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FDA issued draft guidance, which, if implemented, would remove requirement for a switching study for demonstrating biosimilar interchangeability. Citing research showing no additional safety concerns if pts switched from reference biologics to biosimilars https://t.co/MBvI4yxajW https://t.co/sEE654E2rl

FDA Issues Draft Guidance on Demonstrating Biosimilar Interchangeability

US News & World Report Top US Med Schools for Research Baylor Case Western Emory Hofstra Mayo Northwestern Ohio State UCLA UCSD UCSF U Cincinnati U Colorado U Pittsburgh UTSW Vanderbilt Yale https://t.co/VSEnBxWUF2 https://t.co/bGCBCD8npX

The Best Medical Schools for Research, Ranked

Lit review of ILD in anti-synthetase syndrome finds no conclusive evidence of effective treatment. 10 studies, 514 pts (68% female); Hi Res CT positive in 87% w/ 49% having NSIP pattern. 48% Jo-1+, 28% Ro52+. Low improvements w/ RTX (12%), CYC (17%). https://t.co/oJ0EMAE7d0 https://t.co/bDiA1h9hO7

Management and outcomes of interstitial lung disease associated with anti-synth…

Study of 136 referred LBP pts (71 w/ DDD, 38 DISH, 27 axSpA) found significant overlap of imaging features in all 3. SpA-like spine CR features were found in 1/4 of patients with DISH, and MRI BM edema found in 1/3 of those patients. https://t.co/dKIcuE3IGZ https://t.co/OITtOKEuNC

Significant overlap of inflammatory and degenerative features on imaging among …

Decline in Physician Trust During the COVID-19 Pandemic AMA reports that following the COVID-19 pandemic US adults trust in physicians and hospitals decreased, and was associated with lower odds of COVID vaccination. https://t.co/3XcMYcnzD3 https://t.co/yiIvOp1o5a

Decline in Physician Trust During the COVID-19 Pandemic | RheumNow

Frequency and Features of CPPD An international cohort study of patients with CPPD disease identifies both acute and chronic inflammatory phenotypes, each with distinctive clinical and imaging diagnostic features. https://t.co/3ox3YjVh5w https://t.co/1pB9f42a9M

Frequency and Features of CPPD | RheumNow

Ischemic Forearm Exercise Testing is used to Dx McArdles disease & the absence of elevated blood lactate levels during exercise in pts w/ myophosphorylase deficiency (McArdle disease) https://t.co/pNxl6qnnIR https://t.co/kOyk45Necd

RheumaKnowledgy » Ischemic Forearm Exercise Test

Study of 201 pts w/ chronic pain, prevalence of anxiety was 19%; higher in women (OR 7.94) longer pain (OR:1.3) & severe pain(OR:18.7) https://t.co/LD6pjH25qv https://t.co/mrlEo0UkEw

Prevalence and factors associated with generalized anxiety disorder among patie…

Medical literature review of suggests low vitamin D status is common in Rheumatic pts. & low vit D levels linked to loss of muscle strength, MSK pain, sarcopenia & falls (esp in IIM, PMR, SLE, RA, SSc) (BUT DOES REPLACING VITAMIN D FIX THESE PROBLEMS???) https://t.co/30IiKj7l4d https://t.co/ydU6FQMTi5

Vitamin D and Muscle Status in Inflammatory and Autoimmune Rheumatic Diseases: …

Calcinosis cutis affects 40% of SSc pts w/ significant morbidity. Assoc w/ Long Dz duration, vascular dysfunction, & osteoporosis. Dx by radiography. Surgical treatment is most effective therapy, but no medical therapies have proven efficacy in RCTs https://t.co/ocQ5okBauq https://t.co/1DUm6FKfm8

Calcinosis in systemic sclerosis : Current Opinion in Rheumatology

Melatonin doesnt work! 172 pts w/ unilateral TKA for Rx in DBRPCT trial of qhs 5 mg melatonin vs. 125 mg vit C placebo for 6 weeks. No differences in PSQI or other sleep measures @6wks. Poor sleep assoc w/ worse pt function and pain. https://t.co/b1gfnyB7Qw https://t.co/nT589CItIF

The John N. Insall Award: Does Melatonin Improve Subjective Sleep Quality After…

Arthritis drugs may relieve long COVID lung symptoms University of Virginia SOM researchers have identified a potential treatment for the respiratory symptoms of long COVID after discovering an unknown cause of the condition inside the lungs. https://t.co/4gqVhzOEMg https://t.co/NEysSjRE8c

Arthritis drugs may relieve long COVID lung symptoms | RheumNow

Full read review of tendinopathies - triggers (mechanical, intrinsic, extrinsic), biology, biomechanics & repair. Despite multivariable biologic disruptions, tendinopathies is mostly restricted to symptomatic therapy. https://t.co/h2D3fbUNVO https://t.co/2rmw6E0F6Z

Spectrum of Tendon Pathologies: Triggers, Trails and End-State

CHECK: a prospective cohort study shows that Femoroacetabular impingement syndrome in is strongly associated with the development of radiographic hip OA (RHOA) within 10-yrs (OR 6.85 for incident RHOA and OR 47.82 for end-stage RHOA) https://t.co/Kt0bsIdpnS https://t.co/mSGRbQV4vI

Femoroacetabular impingement syndrome in middle-aged individuals is strongly as…

Elder adult Cohort study of 2413 women & 792 men w/ hip BMD-defined osteoporosis based on CT scans, shows 30% of women & 34% of men had hip Fx. Rx w/ alendronate (34%F; 24% M) signif lowered Fx rates (aOR 0.26 and 0.21, respectively) = no sex difference https://t.co/briuZAYVKx https://t.co/xrZ12TmMvM

Osteoporosis treatment prevents hip fracture similarly in both sexes: the FOCUS…

New Classification Criteria for Juvenile Axial Spondyloarthritis An expert panel has published new and validated classification criteria for axial disease in children with juvenile spondyloarthritis (SpA; AxJSpA). https://t.co/kxtHlEk5XG https://t.co/jKAp9W5Di1

New Classification Criteria for Juvenile Axial Spondyloarthritis | RheumNow

In the UK, estimated cost of hardardous NSAID use is £31.43million (pounds) (£9.28m to £67.11m) over 10 yrs. High risk = Elderly >65y without gastroprotection, pts on anticoagulants; & Pts w/ heart failure, chronic kidney Dz , or Hx of peptic ulcer. https://t.co/bPXnQbQnNV https://t.co/aDLGHjLmhB

Estimating the economic effect of harm associated with high risk prescribing of…

Polypharmacy Doubled in 20 Years. Polypharmacy (5+ Rx last month) went from 24% in 2000 to > 40% in 2020 https://t.co/2czI4DxlVm https://t.co/VAZkbxKrJP

Study: Polypharmacy Nearly Doubled in 20 Years Among Older Adults in US

Location, Location, Location (7.26.2024) Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow. Location matters; Geo-rheumatology? https://t.co/I81qpckOQG https://t.co/cyu64ThPkN

Location, Location, Location (7.26.2024) | RheumNow

Whats it like to be a Rheum? AMA shadows 11 yr rheumatologist Dr. Amish Dave - typical day, challenging aspects, burnout, lifestyle, skills, insights and med student advice - Thanks Dr. Dave!! https://t.co/AIfWwb4HpG https://t.co/EvFVAeqWfK

What it's like in rheumatology: Shadowing Dr. Amish J. Dave

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