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First Look at COVID-19 Global Rheumatology Alliance Registry

Jun 01, 2020

Gianfresco et al have published the first peer-reviewed analysis of COVID-19 infected, rheumatic disease patients entered into the Rheumatology Global Alliance registry; showing that a) rheumatic disease patient can be infected with COVID-19, b) that DMARD and biologic use has no apparent effect

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RheumNow Podcast - COVID Kids and Men (5.15.20)

May 15, 2020

Dr. Jack Cush reviews the news and journal articles from the past week on

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New ACR Guidelines for Gout Management

May 12, 2020

The ACR has published the 2020 guidelines on the management of gout that includes strong recommendations favoring treat‐to‐target management and starting urate lowering therapy (ULT) for patients with frequent flares, radiographic damage or tophi due to gout.

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RheumNow Podcast – Drive Them Crazy (4.17.20)

Apr 17, 2020

Dr. Jack Cush reviews the news, journal articles and new ACR COVID-19 guidelines from the past week on

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NICE Guidelines on Managing Rheumatologic Conditions During COVID-19 Pandemic

Apr 07, 2020

On April 3rd, the National Institute for Health and Care Excellence (NICE) in the UK, published a rapid guideline for managing children and adults with rheumatological autoimmune, inflammatory and metabolic bone disorders during the COVID-19 pandemic, while protecting staff from infection.

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Global Rheumatology Alliance Registry Will Study COVID-19

Mar 23, 2020

In the midst of a global pandemic of the 2019 Novel coronavirus acute respiratory disease (COVID-19), a small handful of Rheumatologists gathered on social media to collectively grapple with the impact of this virus on vulnerable populations with rheumatic disease.

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Need for Disruptive Innovation in Rheumatology

Mar 05, 2020

A full-read, novel Viewpoint article published in the Annals of Rheumatic Disease (Huizinga TWJ, et al) spotlights a recent international meeting of big thinkers, scientific collaborators and industry dedicated to innovation in rheumatology.

Citing examples of developing disruptive

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Interleukin-37 Targeting in Gout

Mar 02, 2020

The Annals of Rheumatic Disease reports that interleukin- 27 (IL-37) may play an important role in the pathogenesis of gout, paving the way for future therapy with recombinant IL-37 in gouty arthritis.

Activation of the inflammasome by monosodium urate crystals is thought to be

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RheumNow Podcast- Methotrexate Mechanisms (2.28.20)

Feb 28, 2020

Dr Jack Cush Reviews the news and journal articles from the past week on

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Methotrexate and the Risk of Lung Disease

Feb 25, 2020

Rheumatology has a comprehensive overview of methotrexate (MTX) and the risk of lung injury, MTX-related pneumonitis and interstitial lung disease (RA-ILD) with rheumatoid arthritis (RA).  Past reports suggest the frequence of MTX-pneumonitis to be between 0.3 and 11.6%; recent

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Hyperuricemia Predisposes to Coronary Artery Disease in Men

Feb 24, 2020

There are numerous associations between hyperuricemia and cardiovascular disease (CVD). An analysis of the Swedish SCAPIS Pilot study shows that higher levels of serum urate (SU) are associated with an increase in coronary artery calcification score in men but not in women. SU is not associated

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RheumNow Podcast- Half-Empty Flu (2.21.20)

Feb 20, 2020

Dr Jack Cush reviews the news and journal articles from the past week on

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Hypersensitivity Reactions and Gout Tx: Watch the Dose

Feb 11, 2020

Both allopurinol and febuxostat (Uloric) were associated with an increased risk of hypersensitivity reactions among new users of these urate-lowering therapies, a large U.S. study found.

Compared with colchicine, the hazard ratios for hypersensitivity reactions on multivariate analyses

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RheumNow Podcast- 2019 EULAR RA Guidelines (1.31.20)

Jan 31, 2020

Dr. Jack Cush reviews the news and journal articles from the past week on

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NSAID Safety Guidelines

Jan 16, 2020

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for acute or chronic arthritis, headache, visceral pain, postoperative pain, etc but come with a small but significant risk of serious adverse effects, including hypertension, cardiovascular disease, kidney injury and GI

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Diabetics using SGLT2 Inhibitors have a lower Gout Risk

Jan 14, 2020

Researchers from the Brigham and Women's Hospital have reported that adults with type 2 diabetes who were treated with SGLT2 inhibitors had a lower risk of gout compared to GLP1 agonist, suggesting that sodium–glucose cotransporter-2 inhibitors may reduce the risk for gout with type 2 diabetes

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A Role for SGLT2 Inhibition in Gout?

Dec 17, 2019

The antidiabetic medication canagliflozin (Invokana) lowered serum urate and reduced the risk of gout flare in a post-hoc analysis of data from two large clinical trials.

In the CANVAS clinical trial program, which was funded by Janssen Research & Development and included more than

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Predicting Inpatient Gout Flares

Dec 13, 2019

Analysis of New Zealand hospitalized patients revals nine predictors of inpatient flare for people with comorbid gout.

This retrospective cohort study of hospitalised patients with comorbid gout included 625 hospitalised patients, 87 experienced inpatient gout flare.

There were 9

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RheumNow Podcast - The Elusive Hand OA Problem (12.13.19)

Dec 13, 2019

Dr. Jack Cush recaps the news and journal reports from the past week on

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RheumNow Podcast - Monitoring Methotrexate Safety (12-6-19)

Dec 06, 2019

Dr. Jack Cush reviews the news and journal reports from the past week on

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Pegradicase+ImmTOR SEL-212 Shows Promising Results In Active Gout

Nov 25, 2019

Therapies targeting sUA accumulation or improving its excretion are widely used for treatment of symptoms and prevention of progression of gout for decades. Despite our best effort, there is still a significant amount of patients who remain symptomatic and/or experiences progressive

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ACR 2019 - Report From Day 2 (Monday)

Nov 21, 2019

Monday was another full day of sessions and studies here in Atlanta. Following is my roundup of day two.

The Safety of Methotrexate

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PANLAR Ultrasound Study Group: Recommendations On Imaging Modalities In Gout

Nov 20, 2019

Gout is a systemic inflammatory disease with high potential for joint damage due to erosive changes and MSU deposits resulting in disability and chronic pain. Prompt diagnosis and effective treatment are key to better long term outcomes and decreased disability.


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RheumNow Podcast – Better Ways to Treat Gout (11.8.19)

Nov 08, 2019

Dr. Jack Cush reviews the news and journal articles from the past week on

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T2T Lowers Mortality in Gout

Nov 08, 2019

A Spanish prospective cohort of active, uncontrolled gout patients were followed and showed that failure to reach a target serum uric acid (sUA) level of 6 mg/dl (0.36 mmol/L) or less was associated with a 2-3 fold increase in mortality.

Researchers enrolled 1193 gout patients between 

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