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INBUILD Study of 170 pts with autoimmune related ILD showed nintedanib signifi. slowed the rate of FVC decline in FVC decline over 52 wks (NIN -75.9 mL/yr vs PBO -178.6 mL/yr). AE's (mostly diarrhea) leading to D/C was NIN 17.1% vs PBO 10.2% https://t.co/CmbF5NQMfJ #BestOf2022
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Dr. John Cush RheumNow ( View Tweet)
AVOID THE WEEKEND! Study of high-impact rheumatology journals (Rheumatology, J Rheum, & Seminars A&R) shows higher risk of "desk rejections" by editor (avoiding peer review) for manuscripts submitted Saturday (OR 1.23) or Sunday (OR 1.13) https://t.co/rWIkiYgh8Y https://t.co/kPSJmfWSUl
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Dr. John Cush RheumNow ( View Tweet)
Good review of Diagnosis and Treatment of Pulmonary Sarcoidosis in JAMA.
- Lung progression (in only 10%) assoc w/ 12-18% 5yr mortality
- Sx Sarcoid w/ Lung: start Pred 20 to 40 mg/d for 2 -6 wks
- Steroid sparing w/ MTX, AZA or TNFi
https://t.co/aVnUXaj0sj https://t.co/JN142hlR6g
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Dr. John Cush RheumNow ( View Tweet)
Full read review of advances in bone biology leading to drug development (denosumab, romosuzumab, Burosumab), advances in Pagets and rickets and key regulatory molecules for bone remodeling, RANK, RANKL, OPG, & sclerostin https://t.co/1d6A6MsdbJ https://t.co/IuKEp1PQtr
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Dr. John Cush RheumNow ( View Tweet)
JAMA - Update/Review of Hemochromatosis Dx and Rx.
- 5 gene defects in hepcidin. 95% HFE & the C282Y variant
- 90% are asymptomatic
- Suspicion w/ arthralgias, LFTs, hepatomegaly, cardiomyopathy, 1st degr relative
- Untreated, 9% risk of cirrhosis
https://t.co/LWbIbLITK9 https://t.co/xDpA16K0tm
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Dr. John Cush RheumNow ( View Tweet)
#POTS
Postural orthostatic tachycardia syndrome - how it might link to other conditions
https://t.co/Ekn6KtOrC4
#Fibromyalgia #chronicillness #migraine #hypermobility #EDS https://t.co/JX1WDm2KKn
Dr Gurdeep Dulay gurdeep_dulay ( View Tweet)
$520 billion is the estimated cost of physical inactivity from 2020 to 2030 @LancetGH: https://t.co/JynmtU9oCF
Of the expected 500 million preventable cases of disease, 43% due to #depression and #anxiety.
#MentalHealthMatters @fiona_bull https://t.co/sVjkceNGiq
Scott Lear, PhD DrScottLear ( View Tweet)
Poncet’s disease: a reactive arthritis secondary to pulmonary M. tuberculosis
https://t.co/qMorRZBbi8
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Dr. John Cush RheumNow ( View Tweet)
COPA, a rare syndrome w polyarthritis, ILD, pulmonary hemorrhage, w excessive STING signaling. #RWCS2022
@RWCSmtg https://t.co/EUv8sMK8dx
Dr. John Cush RheumNow ( View Tweet)
New Hope for Hand Osteoarthritis
The drug talarozole – which increases retinoic acid – could be a promising new treatment for hand osteoarthritis.
https://t.co/jVMLiJLnch https://t.co/0nk8WA2k1S
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Dr. John Cush RheumNow ( View Tweet)
Lit review of MDA5 antibody-positive clinically amyopathic dermatomyositis w/ ILD - shows limited data from 15 studies, 388 pts, 1 RCT: ? best survival with high-dose steroids + immunosuppressive (CTX or CyA/tacrolimus). Refractory dz Rx w/PLEX, Tofa, RTX https://t.co/8yE4B3SfRg
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Dr. John Cush RheumNow ( View Tweet)
Lumbar spinal stenosis affects 103 million worldwide (11% of older adults in US). 1st line Rx is activity modification, analgesia, PT. Benefits of epidural steroids havent been established. Decompressive surgery only for selected pts w/ pain & limitation https://t.co/zye3p5j2Hn https://t.co/HzVGLT8Qgl
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Dr. John Cush RheumNow ( View Tweet)
Cancer Risk with Scleroderma
Spanish Scleroderma Registry examined a large cohort of systemic sclerosis (SSc) patients showing an increased cancer risk, especially breast, lung, hematologic and colorectal cancer.
https://t.co/S3EHajMF9q
#BestOf2022 https://t.co/kV772Jef4V
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Dr. John Cush RheumNow ( View Tweet)
#BestOf2022
Metanalysis of 7 studies shows that oral anticoagulants need not be discontinued for joint injections or aspiration. Only pts w/ hemorrhage after 5427 procedures, over 32-yrs. INR values of 3 bleeding cases was 1.9, 2.3, and 3.4. https://t.co/8e1zIhDTJt https://t.co/L4vIkWf2OL
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Dr. John Cush RheumNow ( View Tweet)
COVID-19 Vaccine Responses in Rheumatic Disease Patients
Nature Reviews Rheumatology features a review of three notable papers that address the impact of SARS-CoV-2 vaccination on people with inflammatory rheumatic disease.
https://t.co/R9UM3amPRR. https://t.co/WmHyVKdsxw
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Dr. John Cush RheumNow ( View Tweet)
Review of the Rheumatic causes of Pericarditis and their management. Causes: SLE, RA, MCTD, Myositis, EGPA, GPA, IgG4-rel Dz, FMF, TRAPS, CAPS, AOSD, JIA, Sarcoidosis, Kawasakis, GCA, Takayasu's https://t.co/MQmkUe4Yey https://t.co/FSfrznoeBe
Dr. John Cush RheumNow ( View Tweet)
Marginal Benefit with Diet and Exercise in Obese Knee Osteoarthritis Patients
The easiest intervention for knee osteoarthritis (diet and exercise) is also the most difficult for many patients; but do these work?
https://t.co/s4Gzmh2gGZ https://t.co/aZORTMtCvs
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Dr. John Cush RheumNow ( View Tweet)
#OA phenotypes by SF cell status
- Activated: hi T-cell, low mono–macrop-PMN activated; 70% improved
- Lymphoid: hi PMN, low lymph & mono, low activ, lower pain
- Myeloid: hi NK & mono, low T-cell & activat
- Aggressive: hi lymph/macr/NK/PMN;39%improve
-https://t.co/3DXPoDE5Pm https://t.co/VRJkscAm5a
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Dr. John Cush RheumNow ( View Tweet)
A&R: Climate Emergency and the Health of Our Patients
- A public health crisis that will affect Rheum pts
- climate factors can worsen Dz
- Pollution causes autoimmunity
- Climates worse effects on the vulnerable
- Advocacy solutions research are needed https://t.co/JJufiImhND
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Dr. John Cush RheumNow ( View Tweet)
Practical Guidance for the Clinical Rheumatologist in Unplanned Pregnancies
Women of reproductive age comprise an overwhelming majority of patients with rheumatic and musculoskeletal disease.
https://t.co/45ABQ0e2Qy https://t.co/dhLqzjf9uL
Links:
Dr. John Cush RheumNow ( View Tweet)
