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Fibromyalgia/Pain

Gabapentinoid use in COPD pts assoc w/ signif increased risk of severe exacerbation. Compared with nonuse, GABA use incr risk of COPD exacerbation when used for epilepsy (HR 1.58), neuropathic pain (HR 1.35), chronic pain (HR 1.49) https://t.co/EyONh9sASh https://t.co/Sr2FyJQzBj
Dr. John Cush @RheumNow( View Tweet )
Feb 23, 2024
Tonix is developing a drug, TNX-102 SL, that targets poor sleep quality for fibromyalgia. Phase 3 trial in FM (457 pts) showed TNX-102 SL was better (vs PBO) & improved sleep quality (p=0.0000001 & improved daily pain (p=0.00005) https://t.co/QUNdWyNj2l https://t.co/CzD5TEcgTk
Dr. John Cush @RheumNow( View Tweet )
Feb 17, 2024
Greek study finds 251/1264 #RA pts (20%) had difficult to treat RA (D2T). D2T Predictors were Younger age, fibromyalgia, OA, no change in DAS28-ESR in 1st 6mos b/ts-DMARD Rx. Mental-/pain-/metabolic-Dz contributed to LT worsening https://t.co/A5bfth79L2 https://t.co/f5AOvFW9Yu
Dr. John Cush @RheumNow( View Tweet )
Feb 03, 2024
Aging Brain Increases Pain in Older Women https://t.co/450fwH4zQr https://t.co/dttRc4HgYC
Dr. John Cush @RheumNow( View Tweet )
Feb 02, 2024

Aging Brain Increases Pain in Older Women

EurekAlert!
Jan 31, 2024

A new study has found that the brain system enabling us to inhibit our own pain changes with age, and that gender-based differences in those changes may lead females to be more sensitive to moderate pain than males as older adults.

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Outcomes of Acute, Subacute and Persistent Low Back Pain

EurekAlert!
Jan 30, 2024

Low back pain is a major cause of disability around the globe, with more than 570 million people affected. In the United States alone, health care spending on low back pain was $134.5 billion between 1996 and 2016, and costs are increasing.



"The good news is that most episodes of back

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Diet and Osteoarthritis Pain

MedPage Today
Jan 29, 2024

Knee osteoarthritis (OA) pain was worse with a pro-inflammatory diet, an observational study suggested.



Scores on a proprietary "Dietary Inflammatory Index" (DII) were significantly associated with standard knee pain scores among patients over nearly 11 years of follow-up (β=0.21, 95

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This is a crucial nuance. Men and women experience pain differently. The tendency to use that to then dismiss pain in women is entirely incorrect. @lihi_eder @RheumNow #RNL2024 https://t.co/X5QQsaIuNP
Richard Conway @RichardPAConway( View Tweet )
Jan 28, 2024
Is it a lupus flare or a mimic? Fibromyalgia, stress, infection, poor sleep, hypothyroidism, vitamin deficiencies can contribute to pain and fatigue in a patient. – Dr. M Kahlenberg #RNL2024 @rheumnow https://t.co/pLuqyy8gHm
TheDaoIndex @KDAO2011( View Tweet )
Jan 27, 2024
This is the risk. We have to be aware and better at this in order to serve our female patients better @lihi_eder @RheumNow #RNL2024 https://t.co/7JIDtlSGXh
Richard Conway @RichardPAConway( View Tweet )
Jan 27, 2024

Dead Words Eulogy

Jan 26, 2024

The trouble with rheumatology may be the words we live by. Welcome to the eulogy for rheumatology 'dead words'. We're here today to celebrate the loss of rheumatology past. These are dead words in rheumatology, words fortified unfortunately by history and habit. The lexicon of rheumatology is

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2019 NHIS chronic pain study shows signif disparity in nonpharmacologic & integrative medicine (IHM) use by populations. More IHM with city living, higher income & education, widespread pains. Less IHM w/ elderly, males, Blacks, opioid use, depression https://t.co/uoOyQBXTmy https://t.co/yTTVc5zljG
Dr. John Cush @RheumNow( View Tweet )
Jan 24, 2024
Network meta-analyses of 153 trials & 8713 patients w/ chronic pain from TMJ disorders; Most effective (pain & function) were CBT, PT-assisted jaw mobilisation, trigger point injx, jaw exercise/stretching, manipulation, & acupuncture https://t.co/b4kTuWg9QH https://t.co/7SJs0sLtK2
Dr. John Cush @RheumNow( View Tweet )
Jan 19, 2024

Methotrexate Nodulosis (1.19.2024)

Jan 19, 2024

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com. How good (or not) are rheumatologists and what to do about MTX nodulosis?




