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New ACR/AF Guidelines on JIA Polyarthritis and Uveitis

d Jack Cush, MD

The American College of Rheumatology (ACR) and the Arthritis Foundation (AF) have released two guidelines on management of juvenile idiopathic arthritis (JIA).

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Shorter Treatment Succeeds in Septic Arthritis

d RheumNow

Two weeks of antibiotic therapy was as effective as 4 weeks for septic arthritis, a prospective single-center study found.

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Targeting GM-CSF Works in Rheumatoid Arthritis

d RheumNow

Namilumab, a monoclonal antibody that targets the granulocyte-macrophage colony-stimulating factor (GM-CSF) ligand, showed promise as a treatment for rheumatoid arthritis (RA) in a phase II study.

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RheumNow Podcast – Take it Back Jack! (4.26.19)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com

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Naproxen has no Effect on Alzheimer's

d Jack Cush, MD

A randomized controlled trial shows that chronic low-dose naproxen does not reduce progression of presymptomatic Alzheimer disease (AD).

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More Studies Needed to Optimize the Use of Osteoporosis Drugs

d Jack Cush, MD

The Annals of Internal Medicine reports a metanalysis done to examine the optimal length of long-term osteoporosis drug treatment (ODT) and whether harms are associated with long-term ODT and while the ODT benefits are clear, the risk of rare harms and need for drug holidays is less certain.&nbsp

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Full Read review of CLE - cutaneous lupus from Werth and colleagues at UPenn. Focused on new therapies and clinical trial issues. https://t.co/NCB0IF7tWO

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Dr. John Cush RheumNow ( View Tweet)

Pectus carinatum or "Pigeon Chest" is a chest wall deformity w/ costal cartilage overgrowth pushing forward the manubrium/sterum; predominantly males (4:1F) also @ risk for scoliosis, Marfans, valvular/aortic disease, psychologic problems https://t.co/tL7vDfZDVT

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Dr. John Cush RheumNow ( View Tweet)

You can View all 16 hrs of RHeumNow Live for Free - register here and then View at your own pace. https://t.co/1jGiIQXvua

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Dr. John Cush RheumNow ( View Tweet)

Creaky Joints - a great website for patients with arthritis is now available in Spanish! https://t.co/xvApzvY2Hh

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Dr. John Cush RheumNow ( View Tweet)

FDA has approved Samsung-Bioepsis biosimilar version of etanercept - Eticovo (etanercept-ykro), approved in other countries under names Benepali and Brenzys. Approval based on 596 RA pt trial w/ 52 wk ACR20 of 80.8% and 81.5% (Enbrel arm) https://t.co/r3q9dQ0Bdb

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Dr. John Cush RheumNow ( View Tweet)

Benlysta is approved for use in pediatric SLE based on the 80 pt PLUTO trial; 1 yr of PBO vs 10 mg/kg belimumab plus standard therapy. Results presented at ACR2018 shows BEL in pediatric SLE to be safe and effective (SRI4 resp 52.8% vs 43.6%). https://t.co/cjqPaWu92O.

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Dr. John Cush RheumNow ( View Tweet)

RheumNow Podcast is up ! Cardiac risk in RA sibs; NSAIDS & Fx nonunion; Treating Calcinosis Cutis; whats a Skyrizi? Watch the video https://t.co/NNsUFcGkWT or listen to the podcast on iTUNES or SoundCloud >> htps//soundcloud/rheumnow/rheumnow-podcast-take-it-back-jack-42619

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Dr. John Cush RheumNow ( View Tweet)

Animal data suggests targeting of neutrophils in APS may mitigate thrombotic disease. Adenosine recept agonists suppresses aPL Ab-mediated NETosis & reduces IVC thrombosis. Same shown for dipyridamole (incr. adenosine & cAMP breakdown). https://t.co/BHACehh0lb

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Dr. John Cush RheumNow ( View Tweet)

Comparing nearly 230,000 Taiwanese with and without gout shows gout pts have more psoriasis (1.6% vs 1.1%; adjusted OR 1.30; 1.20-1.42) and psoriatic arthritis (0.3% v 0.1%; aOR 2.50; 1.95-3.22). https://t.co/c1ZVy5E6vk

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Dr. John Cush RheumNow ( View Tweet)

Vote on the NEJM Question of the week - Which one of the following vaccination regimens is recommended for a 62-year-old woman with systemic lupus erythematosus who is being treated with prednisone 5 mg daily? Go here to vote https://t.co/27an4cVdqv

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Dr. John Cush RheumNow ( View Tweet)

Biologic and Glucocorticoid Use after Methotrexate Initiation in Patients with Rheumatoid Arthritis https://t.co/kuX8X6l99V https://t.co/p4kr42piYy

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The Journal of Rheumatology jrheum ( View Tweet)
Another Step beyond the DEAs Take Back program that ocurrs twice a year (April and October), including Saturday April 27th - see my earlier tweet on this today https://t.co/WPt6VIboMW

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Dr. John Cush RheumNow ( View Tweet)

Results from Nationwide Inpatient Sample Database (2003–11) finds 31,439 obstetric hosp. in RA women who had a higher maternal age (30.5 yrs) & significantly more HTN, premature membr. rupture, antepartum hemorrhage, preterm delivery, IUGR & C sections https://t.co/pz5uQH5rrx

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Dr. John Cush RheumNow ( View Tweet)

Swedish population study compared 8109 RA pts and 11562 full siblings to the general population, finding the risk of acute coronary syndrome to be increased in RA (HR 1.46; 1.28 -1.67) and RA Sibs (HR 1.22; 1.09 - 1.38) w/ risks confined to seropositives https://t.co/oYUP3jgY60

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Dr. John Cush RheumNow ( View Tweet)

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