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Understanding Non-arthritic Rheumatic iRAEs

d David Liew, FRACP

A better understanding of rheumatic immune-related adverse event phenotypes beyond inflammatory arthritis has been furthered by work from three abstracts presented at EULAR 2019 in Madrid.

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Blinded by the Use of Antimalarials in Lupus?

d Janet Pope, MD, MPH, FRCPC

Hydroxychloroquine (HCQ) will decrease SLE flares improve lipids, decrease clots, improve survival, augment the response to mycophenolate and are the cornerstone of treatment as per the SLE EULAR guidelines presented at EULAR 2019 in Madrid and also published in ARD.

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#eular2019 H2H abatacept vs adalimumab prev study “AMPLE” showed similar efficacy (single blinded RA <2y study). Now “Early AMPLE” study for seropositive RA with or without HLA shared epitope confirmed previous observation of superiority of ABA at 24w

Alberta Hoi tuna0sashimi ( View Tweet)

https://t.co/Mv1P5Gk71G

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Mehreen MehreenUoM ( View Tweet)

It is always an absolute privilege working with Iain Looking forward to his stint as @eular_org President...his track record suggests there will be some innovations ahead! @Racegbn @iiiglasgow @UofGMVLS @imidbio https://t.co/932Iz9kayV

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Stefan Siebert StefanSiebert1 ( View Tweet)

EULAR HIGHLIGHTS. Ixekizumab beats adalimumab in PsA on combined end pt of skin + joints due to high skin response #EULAR2019 @RheumNow

Janet Pope Janetbirdope ( View Tweet)

EULAR Highlights. 2 new JAKs presented more RA data. Upadacitinib and Filgotinib. Safety of JAKs in meta-analysis -no new safety signals. Tofacitinib use in Corrona = TNFI except slightly more shingles. 7yr Baricitinib data good - no VTE in LTE #EULAR2019 @RheumNow

Janet Pope Janetbirdope ( View Tweet)

Eular highlights. RA guidelines still mostly like before - all MOA drugs ok after MTX and still taper if sustained remission. I think don't fully D/C all background Rx in most #EULAR2019 @RheumNow

Janet Pope Janetbirdope ( View Tweet)

Eular highlights. Don't forget aerobic supervised exercise to be prescribed in Axial SpA #EULAR2019 @RheumNow

Janet Pope Janetbirdope ( View Tweet)

Comparison of high and low iris acid levels in a large cohort of gout patients shows high SUA associated with more comorbidities and CKD, more colchicine & indocin use. #EULAR2019 SAT0435 https://t.co/FvUU4Q6Ky9
Dr. John Cush RheumNow ( View Tweet)
Dr. Peter Lipsky - 1 Million #Gout Patients & who cares for them. SAT0435 #EULAR2018 https://t.co/WfFR4tRf2p

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Dr. John Cush RheumNow ( View Tweet)

A very productive Mentor Mentee meeting with the best mentors and best mentees @EMEUNET #EULAR19 #Madrid https://t.co/nLQkdnK0u3
EMEUNET EMEUNET ( View Tweet)
@drdavidliew @OrphaLung @TobyMMaher @RheumNow See @RheumILD! We love Ritux!

Isabelle Amigues, MD, MS, RhMSUS, human, mom etc isa75012 ( View Tweet)

Eular highlights? SSc trials near misses for efficacy. Abatacept v placebo in early diffuse scleroderma had begun primary outcome for skin but positive composite measure of response (CRISS) TCZ beg on skin but nearly significant; maybe less lung progression #EULAR2019 @RheumNow

Janet Pope Janetbirdope ( View Tweet)

Eular highlights SLE Rx Belimumab in largest SLE RCT is safe. Ustikinumab decreases interferon in SLE- Eploratory results from + RCT. Maybe blood levels of hydroxychloroquine may reduce Retinopathy by decreasing dose if high and detect adherence if too low #EULAR2019 @RheumNow

Janet Pope Janetbirdope ( View Tweet)

Eular highlights in scleroderma. Nintedanib + for SSc ILD. Positive correlations of combined response in SSc measure and PROs in RCT exploratory analysis of Lenabusum a cannabinoid receptor agonist, maybe riociguat helps Raynauds and digital ulcers #EULAR2019 @RheumNow

Janet Pope Janetbirdope ( View Tweet)

Eular highlights Sjögren's syndrome. Maybe new Rx pathway of small early phase RCT with RSLV-132 via toll like receptor 8 acting on interferon - reducing fatigue. Too early to know. #EULAR2019 @RheumNow

Janet Pope Janetbirdope ( View Tweet)

Benefits of #physicalactivity in #rheumatoidarthritis ➡️Disease related outcomes ➡️Systemic outcomes ➡️Financial costs via @NoreleeK #EULAR2019 #Exercise #arthritis https://t.co/5vnKaPdAQB
Dr Ai Lyn Tan DrAiLynTan ( View Tweet)
Here's a 2 min snapshot of #physicalactivity uptake at #EULAR2019 ➡️88% (23) used #escalator ➡️12% (3) used #stairs ➡️87% (20) on escalator stood still ➡️13% (3) walked on escalator Well done all who used stairs!👍🏽 Good use of facilities & opportunities https://t.co/7NgdOBtc1z
Dr Ai Lyn Tan DrAiLynTan ( View Tweet)
RheumNow Podcast from EULAR19 is up! EULAR 2019 Streamin' (6.14.19). You can view it here>> https://t.co/fTdH4kuCJX or listen on iTunes or SoundCloud >> https://t.co/TGxUixKoIj

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Dr. John Cush RheumNow ( View Tweet)

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