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Stopping Biologics Before Joint Surgery: Is Earlier Better?

d RheumNow

Withholding intravenous abatacept (Orencia) for longer than a month before hip or knee arthroplasty among patients with rheumatoid arthritis (RA) did not lower the risk for postoperative infection, a retrospective claims-based analysis found.

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Mortality and Hospitalization with Pulmonary Hypertension in Systemic Sclerosis

d Jack Cush, MD

PHAROS is a prospective cohort studying the natural history of pulmonary hypertension (PH) in systemic sclerosis (SSc). They have shown that risk factors for poor outcomes in this cohort included male sex, DLCO < 50%, exercise oxygen desaturation, and pericardial effusions. 

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Noninfectious Proximal Aortitis Needs Serial Follow-ups

d Jack Cush, MD

A Cleveland Clinic review of patients undergoing thoracic aortic surgery (1996‐2012) identified 196 patients with histopathology‐proven non‐infectious aortitis.

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Dr Aryeh Fischer on risk factors for ILD. #RWCS2019 https://t.co/a86BBgxEMm
Dr. John Cush RheumNow ( View Tweet)
Dr Aryeh Fischer on ILD increasing #RWCS2019 https://t.co/euvky7H3Bs
Dr. John Cush RheumNow ( View Tweet)
Good morning from #RWCS2019! Year in Review #1: HCQ doesn't work for hand OA, so stop using it! Jack Cush @RheumNow has talked about this multiple times on his podcast. I'd say the same for Sjogrens (see my podcast on JOQUER trial), but that's more controversial. https://t.co/fmb2bfVhg0
Mike Putman EBRheum ( View Tweet)
Analysis of a large Pediatric hospital database and 5679 SLE admissions shows that 12.4% had Pericardial Effusion (PCE) at entry. PCE was assoc w/ 2.5 higherrisk of In-hospital mortality(p 0.027) and 1.5 time more 30Day readmissions (p 0.001). https://t.co/XS6FEGfdH5

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Dr. John Cush RheumNow ( View Tweet)

927 Lupus registry study shows that use of combined hormonal contraceptives was low (8%) and nearly half (55%) took place in the setting of possible contraindication such as aPL (52%), HTN (34%), migraine with aura (22%). More study and info is needed https://t.co/yTCKbRTp2m

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Dr. John Cush RheumNow ( View Tweet)

RCT of 559 patients undergoing hip replacement shows that postoperative use of paracetamol plus ibuprofen or ibuprofen alone significantly reduced morphine consumption. https://t.co/JbnkvBzibC

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Dr. John Cush RheumNow ( View Tweet)

JBMR reports that women with single & multiple fractures (hip, spine, ribs) strongly negatively impacts the HRQL of older people over a prolonged period, and that they may not recover their prefracture QOL. https://t.co/1udPUiyCc0

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Dr. John Cush RheumNow ( View Tweet)

Small study of 25 pregnancies in RA compared those who continued biologics till conception vs those who stopped before conception. Continuing biologics till conception lead to a significantly shorter time to pregnancy. https://t.co/NjhMDbQVux

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Dr. John Cush RheumNow ( View Tweet)

Dr Anne Stevens at RWCS. Many dysregulated paths contribute to fibrosis in disease. #RWCS2019 https://t.co/dCXjoge0yL
Dr. John Cush RheumNow ( View Tweet)
Dr Anne Stevens at RWCS. Pathways to Fibrosis. #RWCS2019 https://t.co/gTYWWrxY81
Dr. John Cush RheumNow ( View Tweet)
Dr Paul Emery at RWCS. RA without xray erosions- 45% have ultrasound erosions #RWCS2019 https://t.co/MlOUaMTgfd
Dr. John Cush RheumNow ( View Tweet)
Dr Paul Emery at RWCS. #RWCS2019 https://t.co/MFqjLVzpDa
Dr. John Cush RheumNow ( View Tweet)
Dr Aretha Fischer on how to tx ILD. #RWCS2019 https://t.co/vZhX25NhFF
Dr. John Cush RheumNow ( View Tweet)
Dr Aretha Fischer on ILD. #RWCS2019 https://t.co/YAyXapxr8C
Dr. John Cush RheumNow ( View Tweet)
The Best Rheums go to the Best Meetings - RHEUMNOW LIVE - March 22-24 2019 Great Venue =Fort Worth. Short Lectures, interactive sessions, Q&A panels, TED (like) Talks, digital, streaming and much more. You dont want to miss this meeting! https://t.co/5TVg0Frsbf

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Dr. John Cush RheumNow ( View Tweet)

Genetic study using Mendelian randomization methods in a large UK biobank shows that whereas serum Uric acid has no association with eGFR level nor CKD risk, sUA does show a significant risk of #Gout. https://t.co/YRiVuOKof4

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Dr. John Cush RheumNow ( View Tweet)

In a mouse model of Pso/SpA/IBD the administration of IL-23 was associated with specific microbiome changes that correlated with disease activity https://t.co/wWjVNkvOfz

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Dr. John Cush RheumNow ( View Tweet)

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