients.
For more gout content, follow our Gout: More than Flares campaign at https://t.co/lQoiFjubZJ, https://t.co/moAOVUJjKZ
Dr. John Cush @RheumNow( View Tweet )
QD Clinic: Allopurinol for All Gout? Not Quite
Dr. Brian Jaros, Chicago, discusses the use of allopurinol.
https://t.co/XENBDqZ2Z6 https://t.co/KFTZwuYVLI
Dr. John Cush @RheumNow( View Tweet )
QD Clinic: When There's Doubt in Gout
Dr. Eric Dein discusses how imaging was used in correctly diagnosing a mid-foot symptom in gout.
https://t.co/FNI6rlOz1O https://t.co/Xpw98DiEvs
Dr. John Cush @RheumNow( View Tweet )
Gout Imaging in Care
Gout is all about the crystals and the consequences of the disease are due to the inflammation they cause. Getting rid of urate crystals is the ultimate goal in gout, as we now know that it leads to the risk zero of flares and it normalizes the https://t.co/DGuiTOtQFa
Dr. John Cush @RheumNow( View Tweet )
Saliva and Uric Acid Testing
A recent report from China reaffirms the potential utility of salivary uric acid (UA) testing delivers smartphone-guided, enzyme-free gout screening at home for pennies per test.
https://t.co/VtvJuPNEWA https://t.co/pdBmy5JoQd
Dr. John Cush @RheumNow( View Tweet )
Four Things About Allopurinol Hypersensitivity Syndrome
Dr. Robert Terkeltaub discusses allopurinol hypersensitivity syndrome in gout patients.
https://t.co/5seiyfVLW1 https://t.co/0A1Rtk9hzS
Dr. John Cush @RheumNow( View Tweet )
The Marriage between Gout and the Kidney
While the link between uric acid and gout was first described by Alfred Baring Garrod in the 1800s, the proof that uric acid might actually be the cause had to await the self-experimentation of two rheumatologists from the University of Pennsylvania. Given some comments that the presence of
Read Article
Gout in Minority Populations
Gout is the most common inflammatory arthritis, but its burden is not shared equally across populations. Recent research has revealed substantial racial and ethnic disparities in both who develops gout and the care patients receive. These differences reflect not only genetic susceptibility but
Read Article
In 2010 Colchicine fell under patent protection and price increased 16 fold, & out-of-pocket price increased 4.4-fold, colchicine use decreased 27%, while allopurinol, steroid & gout visits (ER, Rheum) increased. https://t.co/xyOxsnoM5z https://t.co/yoXehV0mPa
Dr. John Cush @RheumNow( View Tweet )
Gout Cavalcade (7.10.2026)
Dr. Jack Cush reviews the news, journal articles and regulatory decisions from the past week. July is Gout: More than Flares month.
https://t.co/I1zWdx9fzU https://t.co/EYQ3D9Z42t
Dr. John Cush @RheumNow( View Tweet )
Why Do Gout Flares Start at Night?
The striking propensity for gout flares to initiate at night has been recognised for centuries. In 1683, Thomas Sydenham famously observed that the typical patient "goes to bed and sleeps in good health" only to be awakened around 2:00 AM by excruciating pain. More recent
Read Article
While not a validated Dx tool for gout, AI retinal scanning of digital fundus photography was tested on 107730 pts & showed high ROC - f NIDDM 0.833, Gout 0.832, OP 0.787, HTN 0.740, hyperlipidemia 0.736 & thyroid Dz 0.699 https://t.co/1yrlR04z4g https://t.co/c04YtVVERY
Dr. John Cush @RheumNow( View Tweet )
RHEUMATOLOGIST SURVEY ON GOUT - In what percentage of your new Gout patients, do you do arthrocentesis and crystal ID? Answer here: https://t.co/jpebQev4VU
Dr. John Cush @RheumNow( View Tweet )
Gout Imaging in Care
Gout is all about the crystals and the consequences of the disease are due to the inflammation they cause. Getting rid of urate crystals is the ultimate goal in gout, as we now know that it leads to the risk zero of flares and it normalizes the cardiovascular risk level of patients
Read Article
"People wish their enemies dead—but I do not; I say give them the gout, give them the stone!" — Mary Wortley Montagu
Dr. John Cush @RheumNow( View Tweet )
Uric Acid: Is Lower Better?
There is good evidence that a serum urate less than 6 mg/dL is required to meaningfully reduce urate crystal and gout flare burden, but is even lower better and are there any tradeoffs?
https://t.co/W5FsDC5FG0 https://t.co/7mRgkg00uV
Dr. John Cush @RheumNow( View Tweet )
True or False: There is an available antidote for colchicine overdose. Check your answer in this week's RheumIQ at https://t.co/TBlB4pmnKa. https://t.co/RgJ4xEAuZA
Dr. John Cush @RheumNow( View Tweet )
The mortality gap in gout has not improved in 20 years – CV disease is the leading cause of death (2-fold increase).
For more gout content, follow our Gout: More than Flares campaign at https://t.co/xnBVBN5IXZ, https://t.co/c12GmMaatt
Dr. John Cush @RheumNow( View Tweet )
QD Clinic: Cellulitis Paradoxes
Dr. Richard Conway, Dublin, discusses a case of cellulitis and gout. Presented as part of RheumNow's "Gout: More than Flares" campaign during the month of July 2026.
https://t.co/ZeYyISJrrE https://t.co/2Ih4QRa7FK
Dr. John Cush @RheumNow( View Tweet )
FDA Delays Gout Drug NASP with Complete Response Letter
On June 26, 2026, SOBI received a Complete Response Letter (CRL) from the U.S. Food and Drug Administration (FDA) that will delay a decision on NASP, pending the company's answer to questions regarding the drugs https://t.co/NmPbWmYd0p
Dr. John Cush @RheumNow( View Tweet )
Non-gout drugs that may lower uric acid – losartan, amlodipine, ACE inhibitors, fenofibrate, atorvastatin, leflunomide, vitamin C, estrogen, and high-dose ASA.
For more gout content, follow our Gout: More than Flares campaign at https://t.co/xnBVBN5IXZ, https://t.co/vmNvqojAcS
Dr. John Cush @RheumNow( View Tweet )
Problems with treatment adherence in the management of gout
Compared to common medical conditions such as hypertension, type 2 diabetes, hyperlipidemia or osteoporosis, where the reported drug adherence rates are between 50% to 70%, the drug adherence for gout is 37%. This https://t.co/OoLh0HUUH2
Dr. John Cush @RheumNow( View Tweet )
Therapeutic Updates
Watch our 'Systemic Burden of Gout' series as part of this month's Gout More than Flares campaign. Check out our new videos including: Gout & Cardiovascular Disease, Gout & Obesity and Subclinical Inflammation in Intercritical Gout.
Read Post
Recent Blogs
Dr. Jack Cush reviews Gout in this continuing series for Advanced Practice Rheum. Review the companion slide deck here.
Dr. Cush provides a systematic approach to evaluating musculoskeletal and rheumatic complaints in clinical practice.
Read Article
Imagine that 100 years from now, your great granddaughter, an eminent rheumatologist, reviews the history of rheumatoid arthritis mimics.
Read Post
Podcasts
What Lies Beneath - Uric Acid Deposition & Imaging
Gout QD clinics - lessons from the Clinic QD307-QD311
Gout Journal Club
