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Have a Rheumatology question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology.
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Dr. John Cush RheumNow ( View Tweet)
Tremendously emotional (and unfiltered) first person account of his fight with COVID-19 by Miracle Larry who thanked our Dr. Cush @RheumNow for his ingenuity in fighting COVID-19, thanking healthcare workers for all they do, and reminding us to be empathic.
#RNL2023 https://t.co/i0D7r8dR8n
Robert B Chao, MD doctorRBC ( View Tweet)
Multicenter study of 1516 MIS-C pts - Initial Rx: 13% recv anakinra (w/ or w/o) otherdrugs; 64% rx w/ IVIG & steroids, 16%IVIG alone, 4% steroids alone. Anakinra gave no short-term CV benefits over IVIG and glucocorticoids alone. https://t.co/IVaC5dXzs8
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Dr. John Cush RheumNow ( View Tweet)
CDC says EVERYONE should be tested for Hepatitis B al least once, w/ 3 lab - HBsAg, & Abs to hepatitis B surface Ag (anti-HBs), hep B core Ag (anti-HBc). At increased risk for HBV - persons in jail, +Hx of STDs, multiple sex partners or Hx of hepatitis C https://t.co/DRzAuhVJSJ https://t.co/9ma0I61xeD
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Dr. John Cush RheumNow ( View Tweet)
1215 pts w/ refractory SJS/TEN (not responding to pulse steroids x 3d) compared subsequent plasmapheresis- vs IVIG treated patietns and shows similar mortality rates(18.3% vs 19.5%), but apheresis had more stays (45 vs 32 d) & cost ($34k vs $23k) https://t.co/QTnbPzf6Jd https://t.co/EgI2ueIhdz
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Dr. John Cush RheumNow ( View Tweet)
Study of 21 Downs syndrome pts shows DS to be an autoimmunity-prone state, with a steady-state cytokinopathy, and evidence of hyperactivated CD4 T cells and ongoing activated B cells (CD11c+) - all contribute to a breach in immune tolerance. https://t.co/UUEByfBrqk https://t.co/ekq8AHYlxQ
Dr. John Cush RheumNow ( View Tweet)
Bullous pemphigoid is an autoimmune blistering Dz that may be seen with other hematologic dz - hemophilia A, hypereosinophilic syndrome, autoimmune thrombocytopenia, aplastic anemia, Heme malignancy (MDS, CLL, etc) https://t.co/i8WdA28hYP https://t.co/RsJMt9RTNl
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Dr. John Cush RheumNow ( View Tweet)
ENT involvement studied in 320 ANCA associated vasculitis pts: 65% had ENT involvement w/ median age =52 yrs, & median BVAS3 = 12. Relapse seen in 29% despite immunosupp Rx. No diff in outcomes betw pts Rx w/ oral or IV CTX or RTX https://t.co/MwZSnVVd32 https://t.co/YbrHxnqDw9
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Dr. John Cush RheumNow ( View Tweet)
QD Clinic - Double Positive, but Few Joints
Lessons from the clinic brought to you by RheumNow Live, March 18 &19, 2023 - Dallas, TX
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Dr. John Cush RheumNow ( View Tweet)
Metanalysis shows Takayasu's arteritis pts are at higher risk of adverse pregnancy outcomes. (27 studies, 825 pregs) showed more miscarriage (16%), hypertension (37%) and pre-eclampsia (14%) in TA patients (p < 0.01) https://t.co/kyUNgcsIPD https://t.co/KA1otftKTc
Dr. John Cush RheumNow ( View Tweet)
Massachusetts Medical Society workforce survey (600 MDs) shows that >half have cut back patient time, 55% admitted to burnout (more in women), & 1 in 4 physicians plan to leave medicine in the next two years. https://t.co/VUd101BrEi https://t.co/Hc6UyGMW1E
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Dr. John Cush RheumNow ( View Tweet)
VTE Options
QD Clinic - Lessons from the clinic, brought to you by https://t.co/4UQlqwujiR March 18 &19, 2023 - Dallas, TX
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Dr. John Cush RheumNow ( View Tweet)
Im not sure this was necessary but - a metanalysis of 10 RCTs w/ 847 OA patients shows colchicine use in osteoarthritis had no efficacy as far as pain reduction (vs control; SMD= 0.17) & no improvement in function (SMD, - 0.37) https://t.co/pDR0XO6vCg https://t.co/o8yYByBj8I
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Dr. John Cush RheumNow ( View Tweet)
New Drug Formulations – For Patients or Profits?
Wang et al in JAMA Network Research Letter, reviewed Medicaid expenditures on ADA, noted that the introduction of the citrate-free formulation cost an extra $4.4B to Medicaid from 2014-2021.
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Dr. John Cush RheumNow ( View Tweet)
Heavy Metals and the Risk of Arthritis
The etiology of arthritis was studied using US NHANES data and suggested that elevated concentrations of trace elements (TE: Pb, Cd, and Cu) were associated with increased risk of arthritis.
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Dr. John Cush RheumNow ( View Tweet)
Danish Pop. study of frequency of TMJ and oro-facial Dz in 613 pts w/ #JIA followed 4 yrs. Cumulative incidence of TMJ dz was 30%; 21% had arthritis-induced dentofacial deformity & dentofacial dysfunction (52%). TMJ predicted by younger onset, F, ANA+ https://t.co/M39q3snO3n https://t.co/ajPz27lmvt
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Dr. John Cush RheumNow ( View Tweet)
Differential Dx of Granulomatous Myopathy: Sarcoidosis, inclusion-body myositis, myasthenia gravis, Crohns, GPA, TB, brucellosis, syphilis, PBC, RA, systemic sclerosis , lymphoma, checkpoint inhibitors, GVHD, natural killer/T-cell lymphoma https://t.co/5IUaC1ln7G https://t.co/guYtvyaaHU
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Dr. John Cush RheumNow ( View Tweet)
S.Korean population based study shows the frequency of pregnancy induced de Quervain's tenosynovitis (DQT) between 2013-17 was 2.1% of all preg women. Risk factors: ≥ 30 yrs, multiple gestation, C-Section, HTN in preg, RA (DM not a risk) https://t.co/JaOQhaX5rL https://t.co/cl6RZLfXds
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Dr. John Cush RheumNow ( View Tweet)
Implantable Vagal nerve stimulation studied in 17 active #RA pts DAS ~6. Dr Eric Ruderman #RWCS23 https://t.co/GgjdcfuVud https://t.co/EpuGgApOq5
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Dr. John Cush RheumNow ( View Tweet)
“Pathology is helpful but not diagnostic” Dr. Dua #RWCS23 @RheumNow here are your features found on biopsy. https://t.co/J9a6S9XY2D
Dr. Rachel Tate uptoTate ( View Tweet)
