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Corticosteroid Use Hikes CV Risks in Rheumatic Patients

Jack Cush, MD

UK Clinical Practice Research Datalink population study shows that patients with immune-mediated inflammatory diseases, such as RA, PMR, GCA and IBD, have an augmented risk of CV outcomes with glucocorticoid use; even lower doses had a near doubling of their underlying CVD risk.

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PIANO Study - Safety of Biologics in Pregnancy

Jack Cush, MD

The results of the long awaited PIANO study have been reported in the journal Gastroenterology, showing that pregnant women with IBD may safely receive biologic or thiopurine therapy throughout the pregnancy without substantial added risk to the unborn or mother.

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RheumNow Podcast – ACR 20 is Coming to Town (10.30.20)

Jack Cush, MD

Dr Jack Cush overviews the RheumNow commitment, upcoming bonus coverage of ACR20 and the good news and journal reports from the past week on RheumNow.com

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Vedolizumab Promising in Immune-Related GI Events

Jack Cush, MD

Vedolizumab (Entyvio) was superior to infliximab (Remicade) for treating immune-mediated diarrhea and colitis (IMDC), a researcher reported.

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RheumNow Podcast – Back Talk: Questions from Listeners (10.23.20)

Jack Cush, MD

Dr. Jack Cush reviews the news, journal reports, survey results and "Back Talk" questions from Rheums.

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Oral Dysbiosis May Antedate Rheumatoid Arthritis

Jack Cush, MD

A study of oral microbiome in anti-cyclic citrullinated peptide (anti-CCP) positive at-risk individuals without synovitis (CCP+at risk) shows dysbiotic subgingival microbiomes and increased abundance of P. gingivalis compared with controls.

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2020 Nobel Prize in Medicine Goes to the Discovery of Hepatitis C

Jack Cush, MD

The Nobel Assembly at Karolinska Institutet has awarded the 2020 Nobel Prize in Physiology or Medicine jointly to Harvey J. Alter, Michael Houghton and Charles M. Rice for the discovery of Hepatitis C virus. These three scientists made a decisive contribution to the fight against blood-borne hepatitis C, a major global health problem that causes cirrhosis and liver cancer in people around the world.

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Comorbidities Impact Disease Activity in Spondyloarthritis

Jack Cush, MD

An analysis of a large population-based cohort of axial spondyloarthritis (axSpA) patients shows that comorbidities are common and are associated with higher disease activity and higher levels of functional impairment.

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Treatment Options for Extraintestinal IBD

Jack Cush, MD

Extraintestinal manifestations (EIMs) frequently accompany inflammatory bowel disease, often augmenting morbidity and mortality are associated with disease activity and may increase the need for surgery or treatment escalation.  A recent review in GUT details the treatment options for patients with EIM.

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#BestACR20Tweets RT @doctorRBC : AxSpa pts had Significant Gut Microbiome Differences in: 1⃣Disease activity and duration 2⃣Enthesitis 3⃣Radiographic involvement Abs#1853 https://t.co/ynemrgsP3W
Dr. John Cush RheumNow ( View Tweet)
Hypophosphatasia - CPPD/chondrocal, enthesop'y, DISH, exostoses - DDx of Low ALP: milk-alkali, Vit D intoxic'n, Wilson dz, via C def, celiac dz, adyn renal osteodystrophy, Cushing dz, hypothyroid, major sx, MM Rx - asfotase alpha- bone targeted replac't Rx #ACR20 #ACRambassador https://t.co/FJ1355MdKG
Vaneet K Sandhu, MD vksandhumd ( View Tweet)
In patients with Crohn's disease (CD), the presence of HLA-B27 and higher clinical activity of CD were associated with presence of SpA. SpA was present in 21% of early CD patients @RheumNow #ACR20 Abstr#1308

Dr. Antoni Chan synovialjoints ( View Tweet)

Minimum Clinically Important Improvement in Patients with Rheumatoid Arthritis Associates with Gut Microbiome https://t.co/D3ILR57gXY #RA #microbiome that microbiome again

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Peter Nash drpnash ( View Tweet)

Liver damage is NOT an extra-articular manifestation of RA BUT the ff'g factors are associated with liver disease in RA & can complicate management👇@RheumNow #ACR20 https://t.co/RqL69iVJpC
sheila RHEUMarampa ( View Tweet)
Lilly has announced results of Phase 2 SERENITY trial showing the IL-23 inhibitor, mirikizumab, was more effective than PBO at week 12 (PRO and endoscopic outcomes) in moderate to severe active Crohn's disease. Efficacy continued out to week 52 https://t.co/n8Mdeonmas

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Dr. John Cush RheumNow ( View Tweet)

Complement assoc. studied by Petri & Durcan in 2399 SLE pts. 55% had low C3 (pesistently low 4%); 47% low C4 (3% persistently low). Low C4 is weak marker clinical & serological Dz. Low C3 linked w/ renal & serological Dz, Low C3/C4 linked to ACL, CVA, DVT https://t.co/KgF7HNEYu8

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Dr. John Cush RheumNow ( View Tweet)

Danish matched (1:4) cohort study shows COVID-19 pts taking NSAIDs had no greater risk of mortality, hospitalization, ICU admission, mechanical ventilation, or renal replacement therapy; study included 9,236 COVID PCR-positive & 2.7% were on NSAIDs https://t.co/OuUbJ9FxiM

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Dr. John Cush RheumNow ( View Tweet)

Dr Uma Mahadevan and colleagues have published guidelines for managing pregnancy in IBD patients. Rec coordinated care w/ maternal-fetal medicine subspecialist, GI doc, preconception planning, more on treatement https://t.co/oAFcGlOU2y

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Dr. John Cush RheumNow ( View Tweet)

Comparative retrospective study of 251 ANCA+ pts with AAV (MPA or GPA) & severe renal Dz induction Rx with CYC or RTX, +/- PLEX. Remission equally achieved by CTX or RTX; addition of PLEX did not change outcomes. Predictors ESKD and death - eGFR <15 https://t.co/2lbGUS1ahv

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Dr. John Cush RheumNow ( View Tweet)

UK safety reminder that Baricitinib (Olumiant) has an increased risk of diverticulitis (incidence rate 0.16 per 100PY), esp. in those taking Steroids or NSAIDs. https://t.co/IfcV03e1p7

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Dr. John Cush RheumNow ( View Tweet)

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