3-year, RCT of Mediteranean diet vs usual care in 924 older adults w/ metabolic syndrome & BMI > 27. Med. diet shows signif wt loss (3.4% vs 0.4%), w/ improved BMD (by DEXA) at year 3, especially in women. https://t.co/mllx6l1QnM https://t.co/I5e8PXX2oX
Dr. John Cush @RheumNow( View Tweet )
A brief history of familial Mediterranean fever - FMF is most common periodic fever syndr. an inherited polyserositis mainly affects Arabs, Armenians, Jews, & Turks. Hx may date back to 1802 & Heberden. Osler described 11 cases in 1895. 1st clear report 1945 by Siegal 10 pts. https://t.co/m20uO3bOoj
Dr. John Cush @RheumNow( View Tweet )
Lessons Learned from a Lupus Registry: Two sides of one coin?
It's Dr. Janet Pope reporting at RheumNow on our special lupus edition. I'd like to talk about lessons learned from a Canadian lupus registry. Is it two sides of one coin?
https://t.co/IxMZhA1uht https://t.co/PJixCj8d6g
Dr. John Cush @RheumNow( View Tweet )
CDC: U.S. Overdose Deaths Decrease Almost 27% in 2024, dropping from 110,037 deaths (2023) to ~80,391(2024). Despite these improvements, overdose remains the leading cause of death for Americans aged 18 to 44. https://t.co/UXTaOPf3P7 https://t.co/1NQUfoZ1eK
Links:
Dr. John Cush @RheumNow( View Tweet )
Is the nosology of CPPD outdated? Pseudogout to chondrocalcinosis? In 2011 EULAR taskforce rec the preferred term "calcium pyrophosphate deposition dz". G-CAN aims to update & standardised terminology for CPPD, requiring change to ICD-10 & adoption by societies https://t.co/mdqwDQN1po
Dr. John Cush @RheumNow( View Tweet )
#2 most downloaded paper in 2024 on Journal of Clinical Medicine was “IgA Vasculitis (Henoch–Schönlein Purpura): An Update on Treatment” - Steroids are 1st line Rx, esp in adults w/ severe IgAV; other Rx include calcineurin inhibitors, MMF, RTX , https://t.co/F5jogxkoGr
Dr. John Cush @RheumNow( View Tweet )
Full read overview of Discoid Lupus. https://t.co/G6lXWTRSFn https://t.co/yjVsDg0D5d
Links:
Dr. John Cush @RheumNow( View Tweet )
Is the nosology of CPPD outdated? Pseudogout to chondrocalcinosis? In 2011 EULAR taskforce rec the preferred term "calcium pyrophosphate deposition dz". G-CAN aims to update & standardised terminology for CPPD, requiring change to ICD-10 & adoption by societies https://t.co/wTdc0Tosc6
Dr. John Cush @RheumNow( View Tweet )
Soluble CD13 (sCD13) has pro-inflammatory effects & is elevated in severe COVID-19. sCD13 is chemotactic, angiogenic, & arthritogenic. In COVID-19, sCD13 was assoc w/ sCD13 severity, ethnicity, inflammation markers, NETosis, & vascular injury/thrombosis. https://t.co/dTT9X49DIt
Dr. John Cush @RheumNow( View Tweet )
Full read overview of Discoid Lupus. https://t.co/aXgveR2NwF https://t.co/9JK6CNqedO
Links:
Dr. John Cush @RheumNow( View Tweet )
Risk Factors for Knee Osteoarthritis
New research from the University of Sydney reveals that obesity, having a knee injury and occupational risks such as shift work and lifting heavy loads are primary causes of knee osteoarthritis.
https://t.co/Kc686Zc8Xa https://t.co/PtyLU6jBkp
Dr. John Cush @RheumNow( View Tweet )
Tuesday Night Rheumatology: 🔓 Lupus Unlocked: Cutaneous SLE
Join us for a discussion of the diagnosis, management, and latest insights into cutaneous manifestations of SLE.
