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RA erosions bone ACR

AI Identifies and Predicts Radiographic Change in Rheumatoid Arthritis

ACR

The American College of Rheumatology's (ACR) has published a preview of new research from ACR Convergence 2023 showing that AI and a deep learning system could accurately identify and predict joint space narrowing and erosions in hand radiographs of patients with rheumatoid arthritis (RA).

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X-Rays Questioned for Diagnosing Early Rheumatoid Arthritis

MedPage Today

Routine hand and foot radiographs in more than 700 patients being evaluated for rheumatoid arthritis (RA) made almost no difference in diagnosing the condition nor in predicting its course, Dutch researchers said.

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Incidence, Microbiological Studies, and Factors Associated With Prosthetic Joint Infection After Total Knee Arthroplasty

Jack Cush, MD

A study of nearly 80,000 US veterans who underwent primary knee joint arthroplasty (TKA) showed  the incidence of prosthetic joint infection (PJI) was highest in the first 3 months and remained elevated through 12 months compared with 12 months or more after surgery.

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Anakinra Effective in Systemic JIA, Irrespective of HLA-DRB1 and IL1RN Variants

Jack Cush, MD

A prospective study of first line use anakinra in systemic juvenile idiopathic arthritis (sJIA) proved to be effective and without potentially allergic lung reactions.

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Late Should Not Be Less (11.3.2023)

Jack Cush, MD

Dr. Jack Cush reviews the news, journal reports and regulatory approvals from the past week on RheumNow.com.

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MANKIA VIDEO BLOG

PMR and Palindromic Rheumatism Similarities

Kulveer Mankia

I'd like to discuss the similarities between polymyalgia rheumatica and palindromic rheumatism. And in doing that, highlight how these similarities help us understand the relationship between polymyalgia rheumatica and rheumatoid arthritis. Perhaps not everybody watching this will be very familiar with palindromic rheumatism. It is considered uncommon, but every rheumatologist sees it in their practice.

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Patients Don't Read Textbooks RA patient unresponsive to biologics, now has enthesitis; what to do? QD Clinics are sponsored by RheumNows Coverage of #ACR23 live from San Diego https://t.co/hlacYXm0Nh https://t.co/52Xy3E8kXi

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Dr. John Cush RheumNow ( View Tweet)
Biologics, #RA and Risk of skin CA (NMSC) is complex. - RA alone is a risk for NMSC 49K study of ABA & NMSC ; - In RCTs, risk same w/ ABA & PBO - Registries & Claims data: equal w/ ABA, csDMARDs. b/tsDMARDs - Pooled obs data shows slight ABA risk https://t.co/tp6F0cJWug https://t.co/u6UdAUZqoc

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Dr. John Cush RheumNow ( View Tweet)
UK biobank population study shows a bidirectional assoc. betw RA & ILD (each @ incr risk for the other). In non-COPD pts, RA increased risk of COPD (HR=1.65) & in non-RA pts, COPD had a higher risk of future RA (HR=1.67). Both mediated by inflammation https://t.co/imn4ddV7CS https://t.co/UZaszEnCqt

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Dr. John Cush RheumNow ( View Tweet)
New download available, titled "Dealing with Infections" https://t.co/hsOuJoFokg https://t.co/G3MZ9BQo0X

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Dr. John Cush RheumNow ( View Tweet)
Oral Surveillance Study Alters Practice at VA Safety risks found in a postmarketing trial with the JAKi tofacitinib (Xeljanz) appear to have influenced prescribing patterns across the class for RA patients in the VA health system, researchers found. https://t.co/6WktHCkrI1 https://t.co/8wpAeLsBbw

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Dr. John Cush RheumNow ( View Tweet)
Metanalysis of 26 studies (2252) pts w/ HBsAg-/HBcAb+ RA treated with b/tsDMARDs, shows the pooled HBV reactivation rate was 2.0% HBV reactivation higher w/ RTX (9%), ABA (6%), JAKi (1%); none w/ IL-6i or TNF-i More reactivation if pt is HBsAb- (OR=4.56) https://t.co/V60nkUSpjj https://t.co/jnZKnY0Zuk

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Dr. John Cush RheumNow ( View Tweet)
Study of LATE-onset RA (>65y), shows DMARD initiation is low in LORA; despite current clinical practice guidelines recommending early aggressive Rx. Among 3,373 LORA pts (age77 yrs), only 29% initiated on a DMARD (28.9%). https://t.co/bWHaiiSMVl https://t.co/NmrDeG8UPW

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Dr. John Cush RheumNow ( View Tweet)
256 Early RA pt cohort followed 10yrs showed SDAI sustained remission(n 48) had less 10 yr Xray progression (mTSS 4.06), vs sustained LDA (14.6) or MDA/HDA (21.04). Sustained remission pts were younger, lower HAQ & mTSS scores; less need for GC & bDMARDs https://t.co/92L7RTCx82 https://t.co/4uZBydcfRM

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Dr. John Cush RheumNow ( View Tweet)
Analysis of the NOR-DMARD registry and Vienna #RA cohorts provided novel definitions for an RA flare, requiring an increase of -4.7 on the SDAI or -4.5 on the CDAI Flare definitions correlated with functional and Xray outcomes. https://t.co/f2G2nYyyWT https://t.co/JczDZa9oUf

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Dr. John Cush RheumNow ( View Tweet)
RheumNow Live registration is NOW OPEN! Early bird pricing through 11/30/2023. Register today! https://t.co/7OsdPYWukv https://t.co/QoCxR04bJD

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Dr. John Cush RheumNow ( View Tweet)
Hong Kong study of 12233 RA pts followed 8.7 yrs, and 7% developed MACE. Daily Pred ≥5 mg signif increased the MACE risk (HR ~ 2), dose-dependent fashion; YET Pred <5 mg/d was not associated with MACE risk (vs No GC) https://t.co/26peaYp4kQ https://t.co/ooax9iTZYo

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Dr. John Cush RheumNow ( View Tweet)
Innovative, full-read, state-of-the-art article on IMAGING in INFLAMMATORY ARTHRITIS & its future role in precision medicine. "Imaging is poised to become an invaluable tool in precision medicine..". HR-pQCT, 3T or 7T MRI, FAPI PET–CT, CEUS, FOI, etc https://t.co/fGQVEOkea9 https://t.co/XyvtZj85Hk

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IL-2 receptor (sCD25) levels as a biomarker of RA-ILD? Study of 294 RA pts (56 w/ ILD) & 58 healthy controls (HCs) (ILD confirmed by HRCT). sCD25 sensitivity 51% & specificity 77%,; it elevated in RA-ILD subtypes (UIP, NSIP); but didnt correlate w/ HRCT https://t.co/1gJ635tu8a https://t.co/aYamfJwJi2

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Dr. John Cush RheumNow ( View Tweet)
Canadian survey of 620 pts w/ chronic & debilitating arthritis, shows the majority (76%) are free of psychiatric disorders (76%) & in good (complete) mental health (56%); fostered by having a confidant, & being without insomnia, depression/anxiety https://t.co/6agOYCmnit https://t.co/IBKCjUo0DQ

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Dr. John Cush RheumNow ( View Tweet)
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