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Relapsing polychondritis (RP) has always struck me as a condition with highly variable implications - and this cluster analysis from the @NIH_NIAMS prospective cohort agrees. There's RP, and then there's RP!
@maferradastrong @petercgrayson et al #ACR19 ABST1719 @RheumNow https://t.co/mbfbTxwc6U
David Liew drdavidliew ( View Tweet)
RCT Tildrakizumab (IL23i) in Psoriatic Arthritis
Beat PLBO for ACR20 (NNT~4), ACR50 (NNT~4), and pt global (NNT~3 for 50% improvement)
Very well tolerated (NNH>50, any adverse event)
Exciting new tx! Need comparison RCT vs TNF/IL17i
@RheumNow #acrbest #ACR19 Abst#1821 https://t.co/QFQEA8L3sY
Mike Putman EBRheum ( View Tweet)
#ACR19 @rheumnow ABS 1237 OLT1177, oral NLRP3 inflammasome inhibitor- a potential drug for Rx of gout flares: ⬇️ systemic inflamm by ⬇️ WBC count & circulating IL-1β& IL-6 in all3 doses (2000mg, 1000mg or 300mg). ⬇️ ex vivo IL-1β & IL-6 production by cultured PBMCs days 3, 7& 14
Olga Petryna DrPetryna ( View Tweet)
#ACR19 @rheumnow abs1353 Observational SMART-RA trial concludes smart phone app based RA management improves DAS28 (p < 0.05), ESR (p≤0.05), CRP (p≤0.05) and HAQ-DI (p≤0.5) after 1y of use, suggesting smart phone technology improves quality of life & disease control in RA https://t.co/rERu2oF2VT
Olga Petryna DrPetryna ( View Tweet)
Abstr#1759: 64 pts randomized to either MTX 10mg or PBO. Evolution of pain b/w 2 groups no different. Function no different. Dose too low? PBO effect? Structural evolution modified by MTX. Is that our goal? #ACR19 @RheumNow #OA #osteoarthritis
Maeve Gamble MaeveGamble ( View Tweet)
#Rheumatology is the best field in medicine!
#RheumatologyMeme #ACR19 @ACRheum https://t.co/SmxjmTbV0j
Adam Kilian MD KilianMD ( View Tweet)
PATCH study: HCQ 400mg started by wk 10 gestation significantly reduces the recurrence of CHB below the historical rate of 18% to 7.4%. #ACR19 @RheumNow
Maeve Gamble MaeveGamble ( View Tweet)
IFX detected in stool a/w higher CRP and active bowel disease.
An inflamed bowel can change the pharmacodynamics of some of the therapies we use. Low albumin may indicate leaky gut. #ACR19 @RheumNow #IBD #AS #ankylosingspondylitis https://t.co/1BTU0guOC1
Maeve Gamble MaeveGamble ( View Tweet)
Choosing the right medication matters, but choosing the wrong medication also matters - Dr. Edward Behrens
#ACR19 @RheumNow
Kanika Monga, MD DrKanikaMonga ( View Tweet)
Higher risk patients – Antimalarial Retinal Toxicity
- Concomitant tamoxifen (increase risk 5-fold)
- GFR <50 cc/min
- Dose >5 mg/kg
#ACR19 @RheumNow
Kanika Monga, MD DrKanikaMonga ( View Tweet)
Urate lowering therapy indications for #Gout:
- Tophi
- Frequent flares ( ≥ 2/yr)
- Chronic kidney disease
- Hx of renal stones
Will these change in the 2019 guidelines?
#ACR19 @RheumNow
Kanika Monga, MD DrKanikaMonga ( View Tweet)
🤳My first ever selfie video series -- I ask the experts for some twitter advice! Come tag along with me :)
#ACR19 @RheumNow @ACRheum @UTHealth
Kanika Monga, MD DrKanikaMonga ( View Tweet)
Retrospective review of 236 RA pts and 166 pts w/other systemic diseases who received Shingrix: no significant increase risk in disease flare or vaccine-related AEs. Abstr#1804 #ACR19 #whyivaccinate @RheumNow @LCalabreseDO @BetsyKirch
Cassandra Calabrese CCalabreseDO ( View Tweet)
Abstr#1802 - nice study from @CleClinicMD confirming low clinical value of annual quantiferon screening for LTBI in the absence of new or ongoing risk factor #ACR2019 @RheumNow @ElaineHusniMD #cleclinicrheum
Cassandra Calabrese CCalabreseDO ( View Tweet)
Abstr#1806: Another centre’s experience with IA-irAEs from ICIs #ACR19 @RheumNow https://t.co/OFZaYqMSFR
Maeve Gamble MaeveGamble ( View Tweet)
Don’t forget to check immunoglobulins prior to starting Rituximab! Thanks for sharing our results! @hausmannMD #ACR19 @RheumNow https://t.co/PNGe72waez
Stefanie D Wade, MD doctorswade ( View Tweet)
Beware hydralazine! Associated vasculitis with high frequency of CKD and poor outcomes. 100%renal involvement and ANCA positivity! Abstr#1667 @SajaAlmaaitah @kinanah9 @CleClinicMD #cleclinicrheum #ACR19 @RheumNow https://t.co/qJM49xN6Rx
Cassandra Calabrese CCalabreseDO ( View Tweet)
Abstr#824 VERVE results - safety of live heroes zoster vaccine in pts on TNFi- no cases of vaccine-related varicella @LCalabreseDO @BetsyKirch @RheumNow #ACR19 #cleclinicrheum https://t.co/zPDvQujgzP
Cassandra Calabrese CCalabreseDO ( View Tweet)
Excellent irAE summary by Ryan Sullivan -judicious use of steroids, High doses when needed, low dose when possible. Pre-existing AID not a contradiction to checkpoint inhibitor Tx! @RheumNow @LCalabreseDO @cappelliMD @lexmeara #ACR19 #cleclinicrheum https://t.co/TOTXQzxXhp
Cassandra Calabrese CCalabreseDO ( View Tweet)
Do you co-manage your PsO/PsA patients with dermatology? #ACR19 @RheumNow
Dr. Rachel Tate uptoTate ( View Tweet)