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SEAM-RA: SDAI remission greater in pts on ETN alone vs. MTX alone; ⬆ pts in remission w/ combined tx vs. MTX alone. These may guide tx decisions re withdrawal in well-controlled RA @Rheumnow #ACR20 https://t.co/33GhuMuL3I

sheila RHEUMarampa ( View Tweet)
ACPA+ RA should likely NOT taper bDMARDs as less Bio survival if ACPA+ &/or monoRx. Should EULAR guidelines be changed? What about retention with JAKis? #ACR20 @RheumNow @CRASCRRheum abstr804 https://t.co/vjzIIgVJ0s
Janet Pope Janetbirdope ( View Tweet)
In this study of RA pts w/ b/tsDMARDs tx, continuous decrease in RF titers was assoc'd w/ radiographic remission. Other factors were dse duration<5yrs, pred<5mg/d & time-integrated DAS28ESR. @RheumNow #ACR20 abs0754 https://t.co/u0pgAsK4UX
sheila RHEUMarampa ( View Tweet)
Anti-PAD Abs seen in 1/3 of pts at-risk for RA and 1/3 of pts w/ CSA. Implications? Possible predictive value of anti-PAD Abs in RA dse progression? @RheumNow #ACR20 abs0761 #ACRbest https://t.co/VpkjwU2YZm
sheila RHEUMarampa ( View Tweet)
Do pts with RA take their meds & can adherence intervention work? Yes & No. Pts starting new bDMARD RCT of electronic monitoring feedback vs usual care, adherence>80%. Neg RCT Maybe chronic users with poor adherence is group to study abstr#0799 #ACR2020 @RheumNow https://t.co/FyWoBjYnvs
Janet Pope Janetbirdope ( View Tweet)

Which Adalimumab biosimilar to use (if any)? The race is on to have 1st Ada or 2nd reimbursed/preferentially listed in US reimbursement plans & dare I say it mandatory switching like in Europe. Abstr#0798 #ACR2020 compares Abrilada & Humira in RA @RheumNow @CRASCRRheum https://t.co/AUcVZnc6Gj

Janet Pope Janetbirdope ( View Tweet)
What is your initial csDMARD of choice in pts w/ elderly-onset RA? @RheumNow #ACR20

sheila RHEUMarampa ( View Tweet)

Serial RF titers? Abst#0754 from Japan: Pts with RF>45, tracked RF at month 0/4/12 after starting b/tsDMARD. 46/130 had RF decrease titers, had better radiographic remission/DAS28-ESR. Limits: varied Rx, More aggressive Rx w RF decrease grp @RheumNow. #ACR20

Eric Dein ejdein1 ( View Tweet)

#ACR20 @RheumNow. We think of dichotomy of erosive vs. non-erosive but Abst#0748 shows joint space narrowing precedes erosive disease and requires more attention for early recognition. https://t.co/JLd3xVTlXM
Eric Dein ejdein1 ( View Tweet)
Will we start getting fine-specificity ACPAs to drive treatment of RA? Abst#0743 shows fs-ACPA (anti-fibrinogen B) predict greater response to ABA+MTX vs MTX alone. #ACR20 @RheumNow. Role of RA antibodies will continue to evolve and guide Rx. https://t.co/pY4mm19Jc7
Eric Dein ejdein1 ( View Tweet)
What do you think? The great debate continues... leave your thoughts in the comment section below! #ACR20 @RheumNow @LCalabreseDO @CCalabreseDO https://t.co/KwQX0XoO93

Links:

Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)

HCQ Not Associated with QTc Length in SLE and RA Patients: Dr. Janet Pope @Janetbirdope #ACR20 https://t.co/zPIaFIiqr5 https://t.co/Wk8YQpIpo7

Links:

Dr. John Cush RheumNow ( View Tweet)
EULAR19.abstract.jpg (keep)

ACR Best Abstracts - Day 1

d Jack Cush, MD

The RheumNow faculty reporters have been glued to their monitors all day, viewing video, reading and listening to abstract presentations and I charged them to earmark those presentations were the “Best” they saw today. Below is the list of most often noted #ACRbest abstracts from Day 1.

Read Article

Year in review by @JYazdanyMD ENTRACTE trial: CV safety of TCZ vs. ETN >similar CV events >TCZ grp slightly more infections & GI perforations @RheumNow #ACR20 https://t.co/yBDeHBDB3Z

sheila RHEUMarampa ( View Tweet)
Abst#0194 at #ACR20 showed that significant symptoms of depression in RA are more frequent than depression diagnosed clinically, suggesting that depression may go undiagnosed and that symptoms of depression predicted mortality in RA patients! @RheumNow https://t.co/GqwXNB45y2
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
ACPA+ and subclinical synovitis does not automatically mean developing to RA. Interesting work by Cleo Rogier et al. Something to consider in pts w/arthralgias & when to start csDMARDs @RheumNow #ACR20 Abstr#481 #ACRbest https://t.co/q3vIITmtq2
sheila RHEUMarampa ( View Tweet)
This convinces me! #TNF inhibitors vs #JAKI great debate at #ACR20 https://t.co/Xb8KkmDJ8f
KenWarringtonMD MdWarrington ( View Tweet)
Scoring hand x-rays for Sharp scores is painfully tedious and not always perfectly consistent. Why not get a computer to do it? Turns out you can - a deep adaptive machine learning model does as well as a human, each x-ray in literally one second. #ACR20 ABST0493 @RheumNow https://t.co/SvqkaFy8XZ
David Liew drdavidliew ( View Tweet)
Zonulin levels ⬆ in pre-RA/RA pts; activation of zonulin signalling leads to ⬆ intestinal permeability. Leaky gut - potential therapeutic target for RA? @RheumNow #ACR20 abs#492 https://t.co/C4TVrWwcYG
sheila RHEUMarampa ( View Tweet)
UK Biobank data: RA is associated with not just restrictive but also *obstructive* patterns on spirometry/PFTs (independent of smoking). Consistent observation; direction of causality? The lung in RA continues to fascinate. Prisco @jeffsparks et al #ACR20 ABST0491 @RheumNow https://t.co/LcjtAefnVF
David Liew drdavidliew ( View Tweet)

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