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Featured BSR Abstracts (5.2.2024)

d Jack Cush, MD

Dr. Jack Cush muses on the news, journal reports, FDA announcements and the 2024 BSR abstracts just released.

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legs, sneakers

Lower Limb Muscle Mass Influences Osteoarthritis Risk

d Jack Cush, MD

The Rotterdam study shows that weight-bearing recreational physical activity caused more incident knee osteoarthritis (KOA), but mainly when there was low muscle mass. KOA risk is traditionally linked to either obesity or injury. This study assesses whether muscle mass may influence osteoarthritis risk.

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Methotrexate Does Not Increase ILD Risk in Dermatomyositis

d Jack Cush, MD

A cohort analysis of dermatomyositis (DM) patients starting immunomodulators finds that methotrexate use was not associated with an increased risk of interstitial lung disease (ILD).

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Complex Autoantibody Patterns in RA

d EurekAlert!

Patients with rheumatoid arthritis (RA) all have a unique and diverse set of antibodies that are involved in the development of the disease.

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Systemic Inflammation and Mortality in RA-ILD

d Jack Cush, MD

Analysis of the German RABBIT registry shows that systemic inflammation, more so than disease activity, strongly influences all-cause mortality in patients with rheumatoid arthritis and prevalent interstitial lung disease (RA-ILD).

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🏆Dr. Georg Schett's pioneering work in CAR-T for #autoimmune disease has landed him among the TIME100 Most Influential People in Health “Not only are the patients in drug-free remission, but I believe many are cured of their autoimmune disease," he said https://t.co/Rj7FpkluNg

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Healio Rheumatology HealioRheum ( View Tweet)

Full read review of IL-18 binding protein, natural antagonist of IL-18 . https://t.co/cGVQeyrXd9 https://t.co/XRhk9Ut0TN

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Dr. John Cush RheumNow ( View Tweet)
Biology and Rx of Lupus Flares https://t.co/VlaI1PK8X8 https://t.co/oFXqGUvL4b

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Dr. John Cush RheumNow ( View Tweet)
CAR T-Cell Therapy in Autoimmune Disease | New England Journal of Medicine https://t.co/VKlNGVDfyw. - persistence of CAR-T cells needs exploration

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Peter Nash drpnash ( View Tweet)

Biomarker Predictors of Osteoarthritis Science Advances has reported that Duke University researchers have validated a biomarkers of osteoarthritis that may be identified 2 years before the appearance of radiographic OA. S https://t.co/T9XQ3x9yc2 https://t.co/HdwbXR1nDX

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Dr. John Cush RheumNow ( View Tweet)
ARCTIC Rewind: Can You Taper DMARDs with Remission? https://t.co/5Mkdyt4DIK https://t.co/0Z2gVpjIgX

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Dr. John Cush RheumNow ( View Tweet)
Very late onset Lupus (>60) is less female, less arthritis/dz activity, lower dsDNA, C3, SSA, SSB and ANA but more Sjogrens & RA? Single clinic study of 845 SLE - jSLE (<18), aSLE (18-49), lSLE (50-60), and vlSLE (>60). vlSLE had lowest survival (20yrs) https://t.co/i3nQPVGYeP https://t.co/fiJe1g3AI3

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Dr. John Cush RheumNow ( View Tweet)
TLR Antagonist in Lupus An investigational TLR ) antagonist was effective in reducing biomarkers and clinical symptoms of SLE in a pilot trial, evidence that the innate immune system may hold the key to lupus pathophysiology. https://t.co/QSX3fRXRLs https://t.co/jt5nVer2ZQ

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Dr. John Cush RheumNow ( View Tweet)
ICYMI: What are the Early Stages of Lupus? https://t.co/2ACuh2WirF

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Dr. John Cush RheumNow ( View Tweet)

Mexican study 202 #SLE pts shows 89 (45.1%) were hospitalized; their profile was they were younger, shorter Dz duration, higher disease activity scores (SLEDAI), and more damage. Hosp were for Dz activity (61%), Renal Dz, infection, drug toxicity (5.6%)https://t.co/3TKb1ck18V https://t.co/om2R3kfpFY

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Dr. John Cush RheumNow ( View Tweet)
Study of f 234 AAV pts. 85 (36%) developed diffuse alveolar haemorrhage. Independent predictors of DAH: 1) Age [OR=1.037); 2) PLT # [OR=0.996]; 3) ESR [OR=1.028]; 4) HgB [OR=0.978]; 5) hematuria [OR=3.77] https://t.co/eKOu5PHs4R https://t.co/mGwLAVJhAN

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Dr. John Cush RheumNow ( View Tweet)
“50% of pts with lupus nephritis are asymptomatic . You have to have a degree of kidney damage before you have proteinuria. Proteinuria does not correlate with intrarenal activity.” – Dr. A Fava #RNL2024 @rheumnow https://t.co/UOC8MZDM8N

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Dr. John Cush RheumNow ( View Tweet)

Danish registry study shows positive association between maternal autoimmune Dz & childhood cancer. AID assoc w/ all child CA (OR=1.25), ALL (1.52), Burkitts (2.69), CNS tumors (1.45). RA mothers AID had higher risk of all cancers (OR=2.1) https://t.co/EYHyHzOboc https://t.co/FNRrvySI8P

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Dr. John Cush RheumNow ( View Tweet)
Dr. Gabalawy: "How do you know what disease patients will develop in this preclinical autoimmunity state?" @drdavidkarp ""it's like when weeds pop up in a garden, it's random ...if ACPA Ab pops up, you might have RA, if it's dsDNA, maybe lupus."" #RNL2024 https://t.co/kDkDaDRP8X

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Dr. John Cush RheumNow ( View Tweet)

Low urinary IL16 levels at 12 months predicts kidney survival at 3 years better than proteinuria - @Andreafava @rheumnow #RNL2024 https://t.co/4GLmJQr46C

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Dr. John Cush RheumNow ( View Tweet)

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