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RheumNow Podcast – Upadacitinib FDA Approved for RA (8.23.19)

d Jack Cush, MD

Dr. Jack Cush reports on the news and journal reports from the past week on RheumNow.com, including: how your genetics may shape your microbiome; GERD as a risk factor for TMJ?; how can MDA-5+ dermatomyositis be any worse; new drug happenings; StillsNow.com; and more.

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A Multidimensional Definition of Remission

d Jack Cush, MD

A study from Leeds suggests 'multi-dimensional remission' (MDR) can be seen in one-third of RA patients achieving DAS28-remission; such patients have better patient-reported outcome measures, making it an optimal goal, especially from a patient's perspective.

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Osteoporosis Tx: Good for Bones, but Not for Cutting Death Risk

d RheumNow

Osteoporosis treatments were not linked with reduced overall mortality, according to a meta-analysis of placebo-controlled trial data.

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Good Pregnancy Outcomes for DMARD Exposed JIA Patients

d Jack Cush, MD

A study of pregnancy outcomes in 98 women with juvenile idiopathic arthritis (JIA) who were exposed to DMARDs shows no increased risk of major adverse pregnancy outcomes.

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FDA has approved Taltz (ixekizumab) use in Active Ankylosing Spondylitis (Axial Spondyloarthritis). IXE previously approved for psoriasis & PsA. Recommended dose is 160 mg SC (two 80 mg injections) at Week 0, followed by 80 mg every 4 weeks. https://t.co/S8zwuYuK2H

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Dr. John Cush RheumNow ( View Tweet)

CLE deserves a specialty approach, with more education and people (derms & Rheums) dedicated to it's managemment https://t.co/VDH4ksDRW4

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Dr. John Cush RheumNow ( View Tweet)

@ClinRheumatol Whoa...this an 11 patient uncontrolled report - not a study and certainly NOT evidence that abatacept works in Sjogrens. ABA is not included in guidelines for, and not approved for use in Sjogrens. Journals who promote$$$ their publications should not be interpreting results!

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PBMs: Driving Up Costs and Lowering Quality Care in America https://t.co/4gQr9L5Ate

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ATAP ATAPAdvocates ( View Tweet)

European Study of 24,195 axSpA pts shows that 1st TNFi resulted in 27% ASDAS inactive disease @6 months & 59% achieved BASDAI <40; 80% continued Rx after 1 year. 1178 patients w/ non-radiographic axSpA had lower 12-mos retention (73%) https://t.co/KJn5eD6wWw

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Dr. John Cush RheumNow ( View Tweet)

RheumNow Podcast is up! Upadacitinib Approved, ULT prevents erosions, JIA pregnancies, MDA-5 outcomes & more. Watch it here>> https://t.co/kzu32MMmRL or listen to the PODCAST on iTunes or SoundCloud>> https://t.co/Ewi3Kc6lta

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Dr. John Cush RheumNow ( View Tweet)

https://t.co/Es3nquURHJ is my new website for Physicians and Patients interested in Still’s disease (systemic juvenile idiopathic arthritis), periodic fever syndromes and autoinflammatory diseases. Check out the cool AOSD Diagnosis Calculator!

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Day 2 of the NIH Symposium on Autoinflammatory and immune-dysregulatory Diseases - 90 World experts on IL-1 mediated autoinflammatory diseases, autoinflammatory Type-I interferonopathies, MAS/HLH, LIVE STREAMING here>> https://t.co/WQjtS1JJue

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RCT of 139 knee OA pts given either curcumin 500-mg tid or diclofenac 50-mg bid. At days 14 and 28 both had similar improvement in pain and KOOS score; but curcumin had better tolerance, less GI sxs and H2 blocker use. https://t.co/tcsDQWQOMg

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Retrospective review of US-guided Synovial Biopsies performed (clinical practice n=52, research n=12) - syn tissue obtained in 88%. Utility/impact was good (37% Dx impact, >95% PPV or NPV for infection & research 92% success. https://t.co/A7vzIHnKH1

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Study of 1272 RA pts, 69.5% were seropositive. Seropositive RA patients had two-fold increased risk for abnormalities on PFTs (ORs ranging from 2.48 RLD, 3.12 COPD & 2.30 DLCO abnl; associations were stronger for RF+ than for CCP+. https://t.co/RQ5GgoGqwA

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Dr. John Cush RheumNow ( View Tweet)

Thurs 8AM - start of the 2nd NIH Symposium on Autoinflammatory and immune-dysregulatory Diseases - World experts on IL-1 mediated autoinflammatory diseases, autoinflammatory Type-I interferonopathies, MAS/HLH, LIVE STREAMING AT 8AM EST https://t.co/XJ4EOIXyYm

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Retrospective review of temporal artery biopsies from Johns Hopkins Wilmer Eye institute from 2007-17 shows the adjusted incidence rate of Bx+ GCA was 3.1 (1.0-5.2) in blacks and 3.6 ( 2.5-4.7) per 100 000 white patients; higher in women (1.9x vs Men) https://t.co/MeO9cBqovg

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CMAJ reports on a case controlled study of >3000 pts shows GERD to be a a risk factor for TMJ disorders (OR 2.74; 1.88 to 3.98) with such patients having a higher rates of somatization, anxiety and sleep disorders. https://t.co/jrTPCOVouI

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Analysis of 128 Pediatric Rheum pts (JIA, FMF, etc) analzyed for reactions to 8 different biologics during 32,494 infusions/injections - the frequency of anaphylaxis (from TCZ or RTX) was 3.9% in children. https://t.co/GzvcR0R7Bv

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Telemedicine study of 122 #RA patients in the Alaska Tribal Health System shows that video telemedicine was more in pts with higher disease activity, positive views of telemedicine, and whose physicians used telemedicine more often. https://t.co/Y95ihyfSs8

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