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Main factors influencing #physicalactivity in inflammatory #arthritis patients are psychological
➡️Main factor related to knowledge of benefits of #exercise & symptoms
➡️Modifiable
➡️Health professional support key
FRI0642-HPR #EULAR2020
👉🏽https://t.co/Vdc7rjnC6Y
by @DavergneT https://t.co/aMUHA5IMrn
Dr Ai Lyn Tan DrAiLynTan ( View Tweet)
@Janetbirdope @eular_org @RheumNow @CRASCRRheum @earlyarthritis Good question. I suspect it may be a class effect but would be good to see H2H btw JAKs one day. If selective JAK 1 inhibition provides more, less or same efficacy is still not clear to me
Olga Petryna DrPetryna ( View Tweet)
Don’t forget significant fibrosis with ILD has +RCT with nintedanib INBUILD study. Lots of buzz of RA ILD where MTX is OK, TNFi may have more ILD than other bDMARDs, biomatkers KL-6 @eular_org OP0038 #EULAR2020 @CRASCRRheum https://t.co/OihF3LmNYQ
Janet Pope Janetbirdope ( View Tweet)
#EULAR2020 OP0096 Dr. L Chatzis study on Sjogren:
1. 2nd most common autoimm dz in women
2. women:men ratio 20:1 (not 9:1)
3. 2 types Ro-Ab: nuc. Ro60 (assc w/La)and cytopls. Ro52 (assc w/ILD/myositis)
4. Seroneg. Sjogren's (neg Ro/La/RF) good prognosis:⬇️lymphoma
@RheumNow https://t.co/fV3ltQqnkf
k dao KDAO2011 ( View Tweet)
NPSLE is more than a headache! probs with dx, uncertain Rx, overlap with common probs - infection, pain, fibromyalgia, drug side effects, etc. Spectrum in NPSLE just like SLE has a spectrum of cutaneous findings T Huizanga discusses @eular_org #EULAR2020 @RheumNow @CRASCRRheum https://t.co/sdw0xavWBq
Janet Pope Janetbirdope ( View Tweet)
Dan Clauw: obese patients with chronic pain reported improved pain levels very early with low calorie diet, long before weight loss, suggesting the diet may be having a more direct effect. https://t.co/aZDOtBd9mz
Stefan Siebert StefanSiebert1 ( View Tweet)
Majority are correct. 1/3 of SAPHO meet PsA criteria esp if no osteitis @RheumNow @eular_org @CRASCRRheum @earlyarthritis #EULAR2020 https://t.co/B9wp8JxWpI
Janet Pope Janetbirdope ( View Tweet)
What % of SAPHO pts do you think have PsA? More if synovitis Less if osteitis #EULAR2020 @eular_org @RheumNow @CRASCRRheum AB0038
Janet Pope Janetbirdope ( View Tweet)
When making a dx of neuropsychiatric SLE I order labs AND @RheumNow @eular_org @CRASCRRheum @earlyarthritis #EULAR2020
Janet Pope Janetbirdope ( View Tweet)
#Upadacitinib #psoriaticarthritis Upa works in PsA including imaging and when they show it surprising good PASI scores as well https://t.co/ZWqj8ythHB
Peter Nash drpnash ( View Tweet)
#guselkumab #axialdisease - who would have thunk it - IL23 p19 works in axial involvement PsA with radiology! https://t.co/TaSFBJFRnx
Peter Nash drpnash ( View Tweet)
Can we predict which RA pts will have secondary failure to TNFi in advance?
B-cell activating factor (BAFF) may play a role, and in age >54, pre-TNFi BAFF levels predict anti-drug Ab.
A potential step toward better drug survival?
La Paz, Madrid THU0170 #EULAR2020 @RheumNow https://t.co/NRQHO2cVuf
David Liew drdavidliew ( View Tweet)
MTX in GCA (+/- TCZ): can GiACTA data provide insights?
MTX didn't add anything from data provided, but channelling bias a definite issue (note PNL numerically higher in non-MTX).
MTX as adjunct/cover post-TCZ? We'll need to test for it properly
FRI0220 #EULAR2020 @RheumNow https://t.co/BCsEKqqaMh
David Liew drdavidliew ( View Tweet)
Predictors of not achieving remission in early RA, in Canadian CATCH cohort vary by sex:
men: seropos, smokers
women: obesity, TJC, lower education
Different mechanisms of poor outcomes in early RA in men and women?
@earlyarthritis SAT0053 #EULAR2020 @RheumNow https://t.co/fRgm6vtlPL
David Liew drdavidliew ( View Tweet)
The link between periodontal disease & anti-CCP seroconversion is well known, but does it affect progression from arthralgias to synovitis after that?
@LeedsBRC data says yes for localised periodontitis.
Got CCP+ arthralgia? Don't forget to floss!
SAT0045 #EULAR2020 @RheumNow https://t.co/CpqRyIWVK0
David Liew drdavidliew ( View Tweet)
Primary Sjogren’s syndrome showed benefit of leflunomide + #Hydroxychloroquine vs placebo - past neg RCT of HCQ for PSS Sicca (dry eyes/mouth) so is it just leflunomide that works or combo? Likely pt selection - arthritis and rash likely respond to either @RheumNow @CRASCRRheum https://t.co/lsIeG2uv2H
Janet Pope Janetbirdope ( View Tweet)
For a drug that everything in RA has been built on, we're not great at predicting who will respond to methotrexate.
It's probably because we don't have all the info. Adding pharmacogenomics increased optimal AI prediction from 55% to 76%
@MayoClinic FRI0046 #EULAR2020 @RheumNow https://t.co/bwpSYQIBLG
David Liew drdavidliew ( View Tweet)
Filgo reduces PsA markers OP0224. ? Unique to filgo, a JAK1 effect , class effect or part of any effective PsA Rx or some of the above? @eular_org @RheumNow @CRASCRRheum @earlyarthritis #EULAR2020 https://t.co/2O5wsLPNl2
Janet Pope Janetbirdope ( View Tweet)
I've heard people say FDG uptake on PET/CT in PMR/GCA is just a correlate of systemic inflamm.
Look at the uptake intensity (SUVmax) vs inflamm markers in n=65 PET/CT in GCA. There's no pattern whatsoever.
Not just an expensive ESR!
@FreemanHospital SAT0272 #EULAR2020 @RheumNow https://t.co/D4xAZC7KmO
David Liew drdavidliew ( View Tweet)
In this unprecedented time, I must thank #EULAR2020 and @RheumNow for keeping all of us focused on the future. It’s inspiring and I needed the reminder! @KDAO2011 @CCalabreseDO @drdavidliew @DrPetryna @philipcrobinson @LCalabreseDO @RonanTKavanagh
Dr. Rachel Tate uptoTate ( View Tweet)
