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RheumNow Podcast – Cancer Risk in Systemic Sclerosis (9.27.19)

d Jack Cush, MD

Dr. Jack Cush reviews the news and articles from the past week on RheumNow.com.

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MMWR: Increased Opioid Use in Lupus

d Jack Cush, MD

Opioids are generally not indicated for pain in systemic lupus erythematosus (SLE) and other rheumatic diseases because of limited efficacy and risks for preference and adverse health effects.

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Low Dose IL-2 Effective in Lupus

d Jack Cush, MD

A double-blind, placebo-controlled clinical trial of low-dose IL-2 in patients with systemic lupus erythematosus (SLE) has shown that low-dose IL-2 induced was clinically effective while expandng regulatory T cells and NK cells, which may benefit immune homeostasis in SLE patients.

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Arthritis Foundation Releases First CBD Guidance for Adults With Arthritis

d Jack Cush, MD

As the leading organization for people with arthritis, the Arthritis Foundation has just released the first CBD guidance for adults with arthritis. CBD, or cannabidiol, a plant-based compound, has become popular among people with arthritis seeking to ease chronic joint pain.

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ACR Responds to CY2020 Medicare Physician Fee Schedule Proposed Rule

d Jack Cush, MD

Rheumatology leaders commend CMS for proposing E/M code changes and urge agency to make additional changes to final rule.d

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Persistent Inflammatory Arthritis After Immune Checkpoint Inhibitors

d Jack Cush, MD

Braaten and colleagues from Johns Hopkins School of Medicine have reported their experience with chronic inflammatory arthritis induced by immune checkpoint inhibitor therapies, showing that in some, inflammatory arthritis persists after the immunotherapy has been discontinued.

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Parenteral Out-Performs Oral Weekly Methotrexate

d Jack Cush, MD

A systematic review in PLOS suggests that parenteral MTX therapy is more successful than oral MTX in achieving optimal disease activity control. 

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Survey for Rheumatologists - You would use an MRI in an RA to assess what?

Dr. John Cush RheumNow ( View Tweet)

5-factor score for mortality in ANCA-associated vasculitis. I’ve never seen a worse Kaplan-Meier survival curve for those with a score of 5! @philseo #CCRwest 😬☠️ https://t.co/utK7avZ0F1
Jeff Sparks jeffsparks ( View Tweet)
The RheumNow Podcast is up - Watch it here>> https://t.co/PolTYQqbBW or listen to the podcast on iTunes, or SoundCloud>> https://t.co/ILQQw2kpse

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Dr. John Cush RheumNow ( View Tweet)

The RheumNow Podcast is up - discussing PSS & Cancer, SLE & narcotics, AAV & Lipids, Anakinra & NIDDM. Watch it here>> https://t.co/PolTYQqbBW or listen to the podcast on iTunes, or SoundCloud>> https://t.co/ILQQw2kpse

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Dr. John Cush RheumNow ( View Tweet)

TIF1-γ antibodies may be associated with dermatomyositis and are found in between 13 – 31% of adults and 22 – 29% of children. TIF1-γ antibodies have a strong association with malignancy, esp in patients over the age of 39. https://t.co/0o2VfNwbZC

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Dr. John Cush RheumNow ( View Tweet)

Dr. Rob Speira & HSS investigators will lead a multicenter, phase II, 6 mos clinical trial of anti-GM-CSF (mavrilimumab) in patients with giant cell arteritis (GCA. There is still heavy reliance on steroids in GCA; tocilizumab was FDA approved in in 2017 https://t.co/zDWgSVuXec

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Dr. John Cush RheumNow ( View Tweet)

Question for Rheumatologists - How do you scoreboard your performance as a Rheumatologist?

Dr. John Cush RheumNow ( View Tweet)

41 participants with RA and T2D were randomised to recv anakinra or a TNFi; RA dz activity decreased in both groups over 6 mos. Anakinra significantly improved A1C at 3 and 6 mos, but TNFi did not. https://t.co/UIBsRjMbKR

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Dr. John Cush RheumNow ( View Tweet)

JAMA study shows inconsistencies and inaccuracies in EMR documentation of ROS and PE findings compared to observer audible recorded observations - study of 9 ED Residents, 30 pt encounters each, total of 180 ED patients. https://t.co/PttGYvgCue

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Dr. John Cush RheumNow ( View Tweet)

Question for Rheumatologists - How do you scoreboard your performance as a Rheumatologist?

Dr. John Cush RheumNow ( View Tweet)

Systemic sclerosis is associated with an increased cancer risk. A cohort of 1727 SSc pts showed an increased cancer SIR of 2.15 (CI 1.84‐2.49). Most common cancers were breast, melanoma, hematological & lung. CA risk higher w/ RNAP III Ab, CCB Rx & ILD https://t.co/q5iTRI91Ng

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Dr. John Cush RheumNow ( View Tweet)

FDA issues warning against the use of higher doses of Imodium (loperamide) - has been associated with "serious heart problems and deaths with much higher than the recommended doses of loperamide". https://t.co/UxPn6F6BL0

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Dr. John Cush RheumNow ( View Tweet)

Altoona Arthritis Center and Dr. Alan Kivitz praised in the news for their unique blend of patient care and clinical trials research https://t.co/9kGLBhwzsn

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Dr. John Cush RheumNow ( View Tweet)

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