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Gout

RheumNow Podcast – Upadacitinib Wins in PsA (4.2.2021)

Apr 02, 2021

Dr Jack Cush reviews the news and Journal reports and takes "Back Talk" questions from viewers.

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Inflammatory Conditions Up the Risk of Premature Myocardial Infarction

Mar 31, 2021

The European Journal of Preventive Cardiology reports that younger patients with their first myocardial infarction before age 50 yrs have a higher risk of having a systemic inflammatory disease (SIDs) and higher rates all-cause mortality.



Data derived from the retrospective

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Metanalysis of 32 studies shows most forms of arthritis assoc w/ incr risk of CVA (ischemic stroke: RR=1.53 or hemorrhagic stroke: RR=1.45), esp for RA (RR=1.38), AS (RR=1.49), PsA (RR=1.33), gout (RR=1.4) --risk higher with age <45 years (RR=1.46) https://t.co/YDiebrqtbi

Dr. John Cush @RheumNow( View Tweet )

Mar 31, 2021

Hypertension Unaffected by Urate Lowering Therapy

Mar 30, 2021

Does uric acid contribute to the risk of hypertension (HTN)?  A recent cohort trial shows that allopurinol in young adults does not sufficiently lower blood pressure (BP).



Previous research in a small cohort of obese hypertensive kids showed that urate lowering therapy was assoaciated

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Are You a Super Rheum? https://t.co/omvQXwhcoV https://t.co/8iQaRAi5di
Dr. John Cush @RheumNow( View Tweet )
Mar 26, 2021

RheumNow Podcast – Infection in ANCA-Associated Vasculitis (3.26.2021)

Mar 26, 2021

Dr. Jack Cush reviews the news, FDA Denials and journal articles from the past week on RheumNow.com.




  1. Analysis of CPRD registry and 15,670 MTX treated pts (46,571 PYs) showed discontinuation for abnormal or severely abnormal labs was 42/1000PY and 6/1,000PY and half that

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Dr. Ken Saag giving Rheum Grand Rounds at UT Southwestern. Data showing lower dose colchicine is safer than higher dose in acute gout @UTSWIMchief @KenSaag https://t.co/5KAn9SWlrU
Dr. John Cush @RheumNow( View Tweet )
Mar 25, 2021
News Feature: RECIPE Trial - Mycophenolate to Suppress Immunogenicity with Pegloticase in Gout https://t.co/3TkjwlrSEP https://t.co/GaS8cAJijq
Dr. John Cush @RheumNow( View Tweet )
Mar 24, 2021

RECIPE Trial - Mycophenolate to Suppress Immunogenicity with Pegloticase in Gout

Mar 22, 2021

Pegloticase is indicated in the treatment of severe gout patients but prolonged use may be limited by immunogenicity to the PEG moiety. A randomized, controlled trial has shown that concomitant mycophenolate mofetil (MMF) may prolong the efficacy of pegloticase in gout.

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News Feature: Are You a Super Rheum? https://t.co/LsGpFNXlkp https://t.co/Q9iojEQNqL
Dr. John Cush @RheumNow( View Tweet )
Mar 19, 2021
Top 4 arthritis types that significantly increase the risk of CVA: 1) RA (RR=1.38), 2) ankylosing spondylitis (RR=1.49), 3) psoriatic arthritis (RR=1.33) & gout (RR=1.4). With these, the risk was higher in younger (<45 yrs) (RR = 1.46), not older (>65) https://t.co/Snb6OrtZJH

Dr. John Cush @RheumNow( View Tweet )

Mar 19, 2021
Septic arthritis MIMICs (all presenting as acute monoarthritis) - consider: cellulitis, bursitis, abscess, osteonecrosis, gout, pseudogout, Lyme, Osteomyelitis, reactive arthritis, Lyme disease,, Rheumatoid arthritis, & Transient synovitis (kids) https://t.co/uNirAcoBds

Dr. John Cush @RheumNow( View Tweet )