Featuring:
Dr. Victoria P. Werth
Dr. Matilda Nicholas
Dr. Anthony Fernandez
Dr. Christopher Richardson https://t.co/UNazbo9TuZ
Dr. John Cush @RheumNow( View Tweet )
D-Lay Trial: High-Dose Vitamin D Retards Multiple Sclerosis
A randomized clinical trial with oral high-dose cholecalciferol ( vitamin D3) was shown to prevent or delay the onset of clinically isolated syndrome (CIS), typical for multiple sclerosis (MS). https://t.co/ZcO5wt33Z0
Dr. John Cush @RheumNow( View Tweet )
More Women with Autoimmune Diseases Die from Cardiovascular Disease
Women with the autoimmune diseases rheumatoid arthritis, lupus or systemic sclerosis may have a higher rate of death related to cardiovascular disease than men with the autoimmune diseases, according to new https://t.co/Px9ayANsFL
Dr. John Cush @RheumNow( View Tweet )
Pitfalls in sacroiliitis imaging: Bone marrow edema may also be seen in young-middle-aged postpartum women, & athletes & kids (ongoing bone growth) & w/ advancing age (DJD) https://t.co/bwS047wlmI https://t.co/pqI3xTYtCz
Dr. John Cush @RheumNow( View Tweet )
Lupus QD Clinic - Polar Opposite Approaches for Lupus
Dr. Eric Dein, Summit, New Jersey, presents SLE QD Clinic: Polar Opposite Approaches for Lupus.
https://t.co/sGcYmo8gWs https://t.co/3hrYC6ATBy
Dr. John Cush @RheumNow( View Tweet )
International Myositis Assessment and Clinical Studies Group (IMACS) reached a consensus on ‘anti-synthetase syndrome’ as the preferred nomenclature and "ASyS" as the preferred abbreviation for the ‘anti-synthetase syndrome. https://t.co/TuTzVVZzZO https://t.co/qs5f1qATKi
Dr. John Cush @RheumNow( View Tweet )
Using 16S rRNA gene amplification, Gut bacterial taxa from 53 CRPS pts compared to 52 controls. Differences were seen in microbiome and plasma short-chain fatty acid levels between CRPS patients and controls, w/ >90% accuracy https://t.co/TO7CCmmtD5 https://t.co/Gn9loJPNfM
Dr. John Cush @RheumNow( View Tweet )
Finish Birth Cohort followed since 1986, who were asymptomatic, found abnormal MRI knee findings, esp cartilage defects in the patellofemoral (56%) & tibiofemoral joints (25%) joints. Small/doubtful patellofemoral (52%) & tibiofemoral (17%) osteophytes seen. Most w/ High BMI. https://t.co/nQKREE4XfU
Dr. John Cush @RheumNow( View Tweet )
Congrats to Dr. Virginia Pascual who was elected to American Academy of Arts and Sciences. Virginia isthe director of Gale & Ira Drukier Institute for Children’s Health & Ronay Menschel Professor of Pediatrics @ Weill Cornell Medicine. Her translational/basic research have been https://t.co/hOYi59xMC5
Dr. John Cush @RheumNow( View Tweet )
Pitfalls in sacroiliitis imaging: Bone marrow edema may also be seen in young-middle-aged postpartum women, & athletes & kids (ongoing bone growth) & w/ advancing age (DJD) https://t.co/bwS047wlmI https://t.co/FvWlEcZ5JP
Dr. John Cush @RheumNow( View Tweet )
Using 16S rRNA gene amplification, Gut bacterial taxa from 53 CRPS pts compared to 52 controls. Differences were seen in microbiome and plasma short-chain fatty acid levels between CRPS patients and controls, w/ >90% accuracy https://t.co/TO7CCmmtD5 https://t.co/zM1wKxjGBX
Dr. John Cush @RheumNow( View Tweet )
Finish Birth Cohort followed since 1986, who were asymptomatic, found abnormal MRI knee findings, esp cartilage defects in the patellofemoral (56%) & tibiofemoral joints (25%) joints. Small/doubtful patellofemoral (52%) & tibiofemoral (17%) osteophytes seen. Most w/ High BMI. https://t.co/LHqmRHM5wF
Dr. John Cush @RheumNow( View Tweet )
FDA has approved nipocalimab (Imaavytm), a FcRn for use in generalized myasthenia gravis (gMG). It is approved for using in gMG patents who are anti-AChR and anti-MuSK antibody positive adults and pediatric gMG patients aged 12 and older. https://t.co/fYCWuTZ6Uz https://t.co/aSfydBS9xh
Dr. John Cush @RheumNow( View Tweet )
D-Lay MS trial: DBRPCT of Oral cholecalciferol 100 000 IU q2wks x 24 mos.signif reduced Dz activity in clinically isolated syndr(CIS) & early relapsing-remitting MS typical for MS. Dz activity seen in 60% w/ Vit D vs 74% w/ PBO (HR 0.66). Also time to Dz activity (432 vs 224d; https://t.co/GQsnnuWS9R
Dr. John Cush @RheumNow( View Tweet )
Recent Blogs
How would you manage a patient with Overlap (anti-synthetase) syndrome, ILD, polyarthritis and myositis?
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