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Autoimmune Disease Clustering at ENDO 2019

d Jack Cush, MD

A twin registry database study was presented at the Endocrine Society's annual meeting (ENDO 2019) in New Orleans, showed that that having autoimmune disease significantly increases the risk of other autoimmune disorders and that autoimmune clustering was highest in Addison's disease and vit

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Resistant Hypertension Common in SLE

d RheumNow

Rates of resistant hypertension were doubled among patients with systemic lupus erythematosus (SLE), significantly increasing their mortality risks, a retrospective single-center study found.

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Improved Mortality Trends in Lupus Nephritis

d Jack Cush, MD

The mortality rate from end- stage renal disease (ESRD) in lupus nephritis (LN) patients has significantly decreased in the last decade.

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Risky Painkillers Commonly Prescribed for Osteoarthritis

d RheumNow

Published guidelines warn that treating osteoarthritis (OA) with opioids and benzodiazepines can boost patients' risk of falling.

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Catastrophic antiphospholipid syndrome 500pts: Most had a precipitating factor (65%), half infections. Organ involvement - kidneys (73%), lungs (60%), brain (56%), heart (50%), skin (47%). LAC, IgG ACL & IgG β2-glycprot Abs were most common. Mortality=37% https://t.co/puLeBn0kBu

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After either RTX or CTX induction, 102 pts w/ ANCA-associated vasculitis were give maintenance w/ azathioprine plus belimumab or placebo. Belimumab did not reduce the flare rate (HR=1.07;) or relapse (HR=0.88) (NS) in these patients https://t.co/5EgdzRRXq8

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Lab testing for disorders of the ascending aorta. Dr Philip Seo. #RNL2019 https://t.co/asobKYdRma
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#RNL2019 Dr Carol Langford’s approach to Rx if GPA https://t.co/khy0h6sMA4
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Dr Phil Conaghan on the similarity between OA and PsA #RNL2019 https://t.co/za9YDAWilE
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Coal miners at higher risk for any arthritis (HR 2.3) and rheumatoid arthritis (HR 3.6) https://t.co/OKx9LiADWw

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serum soluble programmed cell death protein 1 (sPD-1)shown to correlate w/ BVAS activity in 59 pts w/ ANCA-associated vasculitis (AAV). sPD-1 was correlated with hemoglobin and serum albumin, but not ESR or CRP. https://t.co/GOShh8Kwb2

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Dr. John Cush RheumNow ( View Tweet)

Prevalence of gout continues to rise. NHANES data say prevalence of gout is 9.2 million inUS adults (2015-2016) (5.9 mill men; 3.3 mil women); hyperuricemia prevalences is 20.0%. ULT use in gout was 33% between 2007-2014. https://t.co/nDEJM7gTGA

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A review of OP Guidelines, published in Osteoporosis International, shows only 27 of the 70 guidelines patient Beliefs, Values or Perceptions. https://t.co/zGoX2aaxdP

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Dr. John Cush RheumNow ( View Tweet)

AAOS meeting presentation of 114,698 TKR pts shows younger pts (age <40) have a 3 fold greater risk of early mechanical complications & are 63% more likely to be rehospitalized w/in 90D. Younger have more obesity, DM, inflamm arthritis, ACL surgery https://t.co/DoePD5GXl9

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The risk of acute coronary syndromes in inflammatory myositis patients is doubled, especially in the first year (vs general population) and in older individuals. (HR 2.4; 1.8-3.2) - 7% IIM vs 3.3% in controls at 5 yrs. https://t.co/lCWGfm81EN

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QD Clinic - Goldilocks and Osteoarthritis | RheumNow - Finding the Right Ddose for the Right Patient? https://t.co/SMmVYDxPeX

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Dr. John Cush RheumNow ( View Tweet)

FREE Online viewing of RheumNow Live - Friday 3/22 at 1pm EST. 2 hr discussion blocks on RA, PsA, AS, SLE, Vasculitis. 10 "TED" talks interspersed from Cush, Calabrese, Van Vollenhoven, Schett, Matteson, Wolfe, Oransky,etc. SEE YOU THERE OR REGISTER HERE https://t.co/lbrJ0Dp1Hb

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Rheumatologists are the happiest specialists! https://t.co/C6aaHWq7qf @ACRheum Choose Rheumatology and Be Happy! @alhkim

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Jeff Sparks jeffsparks ( View Tweet)

Study of 151,305 pts from Clinical Practice Research Datalink, shows that THR/TKR patients exposed to statins for 1-5 years had ~25% reduced risk of arthroplasty revision (HR 0.74 (0.62, 0.88)). https://t.co/AQhKHuAwkD

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Pain signaling via NMDA receptors in the brain can be treated with drugs that block NMDA receptors (ketamine, methadone, memantine, amantadine, dextromethorphan). Metanalysis of memantine (15 studies) shows little benefit. https://t.co/72yfYzDXhV

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Dr. John Cush RheumNow ( View Tweet)

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