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Humira Clobbers Biosimilars in Battle for Part D Coverage
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Medpage Today
Just about every Medicare Part D prescription drug plan on offer this year covers the original version of adalimumab (Humira), whereas only about half will pay for any of the several biosimilar versions currently approved, researchers found.
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Is Cannabis Safe? (6.7.2024)
Dr. Jack Cush reviews FDA approval, news and journal articles -- and it’s the week before EULAR 2024 in Vienna!!
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Cannabis Use is Common, But is it Safe?
Two current JAMA reports suggest that cannabis use is not only common, but that if heavily used may increase mortality rates.
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Cannabis Use is Common, But is it Safe?
Two current JAMA reports suggest that cannabis use is not only common, but that if heavily used may increase mortality rates.
https://t.co/ue9IRcbkCm https://t.co/IiG1RsIJiS
Dr. John Cush RheumNow ( View Tweet)
Is there an Increasing Risk for Tick-Borne Disease ? JAMA article purports this to be so..... I think not - not unless you live in endemic areas. Other wise these still are rare, rare or misdiagnosis based on serologic inaccuracies - just my opinion.https://t.co/zkMPYPCW3r https://t.co/ZfnWgV6aMY
Dr. John Cush RheumNow ( View Tweet)
2023 EULAR classification criteria for hand osteoarthritis
A EULAR consensus group has established classification criteria for overall hand osteoarthritis (OA) and its subtypes (interphalangeal OA and thumb base OA).
https://t.co/wIgjYB2rXF https://t.co/TjSILyC4IT https://t.co/3x6YtXW81u
Dr. John Cush RheumNow ( View Tweet)
Israeli study shows the prevalence of Psoriatic arthritis has tripled since 2006
- 2006: 0.073%
- 2016: 0.165%
- 2022: 0.221%
~2 fold higher rate if Jewish, High SES, Obese
https://t.co/RMWcIZvfjb https://t.co/9H6sauSEZK https://t.co/Fhj64pADdJ
Links:
Dr. John Cush RheumNow ( View Tweet)
Ankylosing spondylitis Tx w/ Tofa- How quick do they respond? Post hoc analysis 269 pts:
- 4 wks for Pain >30%
- 4 wks for ASDAS improved ≥ 1.1 points
- 8-24 wks for ≥ 50% improved pain, enthesitis, AM stiffness, BASDAI & fatigue
https://t.co/YOZgRLfPNc https://t.co/egkG76gz2E https://t.co/ZknXhKE0N4
Links:
Dr. John Cush RheumNow ( View Tweet)
FDA has approved upadacitinib (Rinvoq), for use in pediatric patients (age >2 years) w/ active polyarticular juvenile idiopathic arthritis (pJIA) & psoriatic arthritis (PsA), after inadequate resp/intolerance to TNFi. Also available as oral solution. https://t.co/dZ21V2cKwR https://t.co/QADVP2w3Tz
Dr. John Cush RheumNow ( View Tweet)
Review of the Scleroderma spectrum disorders (full-read) https://t.co/Z7cUrVeGRR https://t.co/VkYag0uZnX https://t.co/QK6bfcYBoF
Dr. John Cush RheumNow ( View Tweet)
Full read review on Psoriasis Flares; risks:
- mechanical stress
- infections
-dysbiosis
-drugs (Lithium, B-blockers, HCQ, tetracyclines, ACEi, IFN)
- environment(smoking, obesity)
-lifestyle
- stress
- hormonal/metabolic https://t.co/WfCzcG9XNM https://t.co/ZNeKxjtHSA https://t.co/sJDoSfFOL4
Dr. John Cush RheumNow ( View Tweet)
NEJM Images - Polyarteritis Nodosa. 62 yoM with myalgias, wt loss, numbness, negative ANCA & HBV. Abdominal angiography shows multiple aneurysms. https://t.co/ONiQ82HWtj https://t.co/WIgOEywqAS https://t.co/ftjobeQDcL
Dr. John Cush RheumNow ( View Tweet)
Is there an Increasing Risk for Tick-Borne Disease ? JAMA article purports this to be so..... I think not - not unless you live in endemic areas. Other wise these still are rare, rare or misdiagnosis based on serologic inaccuracies - just my opinion.https://t.co/Sfu2UlLlwH https://t.co/z5TpNrDCWD
Dr. John Cush RheumNow ( View Tweet)
Intl Consensus: Generalized Pustular Psoriasis... systemic inflammatory disease characterized by cutaneous erythema and ...sterile pustules.” ...with or without systemic symptoms. GPP may (b) acute... w/ widespread pustules or subacute w/ annular phenotype https://t.co/dsKsQQYyj4 https://t.co/FVoTaw7mPl
Dr. John Cush RheumNow ( View Tweet)
When the EMR goes down, what do you do?
Dr. John Cush RheumNow ( View Tweet)
JAK or TNF Inhibitor as First Drug for Rheumatoid Arthritis?
A JAK inhibitor outperformed TNF blockers for substantially reducing RA symptoms in patients for whom conventional anti-rheumatic drugs had failed, a pragmatic head-to-head trial found.
https://t.co/7BhFSwb1Ns https://t.co/Hf31OPgE0M
Dr. John Cush RheumNow ( View Tweet)
2023 EULAR classification criteria for hand osteoarthritis
A EULAR consensus group has established classification criteria for overall hand osteoarthritis (OA) and its subtypes (interphalangeal OA and thumb base OA).
https://t.co/r7hR1rkjb7 https://t.co/IBC0BpNlW8
Dr. John Cush RheumNow ( View Tweet)
ACR Calls on CMS for Enhanced Transparency & Reporting
The ACR has submitted its response to the CMS)request for information (RFI) and feedback from stakeholders on how best to enhance MA data capabilities and increase public transparency.
https://t.co/vWPXlhmUGo https://t.co/Z8s3PZijqE
Dr. John Cush RheumNow ( View Tweet)
Study of 150 #PsA pts & Aortic stiffness (carotid-femoral pulse wave velocity (cfPWV) - cfPWV signif higher in PsA vs controls (p=0.034). , cfPWV assoc w/ Dz duration (r=0.3), systolic BP, GFR, RDW. cfPWV was superior to SCORE (16% vs 8.7%) at CV risk https://t.co/H6SbsIdXw0 https://t.co/Yt19QCk9TT
Dr. John Cush RheumNow ( View Tweet)
Chinese study of 552 pts w/ ANCA Assoc. Vasculitis - 23 had cancer prior to AAV Dx; 43 after Dx (w/in 4.3yrs)= SIR: 2.24. CA mostly lung CA (SIR: 5), followed by kidney, bladder, ureter, prostate. Higher risk if male (HR:2.8) and older (per year, HR:1.04) https://t.co/xhH3uU3GCj
Dr. John Cush RheumNow ( View Tweet)