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CARRA Consensus Treatment for Refractory Juvenile Dermatomyositis
CARRA has developed consensus treatment plans for the use of biologic disease-modifying antirheumatic drugs (bDMARDs) in patients with refractory, moderately severe juvenile dermatomyositis. Juvenile dermatomyositis is the most common form of idiopathic, inflammatory myositis in childhood, with an estimated incidence of 3.2 per million children per year in the United States.
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Lead with Lupus (8.2.2024)
Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com - leading with lupus because everyone wants to know about lupus!
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Frequency and Features of CPPD
An international cohort study of patients with calcium pyrophosphate deposition (CPPD) disease, i.e., recurrent acute CPP crystal arthritis, chronic CPP crystal inflammatory arthritis, and crowned dens syndrome (CDS) identifies both acute and chronic inflammatory phenotypes, each with distinctive clinical and imaging diagnostic features.
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Full Read Overview of the safety of bDMARDs/tsDMARDS - contraindications, precautions, & boxed warnings for treatment of RA, PsA, SpA, JIA - safety checklist for a class of drugs you use and diseases you treat https://t.co/TIdCtJjF21 https://t.co/UE0nGbESDB
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Dr. John Cush RheumNow ( View Tweet)
Study of 136 referred LBP pts (71 w/ DDD, 38 DISH, 27 axSpA) found significant overlap of imaging features in all 3. SpA-like spine CR features were found in 1/4 of patients with DISH, and MRI BM edema found in 1/3 of those patients. https://t.co/dKIcuE3IGZ https://t.co/OITtOKEuNC
Dr. John Cush RheumNow ( View Tweet)
Decline in Physician Trust During the COVID-19 Pandemic
AMA reports that following the COVID-19 pandemic US adults trust in physicians and hospitals decreased, and was associated with lower odds of COVID vaccination.
https://t.co/3XcMYcnzD3 https://t.co/yiIvOp1o5a
Dr. John Cush RheumNow ( View Tweet)
Frequency and Features of CPPD
An international cohort study of patients with CPPD disease identifies both acute and chronic inflammatory phenotypes, each with distinctive clinical and imaging diagnostic features.
https://t.co/3ox3YjVh5w https://t.co/1pB9f42a9M
Dr. John Cush RheumNow ( View Tweet)
Ischemic Forearm Exercise Testing is used to Dx McArdles disease & the absence of elevated blood lactate levels during exercise in pts w/ myophosphorylase deficiency (McArdle disease) https://t.co/pNxl6qnnIR https://t.co/kOyk45Necd
Dr. John Cush RheumNow ( View Tweet)
NEJM Case: A 29-year-old woman with SLE presented to the dermatology clinic with 2-weeks of itchy, painful rash on her nose and hands that came on with cold weather. What do you think? https://t.co/jm0Zzu1gfj https://t.co/sAgZipPmaC
Dr. John Cush RheumNow ( View Tweet)
Study of 201 pts w/ chronic pain, prevalence of anxiety was 19%; higher in women (OR 7.94) longer pain (OR:1.3) & severe pain(OR:18.7) https://t.co/LD6pjH25qv https://t.co/mrlEo0UkEw
Dr. John Cush RheumNow ( View Tweet)
2024 EULAR Points to consider when treating patients with cancer
https://t.co/oXO8m8mrfJ https://t.co/v69zPteDr0
Dr. John Cush RheumNow ( View Tweet)
Pain Reduction with Methotrexate in Knee Osteoarthritis
The Annals of Internal Medicine reports that oral, low dose, weekly methotrexate significantly reduced knee osteoarthritis (KOA) pain, stiffness, and function in a randomized controlled trial.
https://t.co/ayMD1V67fH https://t.co/Es3oPYM8Y3
Dr. John Cush RheumNow ( View Tweet)
Medical literature review of suggests low vitamin D status is common in Rheumatic pts. & low vit D levels linked to loss of muscle strength, MSK pain, sarcopenia & falls (esp in IIM, PMR, SLE, RA, SSc) (BUT DOES REPLACING VITAMIN D FIX THESE PROBLEMS???) https://t.co/30IiKj7l4d https://t.co/ydU6FQMTi5
Dr. John Cush RheumNow ( View Tweet)
PEXIVAS: Diffuse Alveolar Hemorrhage in ANCA-Associated Vasculitis Patients
The PEXIVAS study found potential benefits of plasma exchange and glucocorticoids for AAV patients with DAH, but the results did not reach statistical significance.
https://t.co/m7BxMfj04W https://t.co/A9SKAWd1s5
Dr. John Cush RheumNow ( View Tweet)
Calcinosis cutis affects 40% of SSc pts w/ significant morbidity. Assoc w/ Long Dz duration, vascular dysfunction, & osteoporosis. Dx by radiography. Surgical treatment is most effective therapy, but no medical therapies have proven efficacy in RCTs https://t.co/ocQ5okBauq https://t.co/1DUm6FKfm8
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Melatonin doesnt work! 172 pts w/ unilateral TKA for Rx in DBRPCT trial of qhs 5 mg melatonin vs. 125 mg vit C placebo for 6 weeks. No differences in PSQI or other sleep measures @6wks. Poor sleep assoc w/ worse pt function and pain. https://t.co/b1gfnyB7Qw https://t.co/nT589CItIF
Dr. John Cush RheumNow ( View Tweet)
Guselkumab maintenance dose is 100 mg sc q8wks. GUIDE ph 3b trial treated 297 PSO super responders (PASI <3) w/ q8wk or extended q16wk GUS & demonstrated noninferiority of q16 wk dosing w/ disease control (91.9 vs 92.6%) https://t.co/31DPTmcVD2 https://t.co/qHMsyYCH4J
Dr. John Cush RheumNow ( View Tweet)
Review of Calcium Pyrophosphate Deposition Disease
Lancet Rheumatology has published a review of Calcium pyrophosphate deposition (CPPD) disease - a chronic inflammatory and degenerative crystal arthropathy that increases with aging.
https://t.co/svIGF3hM0Y https://t.co/17CNkOiGPB
Dr. John Cush RheumNow ( View Tweet)
NSAIDs Used Despite Contraindications
https://t.co/elhnmB3N52 https://t.co/VgIqKvkfVJ
Dr. John Cush RheumNow ( View Tweet)
Arthritis drugs may relieve long COVID lung symptoms
University of Virginia SOM researchers have identified a potential treatment for the respiratory symptoms of long COVID after discovering an unknown cause of the condition inside the lungs.
https://t.co/4gqVhzOEMg https://t.co/NEysSjRE8c
Dr. John Cush RheumNow ( View Tweet)