Fibromyalgia/Pain

#CRISPR reviewed in 👇 #fibroblasts Found deletion of certain genes Ex JIA had marked change in expression Yr in Preview ACR24 @RheumNow @ACRheum Dr Chris Ritchlin 👏 https://t.co/jnmtk1eXGp

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Janet Pope @Janetbirdope( View Tweet )
Difficult to Manage Axial Spondyloarthritis Axial spondyloarthritis (axSpA) is a chronic inflammatory disease primarily affecting the spine and sacroiliac joints, causing back pain, stiffness, and reduced mobility. #ACR24 https://t.co/5i5QtJJm16 https://t.co/c4bllA8ngJ

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Dr. John Cush @RheumNow( View Tweet )
Pts w #osteoarthritis and T2 DM 👇 Who Have ⬆️pain Have worse control of #diabetes Even after adjusting for #BMI Chicken or egg - which comes 1st 🤷‍♀️ #ACR24 @RheumNow @ACRheum Abst#2110 https://t.co/eN2xAw0EMG

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Janet Pope @Janetbirdope( View Tweet )
If your pt with #rheumatoid #arthritis is #exhausted - there is a reason #Meta-analysis of 70000 RA Pts #Insomnia is ⬆️4X vs gen population Due to ▶️#pain ▶️#inflammation ▶️#depression 🤷‍♀️ #ACR24 @RheumNow @ACRheum abst#0480

Janet Pope @Janetbirdope( View Tweet )

Among axSpA patients enrolled in the BE MOBILE 1&2, those who received Bimekizumab achieved ASAS40 response earlier vs PBO Improvements in spinal pain and physical function were significantly reported as early as wk 1 in those who received BKZ vs PBO @RheumNow #ACR24 abs2363 https://t.co/JmcQdURTY4

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sheila @RHEUMarampa( View Tweet )
Harkins @DrTrishHarkins et al. Impact of AC joint OA in PMR. 67% of PMR have AC joint OA. Those who do have worse pain and fatigue scores. @RheumNow #ACR24 Abstr#1974 https://t.co/vAqVuQ5Jzm https://t.co/zx5MMtWdBE

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Richard Conway @RichardPAConway( View Tweet )
Ren et al. XG005, compound with NSAID and neuropathic like effects, in knee OA. At week 4 significant improvements in WOMAC pain, stiffness, function, and primary endpoint of walking pain @RheumNow #ACR24 Abstr#L08 https://t.co/gQDwAmzI4G https://t.co/b22XC7rXnE

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Richard Conway @RichardPAConway( View Tweet )
Cardiology is on! Dr. Olin discusses Fibromuscular Dysplasia findings on imaging Definite: string of beads and/or focal narrowing in right setting / location Possible but nonspecific: dissection, ecstasia, aneurysm, and tortuously @RheumNow #ACR24 https://t.co/Dr81KQfLSf

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Brian Jaros, MD @Dr_Brian_MD( View Tweet )
Non-pharm tx in TAK - not something we always think about but… Impressive effect of resistance exercise!! Not just in symptoms but also inflammatory markers Per Dr. Springer - even a stress ball could be enough for UE vascular health in these pt @RheumNow #ACR24 https://t.co/3O46gobbMX

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Brian Jaros, MD @Dr_Brian_MD( View Tweet )
📢 Late breaking #2002 ➡️In ICI-induced arthritis, patients (n=100) report worsened pain, fatigue, & physical function vs population norms. ➡️High disease activity worsens symptoms #acr24 @RheumNow @jhrheumatology

Caoilfhionn Connolly @CaoilfhionnMD( View Tweet )

I have no doubt many of our RA patients will take GLP-1 agonists in the future. Here's some data @UCLA showing significant differences in not just body weight and HbA1c, but pain. Will be fascinating to see what it does for grumbling disease activity! #ACR24 ABST2259 @RheumNow https://t.co/HdOPACEo3A

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David Liew @drdavidliew( View Tweet )
Active early RA accentuates regional MSK pain. Non-articular pain: easy to ignore & focus on active RA yes, some is related to RA dx activity BUT actually it becomes a bigger issue over time Worth identifying to: clarify what isn't RA Rx appropriately #ACR24 ABST1335 @RheumNow https://t.co/iN5rsyr7Bx

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David Liew @drdavidliew( View Tweet )
bathroom scale

Shedding Weight and Pain: The Promise of Anti-Obesity Medications in RA

Caoilfhionn Marie Connolly, MD

With the advent of FDA-approved anti-obesity medications such as semaglutide and tirzepatide, a new avenue for managing this challenging patient population has emerged. But how might these drugs impact the trajectory of RA, and are we on the cusp of a paradigm shift?