  1. Network meta-analyses of 153 trials & 8713 patients w/ chronic pain from TMJ disorders; Most effective (pain

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2023 EULAR Non-pharmacological Management of Hip and Knee Osteoarthritis: 2023 update

Jan 16, 2024

EULAR has published the 2023 updated recommendations for the optimal non-pharmacological management of hip and knee osteoarthritis (OA).



Non-pharmacological treatments for OA are as important and impactful at improving pain, function and quality of life in OA. These EULAR

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Sodium Channels, Carbemazepine and Osteoarthritis Progression

Jan 15, 2024

A study published in Nature suggests that therapies affecting sodium channels could be employed to treat osteoarthritis.



Osteoarthritis (OA) affects 528 million people worldwide and yet there are no uniformly effective treatments - other than joint replacement.  The ideal therapeutic

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2023 Rheumatology Year in Review

Jan 10, 2024

Here is my top 10 list (in no particular order) of 2023 advances, game-changers, and developments that changed, or will soon change, rheumatologic practices.

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Black, Asian, and Hispanic Military Members with OA Treated Differently

MedPage Today
Jan 09, 2024

Black, Asian, and Hispanic members of the U.S. Armed Forces were far less likely than their white comrades to undergo knee replacement surgeries after being diagnosed with osteoarthritis (OA), military researchers found.

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Fibromyalgia pain sensitivity may be improved w/ TENS, but may not relate to other pain outcomes. Study of 238 FM pts showed when TENS lower Movt pain ≥30%, there was signif improvement in pressure pain thresholds (P<.001) https://t.co/sZrDUXm1Z6 https://t.co/nRn6uTgv0v https://t.co/LM9Aqmpgps
Dr. John Cush @RheumNow( View Tweet )
Jan 09, 2024

Heritability of Osteoarthritis

Jan 08, 2024

A Swedish study examine the genetic contribution to various rheumatic/musculoskeletal diseases (RMDs) and showed that osteoarthritis (OA) had a large heritability compared with other RMDs.

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QD Clinic - A Non-Textbook Patient Widespread pain and a swollen wrist https://t.co/OixGhsKHRQ https://t.co/lvZ0duYwxw
Dr. John Cush @RheumNow( View Tweet )
Jan 08, 2024
Do I have Arthritis? How I handle this frequent curbside consult question... https://t.co/uX6MUfy59w https://t.co/kYviOhcLQj
Dr. John Cush @RheumNow( View Tweet )
Jan 04, 2024

Curcumin therapy for knee osteoarthritis

Jan 03, 2024

Curcumin is widely used in traditional Chinese medicine to treat arthritis and is presumed to have analgesic and antiinflammatory effects that may benefit those with osteoarthritis, particularly knee osteoarthritis (KOA).



A network metanalysis was performed to gauge the efficacy and

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Sarcopenia Linked to Smoking in Osteoarthritis

Jan 02, 2024

Sarcopenia commonly has been linked to aging and arthritis and contributes significantly to quality of life and outcomes, but the association between sarcopenia and OA has not been well established.



Sarcopenia is an age-linked, skeletal muscle disorder leading to low muscle strength

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Chronic Pain Management tools 1 Medication 2 Physical Therapy 3 Cognitive-Behavioral Therapy 4 Mindfulness Meditation 5 Acupuncture 6 Massage 7 Heat/Cold 8 TENS 9 Yoga/Tai Chi 10 Support groups https://t.co/VBvYR8VK16

Dr. John Cush @RheumNow( View Tweet )

Dec 27, 2023