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Metanalysis of 36 studies, 608 RA-Bronchiectasis among 8569 RA pts; pooled bronchiectasis prevalence in RA was 18.7% (range 15.5% to 20.7%). Risk factors: older age, longer RA duration, genetics (CFTR & HLA), undetectable MBL biomarker https://t.co/SSRoTCYkHf

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Dr. John Cush RheumNow ( View Tweet)

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RheumNow Podcast – COVID Marching Amidst the Madness (8.27.2021)

d Jack Cush, MD

We have a lot of news, information and approvals to review and discuss, though I need to begin with what's weighing heavily on my mind. After, we'll dive into what we learned this week.

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2021–22 influenza season coincides with continued COVID infx & Sxs may be confused betw both. ACIP Influenza vaccination guidelines: 1. Annual flu vaccine rec to all >6mos; 2. COVID Vax can be given w/ Flu Vax; 3. give before Nov 2021 https://t.co/oIkl50GI0W

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Dr. John Cush RheumNow ( View Tweet)

#ClinicalPearl My pt’s rheumatoid nodules ⬇️ when she continued off her #methotrexate post #CovidVaccine. She restarted her JAKi + #plaquenil https://t.co/FqNX9k7FUN
Janet Pope Janetbirdope ( View Tweet)
Cognitive impairment (CI) is not a consequence of having rheumatoid arthritis (OR = 1.12, 0.80–1.58). Population survey study of 4262 adults >50 yrs. 63% of RA had normal cognition , 25% w/ CI, 12% dementia (similar to non-RA- 66%, 22%, 12%) https://t.co/7RFOk8Nrkm

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Dr. John Cush RheumNow ( View Tweet)

virus,injection,COVID,vaccine

ACR Guidance on Timing of 3rd Dose Booster with Immunomodulatory Drugs

d ACR Press Release

The American College of Rheumatology has issued an updated version of its COVID-19 Vaccine Clinical Guidance for Patients with Rheumatic and Musculoskeletal Diseases following recent recommendations from the CDC that certain immunocompromised patients receive a third dose of an availabl

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Stiffness,hand,MCP,joint,pain

The Predictive Value of Morning Stiffness

d Jack Cush, MD

A prospective study evaluated the value and associations with morning stiffness in patients with clinically suspect arthralgia, and found that the presence of morning stiffness increases the odds of inflammation (as detected by CRP and MRI synovitis).

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Among pregnant women, receipt of the BNT162b2 vaccine was associated with a 78% lower risk of incident SARS-CoV-2 infection. Cohort study tincluded 15 060 pregnant women in Israel. No adverse pregnancy outcome difference in Vax Pts https://t.co/jXUjaKIfUV

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Dr. John Cush RheumNow ( View Tweet)

A current report in Arthritis & Rheumatology examined the Nurses Health Study II data set and shows that parental smoking and passive exposure to children, can later lead to an increased risk of adult-onset incident seropositive rheumatoid arthritis (RA). https://t.co/szl5L7DGJG https://t.co/yxoEquyLjP

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Dr. John Cush RheumNow ( View Tweet)
Rheums--have a question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. https://t.co/wzNmOzH4VE https://t.co/QJn6Uo3lbM

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Dr. John Cush RheumNow ( View Tweet)
cigarette,tobacco,smoking,fumes

Passive Smoke Exposure and Rheumatoid Risk

d Jack Cush, MD

A current report in Arthritis & Rheumatology examined the Nurses Health Study II data set and shows that parental smoking, and passive exposure to children, can later lead to an increased risk of adult-onset incident seropositive rheumatoid arthritis (RA).

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European Commission has approved tofacitinib (Xeljanz) to treat active polyarticular juvenile idiopathic arthritis & juvenile psoriatic arthritis (PsA) > 2yrs old, not responding to DMARDs (as tablet & new oral solution (weight-based dosing) https://t.co/FyqZI0qsYa

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Dr. John Cush RheumNow ( View Tweet)

Watch Now: Using Vitamin D in RA https://t.co/QXYVsa5jzP https://t.co/J9zxOUVRVY

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Dr. John Cush RheumNow ( View Tweet)
The CDC has reported that mRNA vaccine effectiveness against COVID-19–associated hospitalizations was sustained over 24 weeks; but there is evidence of waning protection amongst the immunosuppressed. https://t.co/UpQjFgKTpE https://t.co/3dQ2jacwJD

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Dr. John Cush RheumNow ( View Tweet)
#RA & Driving studied w/ installed auto sensor-based instrumentation - 23 controls compared to 33 RA pts (1292 driving hrs): shows RA & worsening Dz severity assoc w/ poor vehicle control; Braking/accelerating & steering variability liked to CDAI levels. https://t.co/umXGAbuicz https://t.co/EYxVVkzxR8

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Dr. John Cush RheumNow ( View Tweet)
New podcast available for download wherever you get your podcasts! We review the big stories on RheumNow this week. https://t.co/dbX9RN8ji5 https://t.co/WEf7yCR9km

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Dr. John Cush RheumNow ( View Tweet)
ICYMI Spirometry study in 2,008 #RA patients - compared to controls, RA has a higher risk of restrictive Lung dz (OR 1.36, 95%CI 1.21,1.52) and obstructive LD (OR 1.21, 95%CI 1.07,1.37) independent of confounders like smoking https://t.co/UWViAZtvYg https://t.co/VhgxascvEG

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Dr. John Cush RheumNow ( View Tweet)
Treatment of RA may be difficult, as it is estimated that up to 10% of patients meet the EULAR definition of difficult-to-treat rheumatoid arthritis (D2T RA). Now a EULAR task force has promulgated several points to consider (PtCs) in managing D2T RA. https://t.co/w4EWHD3RC4 https://t.co/s4q7jpitC8

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Dr. John Cush RheumNow ( View Tweet)
RA.Deformities.jpg

EULAR Points on Managing Difficult Rheumatoid Arthritis

d Jack Cush, MD

A EULAR task force has promulgated several points to consider in managing difficult-to-treat RA. These "points" are unique in directing the rheumatologist's attention to the potential for misdiagnosis and the impact of comorbid conditions on what is perceived as poorly controlled RA.

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Acute CPPD arthritis -1697 pts compared w/ 6503 controls. CPPD pts were older (74 yrs), 57% female, 81% White; & assoc w/ OA (OR 3.1), male (OR 1.3), RA (2.1), gout (2.8), PPI (1.9), diuretics (~1.5). CPPD less likely in Blacks vs Whites (OR 0.47) https://t.co/U22jBmjWXm

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Dr. John Cush RheumNow ( View Tweet)

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