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#ACR18 @RheumNow abs 837 high dose flu vaccine in RA pts 2-3 times more likely to seroconvert vs standard dose. No increase in RA disease activity. ? translates to less flu?
Ian N Bruce Lupusdoc ( View Tweet)
#ACR18 @RheumNow abs 838 MDA5 pos DM-ILD. Hi dose steroids + tac + IV CycloP had 85%survival at 12m vs 33% in historic controls. Note 31%also had PEx. 90%had CMV reactivation. Impressive nevertheless. #RareDisease
Ian N Bruce Lupusdoc ( View Tweet)
Safety and Immunogenicity is one of nine educational videos available in the "Therapeutic Update: Biosimilars in Rheumatology" video series, sponsored by Sandoz, Inc. and now available on RheumNow. https://t.co/1vmnEJqOSi
#biosimilars
Links:
Dr. John Cush RheumNow ( View Tweet)
IgG4-related disease... almost completely unknown 10 years ago.
"It is a perfect disease for rheumatologists to take care of." - Dr. John Stone #ACR18 @RheumNow
Brittany A MissbeeMD ( View Tweet)
IgG4-RD histopathology consistent across organs: lymphoplasmacytic infiltrate, obliterative phlebitis, storiform fibrosis.
#ACR18 @RheumNow
Brittany A MissbeeMD ( View Tweet)
Pearls regarding IgG4-RD. Depressed complements commonly seen in renal involvement. #ACR18 @RheumNow https://t.co/m3oM4Aiuny
Brittany A MissbeeMD ( View Tweet)
#IgG4 RD is an indolent disease but can present with severe weight loss (>20 pounds), largely due to pancreatic destruction.
#ACR18 @RheumNow
Brittany A MissbeeMD ( View Tweet)
Therapeutic potential of “glycoengineering" in autoimmune disease.
Alter glycoforms of endogenous IgG -> reduce pathogenic impact of antibodies.
Cell paper by Pagan JD et al
https://t.co/UbBsE1jV4L
Year in review basic science
#ACR18 @RheumNow
D White WIRheum ( View Tweet)
TLR8 aberrantly expressed on pDCs (cells that make type-I IFN) in SSc patients
Depletion ameliorates disease
https://t.co/SmDdpIU2I1
Ah Kioon et al
Year in review basic science
#ACR18 @RheumNow
D White WIRheum ( View Tweet)
Stop by the @RheumResearch booth to get your @alhkim autographed flyers!!! #acr18 #rheumrockstars https://t.co/kVR4XB6ynO
Mary J. Wheatley MaryJWheatley ( View Tweet)
Anti-GBM positivity did not predict relapse in Goodpasture's
(but ANCA did predict relapse in GBM disease)
Abs 826, Cleveland Clinic
Roundup - Cush, Kavanaugh
#ACR18 @RheumNow
D White WIRheum ( View Tweet)
Toci in SSc
failed to achieve primary endpoint (modified Rodman skin score)
Abs 898
Roundup - Cush, Kavanaugh
#ACR18 @RheumNow
D White WIRheum ( View Tweet)
Canabinoids in vitro
CB2 receptor drives inflammation
Set the stage for discovery/development of future antagonists?
Danger of over-interpretation on the street
Abs 1068
Roundup - Cush, Kavanaugh
#ACR18 @RheumNow
D White WIRheum ( View Tweet)
MTX for OA of the knee
12 months, 155 pts, endpoint=pain
statistically significant improvement, probably not clinically meaningful
consistent with prior reports
Abs 428
Roundup - Cush, Kavanaugh
#ACR18 @RheumNow
D White WIRheum ( View Tweet)
B cell immunology
New therapies directed at B cells
Overlap with therapies for myeloma
How to target long-lived (CD20 neg) plasma cells?
Session: ACR immunology update
Roundup - Cush, Kavanaugh
#ACR18 @RheumNow
D White WIRheum ( View Tweet)
Session on draft ACR reproductive health guidelines
Three manuscripts in preparation
This effort is a response to a tremendous need for info and guidance
Estimated half of pregnancies are unplanned, so ask patients often
Roundup - Cush, Kavanaugh
#ACR18 @RheumNow
D White WIRheum ( View Tweet)
MTB screening in patients on TNFi
When to re-screen?
Neg to pos conversion discovered in a small number of cases
Often in patients with risk factors
Cush: Annual testing “makes no sense at all"
Abs 1234, Rochester NY
Roundup - Cush, Kavanaugh
#ACR18 @RheumNow
D White WIRheum ( View Tweet)
DIP involvement in RA
12k patients in Japanese registry
2% incidence, 2-3 joints in each pt with involvement
associated with higher disease activity
Abs 221
Roundup - Cush, Kavanaugh
#ACR18 @RheumNow
D White WIRheum ( View Tweet)
Biosimilars in Sweden
Rx patterns (originator vs biosimilar) follow prices - back and forth
Abs 1175
Roundup - Cush, Kavanaugh
#ACR18 @RheumNow
D White WIRheum ( View Tweet)
Gout
Remains under-treated
Higher success when pharmacists and RNs manage ULT
Abs 2220, 1247, 1272
Roundup - Cush, Kavanaugh
#ACR18 @RheumNow
D White WIRheum ( View Tweet)