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Increasing Risk of Septic Arthritis with Age
A retrospective population-based study from New Zealand examined the epidemiology, clinical features, and microbiology of adult native joint septic arthritis.
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Economic Burden of ANCA-Associated Vasculitis in the USA
To assess the prevalence and magnitude of healthcare costs associated with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) in the USA, researchers analyzed adminstrative data from Truven Health MarketScan Commercial and Medicare Supplemental databases.
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Wine, Lupus, Pregnancy and Biosimilars: October 2015 -Top Social Media News
In October 2015, RheumNow published 76 tweets about impactful news, research and teaching points that impact the rheumatology community. In October, RN had a reach (impressions) of 49,500, 79 mentions, and over 2000 visits to RheumNow.com to check out what we publish.
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More Adverse Events with Off-Label Drug Use
Off-label use of prescription drugs was associated with adverse drug events in a study of patients in Canada, according to an article published online by JAMA Internal Medicine.
Repeat Skin Cancer Risk with Methotrexate and Biologics
Using Medicare claims data, a retrospective cohort study analyzed the risk of a second non-melanomatous skin cancer (NMSC) in 9460 individuals (6841 with RA and 2788 with IBD).
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DSB: Drug Shortages - October 2015
Each month, RheumNow reviews compiled listings of drug shortages germane to the practive of rheumatology using several sources. If you have suggestions or information about specific drug shortages or drug safety issues please email us at info@rheumnow.
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No Correlation Between Urate Crystal Identification and Cardiovascular Risk
A Danish cohort study examined patients with hyperuricemia and compared outcomes in those proven to have urate crystal deposition (317 patients) and matched 1:1 to patients without urate crystals.
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Study Backs CellCept for ILD in Scleroderma
MONTREAL -- An immunosuppressive drug was as effective as a standard agent for interstitial lung disease (ILD) associated with scleroderma, a researcher said.
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ANCA Levels Predict Relapse in ANCA-Associated Vasculitis
A team of Japanese investigators examine 126 patients with ANCA-associated renal vasculitis to see if ANCA levels would predict disease relapse.
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Downward Trends in US Mortality Statistics
Using death certificate data from US National Vital Statistics System of the National Center for Health Statistics (NCHS) and the Centers for Disease Control and Prevention, JAMA reports a downward trend in death rates in the USA from 1969 - 2013).
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Obamacare Deficient in Rheumatologists, Other Specialists
The October 27 issue of JAMA reports a study of federal marketplace insurance plans shows roughly 15 percent completely lacked in-network physicians for at least one specialty, a practice found among multiple states and issuers.
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High Level Skin Responses Seen with Inhibitor of IL-23p19 in Psoriasis
Rheumatology News reports the results of a novel trial presented at the European Academy of Dermatology and Venereology meeting in Copenhagen.
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FDA Panel Votes 10-4 to Approve Lesinurad for the Treatment of Hyperuricemia/Gout
Despite concerns over safety, the FDA Arthritis Advisory Committee voted favorably to approve lesinurad (LES) at a meeting held Friday, October 23, 2015. Overall, panel members felt the potential benefits of LES outweighed the safety concerns reviewed by the FDA presenters.
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Vertebral Fractures in 10% of Spondyloarthritis Patients
Vertebral fractures are not uncommon in patients with ankylosing spondylitis and spondyloarthritis.
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IV Cyclophosphamide Equal to Mycophenolate in Lupus Nephritis
A comparison of mycophenolate mofetil (MMF) and low-dose cyclophosphamide IV (CYC) in the treatment of lupus nephritis (LN) was examined in 173 patients with class III, IV, or V LN.
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Increasing Placebo Responses in the USA
A recent analysis of randomized clincal trials (RCT) for the treatment of neuropathic pain has shown in increase in placebo responses. (Citation source http://buff.ly/1LL8yAi)
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MMP-3 Levels Predict Radiographic Progression in RA
Continuously elevated serum matrix metalloproteinase-3 (MMP-3) for 3-6 months predicted 1-year radiographic progression in rheumatoid arthritis (RA), according to a small prospective cohort study in Arthritis Researc
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U.S. Pays 10 Times More for Prescription Drugs than Other Countries
Prescription drugs may cost up to 10 times more in the United States than they do in other countries, according to a 2013 Comparative Price Report was released last month by the International Federation of Health Plans (IFHP).
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Adalimumab Induction in Early RA Yields Erosive Benefits in the OPERA Study
A number of studies have shown that the treat-to-target approach is effective in achieving clinical remission - the ultimate therapeutic goal in patients with early RA.
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FDA Reviews the Safety of Lesinurad in Gout
Lesinurad is a novel URAT-1 inhibitor being developed as a urate-lowering therapy for gout by Astra-Zeneca.
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