Mar 15, 2021
Great Gout Teaching points. Here's my 2 cards on how to Stop #Gout https://t.co/bJ4D4Qzd5N https://t.co/ZUX0TXm1Rn
Dr. John Cush @RheumNow( View Tweet )
Mar 14, 2021
News Feature: Weight Loss to Avert Risk of Gout https://t.co/wzf69PvSJc https://t.co/Dph4OAC2Ar
Dr. John Cush @RheumNow( View Tweet )
Mar 05, 2021

RheumNow Podcast – Pounds of Prevention (3.5.2021)

Mar 04, 2021

Dr. Jack Cush reviews and discusses nearly a dozen news reports and journal articles from the past week on RheumNow.com.

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Comparison of MSU crystal ID, DECT scanning and US to Dx gout - study of 147 pts. Compared to the gold standard (MSU ID), Feet/ankles (87% sensitivity; 100% specificity) or knees DECT (91% & 87%) alone had best Dx accuracy. US was inferior to DECT. https://t.co/h8ctkfeadZ

Dr. John Cush @RheumNow( View Tweet )

Mar 04, 2021

Weight Loss to Avert Risk of Gout

Mar 03, 2021

Analysis of the NHANES population survey data shows weight gain during adulthood increases the risk of gout and that maintaining normal weight could reduce the overall gout risk by nearly 33%.



Obesity and gout have long been linked, but the the influence of weight changes during

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News Feature: Combo Therapy Boosts Response in Uncontrolled Gout https://t.co/K6tmYWqDCg https://t.co/Li9fcLnP4f
Dr. John Cush @RheumNow( View Tweet )
Mar 03, 2021

Combo Therapy Boosts Response in Uncontrolled Gout

MedPage Today
Mar 02, 2021

The addition of an immunomodulating agent to pegloticase (Krystexxa) among patients with uncontrolled gout significantly improved response rates, a systematic literature review found.



In a cohort of patients whose gout had been refractory to conventional therapy, co-treatment with

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We are three weeks out from RheumNow Live. Are you planning on attending? https://t.co/vJlU0Z3Q3x

Dr. John Cush @RheumNow( View Tweet )

Feb 26, 2021
News Feature: ANAGO Study - Anakinra for Gout Flare https://t.co/btP7ivMuPO https://t.co/HHsUKsjjuI
Dr. John Cush @RheumNow( View Tweet )
Feb 25, 2021

ANAGO Study - Anakinra for Gout Flare

MedPage Today
Feb 23, 2021

The interleukin (IL)-1 receptor antagonist anakinra (Kineret) was not superior to triamcinolone for relieving gout flares, but had similar effects for pain reduction as the glucocorticoid, a randomized phase II study found.

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SF analysis usually confirms dx, but changes dx 14%. 264 SF samples showed MSU crystals in 89% gout, 9% of CPPD pts. CPP crystals found in 54% of CPPD, 43% of OA & 7% of gout pts. Ca hydroxyapatite seen 1/3 RA, 1/2 OA & 2/3 CPPD https://t.co/B8UkHagXK3 https://t.co/UTncLo6Fyu
Dr. John Cush @RheumNow( View Tweet )
Feb 19, 2021
MIRROR Study: Pegloticase With Methotrexate in Uncontrolled Gout Botson et al has reported that the combination of methotrexate (MTX) and IV pegloticase is safe and effective in patients with uncontrolled gout. https://t.co/DRkIMOAhs4 https://t.co/2dft1QjC6E
Dr. John Cush @RheumNow( View Tweet )
Feb 17, 2021

MIRROR Study: Pegloticase With Methotrexate in Uncontrolled Gout

Feb 15, 2021

Botson et al has reported that the combination of methotrexate (MTX) and IV pegloticase is safe and effective in patients with uncontrolled gout.

This exploratory, open-label clinical trial screened 17 patients and treated 14 patients (all men, 49.3 ± 8.7 years) with IV pegloticase with MTX (15

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