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Phases preceding RA diagnosis.
@karen_kc123 @RheumNow #RNL2022 https://t.co/KJT9ml8ZJY
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Completed early RA prevention trial!
One dose of Rituximab at day zero in the PRAIRI Trial, delayed onset of RA diagnosis.
After 36 months mo difference .
@karen_kc123 @RheumNow #RNL2022 https://t.co/R3639V6b07
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Patient-centered, holistic approach in #multimorbidity management.
🔑 Patients with #RA and #MM need help and coaching in guiding and directing their care.
🔑 Good communication with healthcare provider is the key.
@RheumNow #RNL2022 https://t.co/iLrZAT0y9r
Elena MyasoedovaMD MyasoedovaElena ( View Tweet)
Approaching comorbidities!
Elena Myasoedova @RheumNow #RNL2022 https://t.co/Y3JNsBT9bJ
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
ACPA is a strong predictor for RA development.
any ACPA : 30% developed RA within 3 years.
High titer ACPA: 50% developed RA with 3 years.
Finally ACPA Titer Matters?!
@karen_kc123 @RheumNow #RNL2022 https://t.co/blbVovf1KZ
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Healthy behaviors (moderate EtOH, healthy body weight, no smoking, healthy diet, physical activity) associated with lower RA risk
"Chronic systemic inflammation fans the flames of brewing RA"
@RheumNow #RNL2022 https://t.co/gAerZaAcso
Robert B Chao, MD doctorRBC ( View Tweet)
Family history risk includes genetic and shared environmental factors
@RheumNow #RNL2022 https://t.co/3J4nisbSX1
Robert B Chao, MD doctorRBC ( View Tweet)
ACPA prior to RA diagnosis.
Notice epitope spreading proceeding diagnosis!!
@karen_kc123 @RheumNow #RNL2022 https://t.co/glgrOdVyyJ
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Completed Early RA prevention trials using agents like steroids, RTX, atorvastatin, abatacept
No sig difference in steroids, atorvastatin
RTX delayed onset but no overall diff
Abatacept decreased RA progression at 1.5 years
@RheumNow #RNL2022 https://t.co/v7WxI2P7r5
Robert B Chao, MD doctorRBC ( View Tweet)
@Janetbirdope on drug cycling in #RA. What’s beyond TNFi failure? No golden rule, but:
👉🏻 switching to non-TNF can be superior than staying with the TNFi class
👉🏻 response to other bDMARs maybe blunted in non-TNFi naive
👉🏻 JAKi can be a good choice for some @RheumNow #RNL2022 https://t.co/25MiiFh2CK
Elena MyasoedovaMD MyasoedovaElena ( View Tweet)
How NOT to get rheumatoid arthritis. Excellent tips by @karen_kc123 #RNL2022 #rheumatoidarthritis https://t.co/brLeWzioQD
Jonathan Hausmann MD hausmannMD ( View Tweet)
Patients often ask me what they can do on their part to help their disease... this is it! @karen_kc123 reviews the modifable risks in RA. @rheumnow #RNL2022 @CreakyJoints https://t.co/FM0BtNX6eb
TheDaoIndex KDAO2011 ( View Tweet)
#Rheumatoid arthritis- is it all or partially in your genes 🧬? Many genes are not sufficient or necessary to produce #RA. Genes were used in a study to predict development of RA better than clinical parameters. But not ready for prime time YET #RNL2022 @RheumNow @karen_kc123 https://t.co/J5aBs4iLbR
Janet Pope Janetbirdope ( View Tweet)
Dr. Elena Myasoedova on Multimorbidities and RA
Important to recognize multimorbities are 2-3x higher in RA and how it impacts our RA pts
@RheumNow #RNL2022 https://t.co/N6VPdU6wzV
Robert B Chao, MD doctorRBC ( View Tweet)
Cool idea 💡 for #treatment of #multimorbidity in #rheumatoid arthritis from an interactive web platform #RNL2022 @RheumNow https://t.co/QlTWCV8s9F
Janet Pope Janetbirdope ( View Tweet)
Role of cytokines in pain ?!
Notice CNS activity disappeared immediately before TJC/SJC improvement!!
@Tuhina_Neogi @RheumNow #RNL2022 https://t.co/TXKZwepBTF
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
@Janetbirdope on drug cycling vs. switching in RA
Interesting data showing switching to non-TNFi superior to cycling in TNFi-incomplete responders
Most bDMARDs and JAKi have blunted response post-TNFi
@RheumNow #RNL2022 https://t.co/Lb3wvHZdzN
Robert B Chao, MD doctorRBC ( View Tweet)
@Janetbirdope shares her study on real world retention of JAKi vs biologics in #RA #RNL2022 @rheumnow https://t.co/hNxQ8t4LHH
TheDaoIndex KDAO2011 ( View Tweet)
#ClinicalPearl #multimorbidity worsens outcomes in #rheumatoid arthritis. 50% of #RA pts has this and 2x > than age sex matched pop’n. Worse as interplay of diseases, drug disposition, med adherence, drug interactions, etc #RNL2022 @RheumNow Elena Myasoedova https://t.co/aTF0O8o0tg
Janet Pope Janetbirdope ( View Tweet)
Dr. Elena Myasoedova defines multimorbidity and its difference for comorbidities. Multimorbidity (MM) focuses on the patient, comorbidities focuses on the disease. RA pts have 2.3 X higher MM and can precede RA. #RNL2022 @rheumnow https://t.co/FE489rJnnP
TheDaoIndex KDAO2011 ( View Tweet)