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Lower Risk of Diabetes with Abatacept

d RheumNow

 Patients with rheumatoid arthritis (RA) treated with abatacept (Orencia) had a lower risk of developing diabetes mellitus compared with those receiving certain tumor necrosis factor (TNF) inhibitors, a large cohort study suggested.

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A Role for Netosis in COVID-19 Infection?

d Jack Cush, MD

Journal of Experimental Medicine has published a paper from a consortium of researchers at Cold Spring Harbor Laboratory, the Feinstein Institutes for Medical Research, and the Research Institute of the McGill University Health Centre (RI-MUHC) on the potential of neutrophil extracellula

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Tuesday Nite Rheumatology Grand Rounds - Febrile Disorders

d Jack Cush, MD

Dr. Jack Cush reviews the appproach to evaluating fever in adults suspected of having a rheumatic disease, Stills disease or autoinflammatory conditions.

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RheumNow Podcast – Drive Them Crazy (4.17.20)

d Jack Cush, MD

Dr. Jack Cush reviews the news, journal articles and new ACR COVID-19 guidelines from the past week on RheumNow.com.

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Study from the National Inpatient Database shows that #RA pts have increased risk of hospitalizations for acute myocardial infarction. But compared to nonRA STEMI+ MI, RA- MI had a lower in-hospital mortality and cardiac arrests. https://t.co/lFHkqSgXbp

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Dr. John Cush RheumNow ( View Tweet)

An immunogenicity study w/ live ZOSTAVAX given ~2-wks before tofacitinib showed after mean 27 mos - 5 of 100 TOFA rx pts developed H. Zoster (at 218, 280, 748, 741, 544 days post-vaccination). OOOPs; not very protective. Use Shingrix! https://t.co/hEIJTCjJ3t

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Dr. John Cush RheumNow ( View Tweet)

GI experts COVID guidelines, state “Despite the potential for increased exposure to SARS-CoV-2, the limited available data and expert opinion suggest that patients with IBD do not appear to have a baseline increased risk of COVID-19infection" https://t.co/kGfIMJoZGI

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Dr. John Cush RheumNow ( View Tweet)

Last weeks TNR Grand Rounds on "Evaluating the Febrile Rheumatic Patient" is now available as a podcast for listening on iTunes or SoundCloud Part 1 https://t.co/R5OGoB42Zi and Part 2 https://t.co/CP3HOd982A

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Dr. John Cush RheumNow ( View Tweet)

Riociguat a guanylate cyclase stimulator w/ antiprolif & anti-inflamm effects studied in a DBRPCT in diffuse Systemic sclerosis; There was more improvement in mRSS (-2.09 vs -0.77), Raynauds (41% vs 26%) & FVC (2.7 vs 7.6) - but these were not significant https://t.co/7aEzdDxpVY

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Dr. John Cush RheumNow ( View Tweet)

NYU & Montreal Heart Instit. teaming on the COLCORONA study of Colchicine in early phase COVID-19 infx. TBD in 6,000 patients with mild forms of the disease. Dr. M Pillinger says colchicine, early on, may inhibit damaging inflammatory responses https://t.co/UTW2g6QU2r

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Dr. John Cush RheumNow ( View Tweet)

1st paper on the Global Rheumatology Alliance @rheum_covid registry published in Lancet Rheumatology. @ April 1st 110 COVID-19 Rheum pts enrolled from Europe, N&S America, Asia, Africa, Oceania; now up to 487 with 9894 in the patient survey. https://t.co/RI2AKsyf5T

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Dr. John Cush RheumNow ( View Tweet)

@LupusCanada has enhanced our survey to better understand the current situation and evolution of HcQ availability in Canada. Please share this survey with anyone impacted by this issue https://t.co/0ImHloC0JZ #LetsTalkLupus #LupusCanada #lupus

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Lupus Canada LupusCanada ( View Tweet)

Scary as hell ! The COVID-19 death rate in the USA doubles at least every 3 days..... https://t.co/u0UTLMf3NH

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Dr. John Cush RheumNow ( View Tweet)

Neurologic side effects of TNFi are rare; Sweden/Denmark population study shows TNFi in AS/PsA, but not in RA, associated with increased risk of neuroinflammatory events (0.59 to 0.87 /1000PY) with TNFi and 0.19-0.40/1000PY in unexposed https://t.co/FeRtKSspXj

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Dr. John Cush RheumNow ( View Tweet)

article in A&R details the Immunopathology, inflammatory mediators operative in cytokine storm syndrom of COVID-19 (and MAS/HLH), how to assess them and treatment options. Smart and timely article. (free read) https://t.co/3tsEVYMVRM

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Dr. John Cush RheumNow ( View Tweet)

Check out my take on the new ACR COVID-19 Guidance for Rheumatic Disease Patients - great suggestions; but I do have a few thoughts that differ....what do you think? https://t.co/8srDPYRo0b

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Dr. John Cush RheumNow ( View Tweet)

The RheumNow Podcast is up! Chikungunya, OI in kids, Dementia in RA, CPPD, COVID systemic dz and ACR COVID Guidelines; watch it here>> https://t.co/Y8Thiavero or listen to the podcast on iTunes or SoundCloud here>> https://t.co/G8ixVQCWG4

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Dr. John Cush RheumNow ( View Tweet)

Dr M Drazner ⁦@UTSWNews⁩ Grand Rounds on #COVID19 pts w/cardiac involvement may be afebrile ⁦@RheumNow⁩ https://t.co/nKUJe1HIdl

k dao KDAO2011 ( View Tweet)
Great image, from a review article found here: https://t.co/dTjrqclrvy https://t.co/SwKiCfyqEX

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Dr. John Cush RheumNow ( View Tweet)

Does Allopurinol lower mortality in gout? Metanalysis of 4 studies were split 2 yes, 2 no and overall all-cause mortality just missed significance with and adjusted HR 0.80 (95%CI (0.60, 1.05). https://t.co/sTB0Aq1lPd

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Dr. John Cush RheumNow ( View Tweet)

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