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CXCR3 and Restricted T Cells in Psoriatic Arthritis Inflammation

d Jack Cush, MD

Research from Oxford University suggests a potential pathogenic role for the chemokine CXCR3 and clonally restricted CD8+ T cells in the pathogenesis of psoriatic arthritis (PsA) based studies of PsA synovial fluid samples obtained by arthrocentesis from 11 patients with large-joint oligo Ps

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DMARDs for Early Rheumatoid Arthritis Have Cardiovascular Benefits

d RheumNow

Patients with RA have up to a three-fold increased risk of mortality versus the general population, largely due to an increased incidence of premature CVD, such as atherosclerosis and heart failure.

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RheumNow Podcast – Lupus Delights (9.18.20)

d Jack Cush, MD

Dr Jack Cush reviews the news and journal reports from the past week on RheumNow.com:

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COVID-19 Risks in Pregnant Women

d Jack Cush, MD

There has been little science or evidence regarding the effects of COVID-19 infection on pregnancy and vice versa; and now the recent MMWR addresses the subject with two new reports

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Methotrexate-Pegloticase Combination in Refractory Gout - MIRROR Study

d Jack Cush, MD

The MIRROR study, an open-label pilot trial in refractory, uncontrolled gout patients, showed that pegloticase given in combination with methotrexate was safe and effective and maintained responses for 6 months after initiation. 

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Belimumab Effective in Lupus Nephritis

d Jack Cush, MD

Dr. Rich Furie has lead a group of investIgators in reporting the significant efficacy of intravenous belimumab when added to standard of care induction therapy in patients with active lupus nephritis. This phase 3, 2-year study included 448 systemic lupus erythematosus patients with biopsy proven lupus nephritis (class III or IV +/- V) patients who required induction therapy and have a UPCR ≥1 g/g. 

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Outcomes survey of 229 relapsing polychondritis patients shows that 59% had auricular-onset (AO) and 21% had respiratory -onset (RO), 20% w/ miscellaneous-onset (MO- eye MSK CNS). Poorer prognosis seen in RO & MO subgroups than AO subgroups https://t.co/rzVU42z3EA

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Dr. John Cush RheumNow ( View Tweet)

6.6% Risk of Late-onset Neutropenia (ANC<1000) in a single center study of 738 Rx w/ Rituximab (107 LON in 71 patients). Incidence was 7.2/100PYs. Higher risk w/ SLE or CTX Rx. 40% had Sxs, Fever 31%, sepsis in 8.5%. Rechallenge in 87% & 21% recurrent LON https://t.co/XXFV1lH9jS

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Dr. John Cush RheumNow ( View Tweet)

Metanalysis presented at European Association for the Study of Diabetes (EASD), involving 1,629,854 participants and found #RA was associated with a 23% higher chance of developing T2D, compared to the diabetes risk within the general population https://t.co/Qff7gpzves

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Dr. John Cush RheumNow ( View Tweet)

As of 20 Sept, CDC reports total US COVID-19 deaths to be 198,754. In the last 7 days 281,490 new Cases. Trends flat averaging ~40,000 Cases per day and ~600-1100 deaths per day. https://t.co/CPLVhz6qeH

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Dr. John Cush RheumNow ( View Tweet)

In our September issue—Symmetric peripheral polyarthritis developed during SARS-CoV-2 infection https://t.co/IqHp2GMLao https://t.co/Prvw8OBTvH

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The Lancet Rheumatology TheLancetRheum ( View Tweet)
Lisa Sammaritano, MD, stresses that there must be communication between rheumatologists and OB-GYNs when it comes to addressing pregnancy for #rheumatology patients. #CCREast https://t.co/j1IH6gsKnk

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HCPLive MDMagazine ( View Tweet)

Thank you all who participated in the survey. Here are some of our results #Covid_19 #rheumatology https://t.co/55ETf6kK6T

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Bella Mehta bella_mehta ( View Tweet)

Dr. S. Louis “Lou” Bridges, Jr. (@HSS_PIC) shares what led him to HSS and what he hopes to do as the Chief of the Division of Rheumatology. For more about Dr. Bridges visit https://t.co/oNiQxlLFeP. https://t.co/2vcLwUZJYQ

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Hosp Special Surgery HSpecialSurgery ( View Tweet)
"It’s a very difficult transition for providers to care for patients without a physical exam." #rheumatology #telemedicine @DartmouthHitch https://t.co/ZSHmVqXDaT

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HCPLive MDMagazine ( View Tweet)

The RheumNow podcast is up! Lupus delights - Lupus & Diet, Drug induced lupus & brand new biologics for SLE. Good news on immunosuppressives, colchicine and baricitinib in COVID-19 patients. . Watch it here https://t.co/Ymsd3eXN5d or listen to the podcast https://t.co/20FOr3qu3X

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Dr. John Cush RheumNow ( View Tweet)

Lupus Delights https://t.co/20FOr3qu3X https://t.co/AdRoaLDAmt

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Dr. John Cush RheumNow ( View Tweet)
Doximity's 2020 State of Telemedicine report shows the top 10 specialties using telemedicine: 1. Endocrinology; 2. Rheumatology; 3. Gastroenterology, followed by Nephrology Cardiology GU Neurology Geriatrics Heme/onc Pulmonology https://t.co/J4Dt24ZlYg

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Dr. John Cush RheumNow ( View Tweet)

Nurses' Health Study (79,568 women) examined the role of diet in 194 incident SLE cases and showed that diets (DASH, Meditteranean, antiinflammatory & healthy diets) had no significant effect of dietary quality on SLE risk https://t.co/JAFirjt0O8

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Dr. John Cush RheumNow ( View Tweet)

NEJM report of 2 SLE pts treated w/ Daratumumab (anti-CD38) to deplete plasma cells a life-threatening refractory SLE. Clinical improvement associated w/ depletion of plasma cells, reduced IFN type I activity, down-regulation of T-cell transcripts https://t.co/K0fwpEHS81

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Dr. John Cush RheumNow ( View Tweet)

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