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NIH has granted $4.7 million to fund OHSU/UAB/UNC scientists to develop Novel 2-Pyrimidone (SRI-42718) Chikungunya antiviral drug. 2022: >360,000 Chikungunya cases w/ 77 deaths (mostly Brazil, India Guatemala) w/ 13 acquired in U.S. https://t.co/5ospHoFBBQ https://t.co/E1WKvdhaUO
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The Best Prescription
The craziest question that you can ask any doctor is “what is your best therapy for __?”. Crazy, because there are exponential answers, with factored layers that make each decision unique to that doctor.
https://t.co/iX8T6NSD00 https://t.co/8VUPbDjXzr
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Rheumatology was one of 6 specialties to fill > 95% during fellowship Match in 2022. Rheum filled 96.9% of 127 programs & 97.8% of 265 spots with 40 US foreign applicants (15.1%), 123 MD grads (46.4%), 66 foreign (24.9%), & 36 DO grads (13.6%) https://t.co/EqfCbkxEbS https://t.co/c12m5FrAll
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Syphilis has risen 5 fold since 2001, 38 992 cases, or 11.9 per 100K in 2019. The USPSTF recommends screening in persons at increased risk. Most labs rec “reverse sequencing” w/ automated treponemal test (eg EIA), instead of RPR or VDRL1st https://t.co/vL2rkP2rO1 https://t.co/FAcijAl8LB
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Systematic review of MSK findings in patients with acute lymphoblastic leukemia finds 29 pts with peripheral arthritis (7), axial manifestations (17), and osteolytic lesions (21 pts) & Vertebral Fx (4) Hypercalcemia in 9 cases. https://t.co/GJXoqhOjNG https://t.co/YHS09E4a0U
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Joint hypermobility linked to depression & anxiety? Longitudinal Study of 6105 kids at age 14 yrs: 19% had generalised joint hypermobility (more in F) *+& assoc w/ depression (OR: 3.53), anxiety (3.14) at age 18 https://t.co/9NrEfwt4L5 https://t.co/JrM2JKUuJ0
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3388 pts in J Hopkins Scleroderma study found 29% w/ calcinosis (13.5% these w/ heavy burden calcinosis/HBC). Calcinosis assoc w/ diffuse SSc, disease severity (PH, ILD, CVD, GI, renal crisis, myopathy)(OR 2.9- 6.9) & PM/Scl Abs (OR 17.31) https://t.co/ksdPcH9W0O https://t.co/OvI9wytf5H
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Top 10 Pharma Revenues 2021:
1 J&J $93.77 billion (USD)
2 Pfizer $81.29 B
3 Roche $68.7 B
4 AbbVie S$56.2 B
5 Novartis $51.63 B
6 Merck $48.7 B
7 BMS $46.4 B
8 GSK $43.57 B
9. Sanofi $44.67 B
10. AstraZeneca $37.47 B
https://t.co/ptFAyk4S5S https://t.co/cCtPboI53x
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Goofy or Novel: "How gravity may cause irritable bowel syndrome". A hypothesis, published in the American Journal of Gastroenterology, describes how the intestines, spine, heart, nerves and brain evolved to manage gravity. https://t.co/lLyAkruyyy? https://t.co/TJH8Du8rm6
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Multi-ancestry analysis reveals novel genetic loci associated with OA
https://t.co/AIo3il8uHP https://t.co/nXGtOCCZsA
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Systematic review comparing MIS-C and Kawasaki: 14 studies, 2928 pts; major differences- KD pts were younger; MIS-C had more Pulm, GI, Shock, more cardiac (LV, valvular pericarditis, myocarditis), but less coronary lesions & conjunctivitis https://t.co/bcCRh5HxL7 https://t.co/qLvfCYwx9u
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NRMP Results for rheumatology 2022 :
- Adult Rheum: 97.8% of 272 fellow positions filled (41% US grads) (371 applied)
- Pediatric Rheum: 69.2% of 39 positions filled (54% US grads) (29 applied)
WE NEED MORE ADULT PROGRAMS AND MORE INTEREST IN PEDI RHEUM https://t.co/sqcIXxWrxx https://t.co/9xeUQeAuDD
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Follow us on LinkedIn too!
https://t.co/iylzzYRVAB https://t.co/7rKQShIzs5
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Recent CDC/MMWR report shows Paxlovid x 5days (including those w/ prior COVID or vaccination), had a 51% lower hospitalization rate within 30 days after diagnosis than those not prescribed Paxlovid. Use it irrespective of vaccination status https://t.co/CBc1VBSDFR https://t.co/EC8QGaFrb3
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Impressive free read and review of Neutrophils and Netosis in Autoimmune and Autoinflammatory disorders (Nature Reviews) from Kapland & Wigerblad at the NIH. https://t.co/w4cIwcQMkt https://t.co/ReA9xM2X4j
Dr. John Cush RheumNow ( View Tweet)
Artificial Intelligence in Detecting Sacroiliitis
Dr. Akhil Sood ( @AkhilSoodMD) discusses Abstract 0383 at #ACR22.
https://t.co/U52eAFOePr https://t.co/8WcecoF5Sr
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TIME Mag - "Why Masks Still Matter". 1) COVID is still out there; 2) Influenza on the rise. Authors write "With limited yet mixed data, we would be wise to ...err on the side of masking in high risk, indoor crowded public settings..." https://t.co/l8jiTwAdZz https://t.co/0QUKJDOhjs
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1st quarter of 2022, only 29% of Medicaid and Medicare users had at least one telehealth visit - down from 46% in all of 2021. (Data from Centers for Medicare & Medicaid Services) https://t.co/RCYjlJOPS3
Dr. John Cush RheumNow ( View Tweet)
Medication adherence is a problem
I assume that when I prescribe something for patients that they fill the prescription (right away) and take it as planned…or is this a pipe dream?
@Janetbirdope weighs in.
https://t.co/qj3insA6fL https://t.co/yV0xlvdNZu
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SLE, Sex and STDs
Once in a while, I find an abstract at the American College of Rheumatology meeting that can potentially save lives and be implemented in practice now.
Dr. Dao ( @KDAO2011) discusses abstract #0939 presented at #ACR22.
https://t.co/0DtAgzB41G https://t.co/O1z7J0O4c6
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Dr. John Cush RheumNow ( View Tweet)