Read Article
Andreasson et al. High intensity interval training provides greater improvements in exercise capacity than standard moderate intensity training in IIM. @RheumNow #ACR24 Abstr#1735 https://t.co/baj7Cq2QjO https://t.co/yiE1vuk2me

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Richard Conway @RichardPAConway( View Tweet )
#1156 @DidemSayginMD et al finds that ~1/3 patients with myositis have comorbid fibromyalgia ➡️Presence of fibromyalgia significantly impacted patient global disease activity #acr24 @RheumNow https://t.co/u1XfqrQU1H

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Caoilfhionn Connolly @CaoilfhionnMD( View Tweet )
Sukumaran et al. Does does of IA steroid matter in knee injection? RCT 30 patients. Triamcinolone. 6-week WOMAC decrease 6% in 10mg, 10% in 20mg , 29% in 40mg @RheumNow #ACR24 Abstr#1186 https://t.co/WUYiEP5dSo

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Richard Conway @RichardPAConway( View Tweet )

It's always so dispiriting to see PMR patients rack up steroid side effects in front of your eyes. (the intense motivation to do better than pred for our PMR patients) #ACR24 @SattuiSEMD @RADoctor ABST0975 @RheumNow https://t.co/FTsvrTIt2F

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David Liew @drdavidliew( View Tweet )
Dietary changes are intermittent fasting are common in axial spondylarthritis (axSpA) patients, possibly reducing inflammation. A study found 55% currently on a diet and 31% fasting. Many believe these practices improve disease activity. Abstr#1459 #diet #axSpA @RheumNow #ACR24

Antoni Chan MD (Prof) @synovialjoints( View Tweet )

Cannabis in Pain: CBD can help with nociceptive pain THC better for neuropathic, centralized pain Perhaps a role in helping decrease other medications like opiates Clauw 16S18 #ACR24 @RheumNow https://t.co/kaQXrD4GAn

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Eric Dein @ericdeinmd( View Tweet )
👴🏼 Ageing & RMDs at #ACR24 🧠 14 factors associated with dementia ❗️Justin Levenson tells us that if we could address all of these, we could reduce dementia risk by 45%! @RheumNow https://t.co/SgC5KMohXy

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Mrinalini Dey @DrMiniDey( View Tweet )
Are you pts using cannabis? In Canada - 20% reported using w/in past 2 years Use for pain, sleep, anxiety 78% noted efficacy Compare to another study said 57% stopped due to inefficacy, 28% AEs - very diff result 70% did not tell their doc 16S18 @BharatKumarMD #ACR24 @RheumNow https://t.co/6NAECW5MJK

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Eric Dein @ericdeinmd( View Tweet )
Cannabis and Physical Function Very small effects on meta-analysis PO cannabis - 4% benefit (0.1-8%) of achieving at least MID of SF36 function scale 16S18 @BharatKumarMD #ACR24 @RheumNow https://t.co/qQOYt1m3ub

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Eric Dein @ericdeinmd( View Tweet )
IV or inhaled THC: Works quickly with high peak, feel euphoric but not sustained response Oral is much better for medicinal usage @RheumNow #ACR24 https://t.co/3PatgEFjZh https://t.co/wrrLMpfL5D

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Eric Dein @ericdeinmd( View Tweet )
Clauw: think of THC and CBD as “completely different” Cannabidiol - safe, not psychoactive, “can use liberally” THC - psychoactive with effects on CB1 and CB2 receptors. CB1 affects the brain where CB2 is more in inflammation #ACR24 @RheumNow https://t.co/A0TgSpAO64

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Eric Dein @ericdeinmd( View Tweet )
Happening now: 16S18 Into the Weeds: Cannabis in Rheum @EleniTiniakou @BharatKumarMD Do you discuss marijuana with your patients? @RheumNow #ACR24

Eric Dein @ericdeinmd( View Tweet )

Recent Blogs

From the Archives: Rheumatology Dead Word Cemetery

Jack Cush, MD
CTD.jpg
I recently heard of a secondary school assignment wherein students were challenged to “bury” a word that was no longer useful or appropriate. Their exercise has now evolved into an unofficial RheumNow task force to retire diagnostic terms that have grown into misuse in rheumatology and medicine. How did we decide which words should perish? And by what criteria? Who has the final say? Read Post

Pain in Psoriatic Arthritis

Philip Mease, MD
backpain.hip_.jpg (keep)
Pain is typically ranked by both patients and physicians as the most important symptom of psoriatic arthritis (PsA) to assess and treat. Although the predominant concept of the etiology of pain in PsA is that of inflammation in peripheral joints, entheses, and bone signaling through peripheral nociceptive fibers, perceived as pain in the central nervous system, it is actually more complex than that. The ability of a treatment to ameliorate pain is one of the principle measures of its effectiveness. Thus pain improvement or worsening are key determinants of shared decision making about treatment in PsA.  Read Post

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