Tocilizumab in Pregnancy

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Tocilizumab is currently listed as a Category "C" pregnancy risk based on limited pre-clinical (animal) data that was negative.

Cancer Risk Lower with TNF inhibitors in Rheumatoid Arthritis

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Since the introduction of TNF inhibitors nearly 20 years ago, concerns over a potential associated cancer risk have abounded. The recent ACR RA treatment guidelines have addressed this recently, stating that patients with any solid tumor cancer or risk thereof should be treated as if they ha

Biologics and Fatigue in Rheumatoid Arthritis

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Researchers from Bristol, UK have published a Cochrane review studying the effects of biologic therapies on fatigue.

Hyperuricemia Increases Risk of Diabetes, Death and CV Disorders in Hypertensive Patients

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While hyperuricemia is linked to gout and many of the elements that make up the metabolic syndrome, it's not so clear that hyperuricemia is an independant risk factor for hypertension, diabetes, cardiovascular outcomes, etc.

Family History and Rheumatoid Arthritis

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AS Diagnosis Linked to CVD Risk

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Prevalent patients with ankylosing spondylitis (AS) face a 30–50% increased risk of acute coronary, cerebrovascular, and thromboembolic events compared with the general population.

RheumNow Week in Review – 24 June 2016

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Dr. Cush reviews highlights published this week at RheumNow.com.

Infection Risk Increased in Giant Cell Arteritis

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French researchers recruited 486 patients with giant cell arteritis (GCA) from over 40 centers throughout France, and compared their outcomes to age and sex matched individuals randomly selected from the general population. Both groups were followed for 5 years and assessed for the risk of serious infections.

Hypogonadism Ups the Risk of Autoimmunity

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In a variety of models, testosterone has been shown to be immunosuppressive and deficiency of testosterone has been linked with autoimmune disease and increases in C-reactive protein (CRP), tumor necrosis factor, and interleukin-6 (IL-6).

Predictors of Progression in Early Inflammatory Polyarthritis

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A substantial, but unclear, percentage of patients presenting with new onset inflammatory polyarthritis (IP) will spontaneously remit, while others may persist and develop rheumatoid arthritis (RA).

New EULAR Guidelines on Behçet's

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At the EULAR 2016 meeting, new EULAR recommendations for the management of Behçet's disease (BD) were presented.

A $20 Drug Company Meal Yields 2-5 Times More Prescriptions

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Accepting a single pharmaceutical industry-sponsored meal was associated with higher rates of prescribing certain drugs to Medicare patients by physicians, with more, and costlier, meals associated with greater increases in prescribing, according to an article published online by JAMA Internal Me

EULAR 2016 Drug Safety Report

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The EULAR Annual European Congress of Rheumatology meeting was held in London from June 8-11, 2016 and was well attended by thousands. This year’s meeting had over 2,000 poster displays, and the EULAR 2016 Congress presented new recommendations on the management of rheumatoid arthritis, spondyloarthritis, and fibromyalgia.

Steroid Use in Early Rheumatoid Arthritis Associated with Fractures

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The impact of systemic glucocorticoid exposure on fracture risk among new-onset rheumatoid arthritis (RA) was studied using administrative claims data detailing the treatments and outcomes of 42,127 newly diagnosed RA patients (between 2005-2012).

Pregnancy Complications in Primary Sjogren's

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Sjogren's syndrome is a highly prevalent disorder, affecting women ten times more frequently than men.  Although the typical onset follows menopause, a minority of women may develop primary Sjogren’s syndrome (pSS) during child-bearing years.

RheumNow Week in Review – 17 June 2016

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Dr. Jack Cush reviews the news, reports and highlights from EULAR and the last 2 weeks from RheumNow.com.

European Registries Show No Melanoma Risk with Biologics

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The combined analysis of 130,315 rheumatoid arthritis patients from 11 European registries did not reveal an association between invasive (malignant) melanoma and the use of biologic therapies.

Arthritis and Suicide Linked with Childhood Adversities

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Men and women with arthritis have nearly a two-fold higher prevalence of lifetime suicide attempts than those without arthritis, according to a recent study from the University of Toronto.

Dramatic Results for Interferon Blocker in SLE

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Blocking the type 1 interferon receptor with the monoclonal antibody anifrolumab shows promise as a treatment for moderate-to-severe systemic lupus erythematosus (SLE), according to a phase IIb study presented here.