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High Dose Chloroquine Harmful in Severe COVID-19

d Jack Cush, MD

JAMA Open Network reports an interim analysis of the Brazilian CloroCovid-19 trial showing thta higher doses of chloroquine (CQ) in the treatment of severe COVID-19 was associated with QTc interval prolongation and increased mortality.

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RheumNow Podcast – In Times of Trouble (4.24.20)

d Jack Cush, MD

Dr Jack Cush reviews the news, journal reports, twitter feed and COVID developments from the past week on RheumNow.com

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How Has COVID-19 Affected You?

d Jack Cush, MD

I need your HELP and INPUT.

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Potential Role of B Cells in COVID

d Jack Cush, MD

A pre-proof letter to the editor in the Journal of Allergy and Clinical Immunology presents a series of patients with immunoglobulin deficiency disorders and how they differentially responded when infected with the coronavirus.

They identified seven Primary Antibody Deficiencies patients with COVID-19 infection; five affected with Common Variable Immune Deficiencies and two affected with Agammaglobulinemia, one with X-linked Agammaglobulinemia and one with Autosomal Recessive Agammaglobulinemia.

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FDA Consumer Warnings on Cannabis and CBD

d Jack Cush, MD

The FDA issued a new consumer update on what you need to know about Cannabis or Cannabis-derived Compounds, Including CBD. This is part of the FDA effort to answer questions about the science, safety, and quality of products containing cannabis and cannabis-derived compounds, particularly CBD.

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NIH Consensus Guidelines for the Treatment of COVID-19

d Jack Cush, MD

A National Institutes of Health (NIH) expert panel has developed consensus treatment guidelines for the management of coronavirus (COVID-19). To date no drug has been proven to be safe and effective for treating COVID-19. Moreover, they found no evidence to recommended the use of hydroxychloroquine for prophylaxis or treatment of COVID-19 outside of a current clinical trial.

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The RheumNow Podcast is up! "In times of Trouble". Watch it here>> https://t.co/gapTwq3REW or listen to the podcast on iTunes or SoundCloud>> https://t.co/dpoCoX8qBR

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Dr. John Cush RheumNow ( View Tweet)

"Yeah, you might beat me today, but then you’re gonna have to fight me again tomorrow and the day after that and every single day from now on until I kick the #$%! out of you, which I will.” - William Costanzo

Dr. John Cush RheumNow ( View Tweet)

The RheumNow Podcast is up! "In times of Trouble". ABA and DM, Zostavax fails, 3d Doubling rate, population testing, HCQ in COVID; Watch it here>> https://t.co/gapTwq3REW or listen to the podcast on iTunes or SoundCloud>> https://t.co/dpoCoX8qBR

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Dr. John Cush RheumNow ( View Tweet)

"Stay in your seat come times of trouble. Its only people who jump off the roller coaster who get hurt." - Paul Harvey

Dr. John Cush RheumNow ( View Tweet)

Perhaps love is like a resting place, a shelter from the storm. It exists to give you comfort, it is there to keep you warm, and in those times of trouble when you are most alone, the memory of love will bring you home." - John Denver

Dr. John Cush RheumNow ( View Tweet)

There’s a saying that anyone driving faster than you is crazy and anyone driving slower doesn’t know how to drive. Similar with COVID-19: anyone taking more precautions than you has an anxiety issue and anyone taking fewer is an idiot.

Adam Cifu adamcifu ( View Tweet)

Dr C Kershaw @UTSWNews grand rounds on ventilation in #COVID19 Why putting pts in prone position might help with ARDS ⁦@RheumNow⁩ https://t.co/I0AOx72Jwl
k dao KDAO2011 ( View Tweet)
ACR Guidance for Rheumatic Disease during COVID-19 pandemic #Rheumatology @RheumNow https://t.co/vHav6g4p6Q
Maeve Gamble MaeveGamble ( View Tweet)
NICE guidelines on managing rheumatologic conditions during COVID-19 #Rheumatology @RheumNow https://t.co/dQcavsno5N
Maeve Gamble MaeveGamble ( View Tweet)
Dr. Kavanaugh said it well in his blog on the "Upside of Covid" Humanity is really shining thru these days. Im truly touched by all my patients who ask about my health and my safety during COVID-19 == we all have to look out for each other! https://t.co/BYI5LHybeV

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Dr. John Cush RheumNow ( View Tweet)

NY State study shows 13.9% of population to be COVID (+) by Antibody testing; (+) means previously exposed. (+) COVID results were not different between all age groups. Given 15,500 deaths in NY, that means the COVID death rate is 0.5% https://t.co/LCDPeBLy2r

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Dr. John Cush RheumNow ( View Tweet)

VA retrospective study shows worse COVID outcomes w/ HCQ. 368 COVID+ males, Rx w/ 97 HCQ, 113 HCQ + azithromycin, 158 noHCQ. Death Rates: HCQ 27.8%, Combo 22.1%; 11.4% control. Ventilator use not different. https://t.co/M86u2MqMh8

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Dr. John Cush RheumNow ( View Tweet)

2 Canadian studies BioTrac & OBRI, w/ RA 1376 pts found 14-18%, D/C TNFI for nonresponse. Primary NR 66-87% failed to achieve LDA by DAS28-ESR, or 66-91% by CDAI. 19-61% Primary NR D/C w/in 6 mos; 61-87% of 2nd NR discontinued >12 mos https://t.co/xegAogSAQx https://t.co/IyiAStXQLs

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Dr. John Cush RheumNow ( View Tweet)
Metanalysis of 1st line TNFi survival: 12 mos 24 mos 36 mos ETN 71% 63% 59% IFX 69% 57% 49% ADA 70% 59% 51% Does ETN have better survival? https://t.co/T4QVbI5lf7 https://t.co/mqsaADb7Uu

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Dr. John Cush RheumNow ( View Tweet)
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