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Meloxicam Superior to Placebo and Cognitive Behavioral Therapy in Knee OA

d Jack Cush, MD

Pain management in knee osteoarthritis (OA) is confounded by studies showing less is equal to usual standards of care. A recent trial showed that meloxicam was superior to placebo or cognitive behavioral therap (CBT); although the differences were small. 

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covid.corona

Characteristics Underlying Mortal COVID-19 Outcomes

d Jack Cush, MD

From January 1, 2020–May 18, 2020, approximately 1.3 million cases of coronavirus disease 2019 (COVID-19) and 83,000 COVID-19–associated deaths were reported in the United States.

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FINAL 2020 Podcast Graphic

RheumNow Podcast – LTF – Listen to Fauci (7.17.20)

d Jack Cush, MD

Dr. Jack Cush reviews the news, tweets and journal articles from the past week on RheumNow. Let's dig into this week's 14 highlights.

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PRIME Cells Predicting Rheumatoid Arthritis Flares

d Jack Cush, MD

The current issue of NEJM reports a novel cell type that may be used to identify rheumatoid arthritis (RA) patients who may flare. 

Investigators prospectively collected blood samples from 4 patients for longitudinal RNA sequencing (RNA-seq) for discovery of moleculartranscripts that were differentially expressed before flares.

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HCQ May Help Prevent Fetal Heart Block

d RheumNow

Hydroxychloroquine (HCQ) helped reduce recurrent maternal autoantibody-mediated congenital heart block (CHB) in fetuses, an open-label study suggested.

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Single center retrospective Korean study of 1280 Ankylosing Spondylitis patients (595 exposed to TNFi) showed that TNFi was associated with significantly decreased Xray change rate (mSASSS) (β=−0.112, p=0.004). https://t.co/W4j0Ckt0R2

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Dr. John Cush RheumNow ( View Tweet)

Genotyping and microbiota data TwinsUK study (excluding RA) shows that Prevotella spp were positively assoc with RA risk; further validated by first-degree relatives of RA patients where Prevotella was assoc w/ HLA-DRB1 & preclinical arthritis. https://t.co/7i2NNi7iip

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Dr. John Cush RheumNow ( View Tweet)

Bisphosphonate therapy may be protective against radiographic knee OA progression in early‐stage patients (KL grade < 2) (HR 0.53), especially non-obese. Study from 1977 women in the Osteoarthritis Initiative. https://t.co/tZhovfMWTh

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Dr. John Cush RheumNow ( View Tweet)

A randomized controlled trial testing dexamethasone for Covid-19 (the RECOVERY trial) showed that, compared with usual care, this corticosteroid drug reduced 28-day mortality in hospitalized patients. #COVID19 #SARSCoV2

NEJM NEJM ( View Tweet)

#Texas we REALLY need to #WearAMaskSaveALife ... 6 patients of mine have tested positive for #COVID19 in the last week. #MedTwitter @rheum_covid @COVID19Tracking

Mohammad A. Ursani MD, RhMSUS DrMAUrsani ( View Tweet)

#LTF https://t.co/Knfc84QKjG

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Dr. John Cush RheumNow ( View Tweet)

#Fauci https://t.co/Brmp85KqTt

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Jeff Sparks jeffsparks ( View Tweet)

RheumNow Podcast is Up! Listen to Fauci! Watch it here>> https://t.co/dHq3fP85Ip or Listen to the Podcast>> https://t.co/LdHO7fKUCp

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Dr. John Cush RheumNow ( View Tweet)

Registry of COVID CNS complications reports 125 pts; 77 (62%) w/ Cerbrovascular event (57 ischemic CVA), 9 intracerebral hemorrhage, 1 CNS vasculitis. 39 w/ AMS, 9 encephalopathy & 7 encephalitis. 10 new-onset psychosis, 6 dementia, 4 affective Dz https://t.co/mXyTHIFBIE

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Dr. John Cush RheumNow ( View Tweet)

MMWR reports 2019 survey data showing 6.6% of women used opioid during pregnancy. 21% admitted misuse, 27% wanted to stop/reduce narcotic use and 32% did not receive MD counseling about how opioid use could affect an infant. https://t.co/Ybrjv4Anmk

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Dr. John Cush RheumNow ( View Tweet)

Regeneron/Sanofi have reported their US phase 3 trial of Kevzara (sarilumab) 400 mg given to 194 critically ill COVID-19 patients, requiring mechanical ventilation, did not meet its primary and key secondary endpoints when added to supportive care. https://t.co/UPfGJKWEM9

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Dr. John Cush RheumNow ( View Tweet)

Retrospective study of 603 myositis (IIM), 4047 RA and 4061 controls shows IIM has higher risk of CV events (HR 1.38) and MI [HR 1.61] but not CVA [HR 0.92]. The CV risk in IIM was equal to that in RA [HR 1.01]. IIM CV risk only present 1st 5 years https://t.co/EyD3GHv2YY

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Dr. John Cush RheumNow ( View Tweet)

Systematic review of DYSPHAGIA in inflammatory myositis finds it may be an initial or sole symptom. Prevalence in IIM was 36% and higher 56% inclusion body myositis, cancer or NXP2 -associated myositis. Dysphagia may be complicated by aspiration pneumonia https://t.co/wDg3tWaooP

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Dr. John Cush RheumNow ( View Tweet)

Listen to Fauci #LTF !!

Dr. John Cush RheumNow ( View Tweet)

The preliminary #ACR20 schedule is here! Along with all your favorite plenary and networking sessions, the program will feature #Rheumatologist Dr. Anthony Fauci giving us a live update on #COVID19. @ACRheum #ACRConvergence - Where Rheumatology Meets https://t.co/IWbiVw9PSP

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Victoria Shanmugam VickiShanmugam ( View Tweet)

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