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Clinical Pearl! @DrCassySims currently treats with ASA 81mg po daily during vasculitis pregnancies at 12 weeks for preeclampsia ppx. She notes there is some data/use of 162mg po daily in Europe which may change the way we practice in the future. #RNL2024 @RheumNow

Dr. Rachel Tate uptoTate ( View Tweet)

"Please remember to discuss personal goals with patients (such as having children) centered around options that would not risk personal health (disease worsening, flaring, death, etc), such as surrogacy in pregnancy." @DrCassySims @RheumNow #RNL2024

Dr. Rachel Tate uptoTate ( View Tweet)

We can do our best to optimize them for the best possible pregnancy outcomes? 1. Confirm pregnancy goals/timeline 2. Discuss patient’s disease activity over the past 12 mo 3. Document end organ damage and the last time this was assessed 4. Review medications 5. Check… https://t.co/7xQsGW9dKa

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Dr. Rachel Tate uptoTate ( View Tweet)

"The most successful pregnancies are planned during periods of well controlled disease on pregnancy compatible medications." Dr. C Sims #RNL2024 @RheumNow @DrCassySims

Dr. Rachel Tate uptoTate ( View Tweet)

Rheumatology drugs in pregnancy. Just missing leflunomide in that big no no section @DrCassySims @RheumNow #RNL2024 https://t.co/ZPtTGRqPki

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Richard Conway RichardPAConway ( View Tweet)
@DrCassySims: the Pregnancy Checklist for #Vasculitis patients @rheumnow #RNL2024 #ReproductiveRheumatology 👉confirm pregnancy goals 👉review meds, dz activity in the last 12 months 👉document end organ damage 👉assess Ro/La 👉discuss role of ASA 👉work w/ MFM/subspecialists https://t.co/5z4XeMRzGI

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TheDaoIndex KDAO2011 ( View Tweet)
Pregnancy in vasculitis checklist: - goals and timeline - disease activity in 12 mos - is there end organ damage? - Review Rx - h/o clots/miscarriages, APLS? - Check Ro/La - Role for ASA? - Refer to MFM Catherine Sims #RNL2024 @RheumNow

Eric Dein ericdeinmd ( View Tweet)

How do vasculitis pts do during pregnancy? Variable due to different diagnoses of flares Gatto 2012: TA 3% flare, GPA 45% flare Fredi 2015: 35% flare Nguyen 2021: LVV 25% flare, 36% SVV -Catherine Sims #RNL2024 @RheumNow

Eric Dein ericdeinmd ( View Tweet)

2nd kidney biopsy in lupus nephritis have value. @andreafava #RNL2024 @RheumNow https://t.co/47J1CGQL81

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Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
#RNL2024 day 2: - Vasculitis Pod with @anisha_dua and @philseo - STEP talks: @DrLisaCS on myositis malignancy screening, @EBRheum on ANCA myths, @RheumNow dead words in rheum - Spondy Pod with @JointMD @lihi_eder @LianneGensler

Eric Dein ericdeinmd ( View Tweet)

Proteinuria doesn’t correlate with internal activity in lupus nephritis , we really need better biomarkers. @andreafava #RNL2024 @RheumNow https://t.co/bFuxVnUCEB

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Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
This is a crucial nuance. Men and women experience pain differently. The tendency to use that to then dismiss pain in women is entirely incorrect. @lihi_eder @RheumNow #RNL2024 https://t.co/X5QQsaIuNP

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Richard Conway RichardPAConway ( View Tweet)
Dr. Gabalawy: "How do you know what disease patients will develop in this preclinical autoimmunity state?" @drdavidkarp "it's like when weeds pop up in a garden, it's random ...if ACPA Ab pops up, you might have RA, if it's dsDNA, maybe lupus." #RNL2024 @RheumNow https://t.co/JmDtaTt3sU

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TheDaoIndex KDAO2011 ( View Tweet)
Great talk -this is a summary slide on lupus nephritis and biomarkers to predict renal survival. When you get a chance, you have to watch @andreafava on #RNL2024 https://t.co/3PgFWCU9n6 @RheumNow https://t.co/AZNq9XrTMx

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TheDaoIndex KDAO2011 ( View Tweet)
Combining results of urinary IL16, PR3, CD163 at 12 months best predicts kidney function protection at 3 years - @andreafava #RNL2024 @rheumnow https://t.co/0XV0MrhL1F

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TheDaoIndex KDAO2011 ( View Tweet)
Low urine IL-16 at 12 months predicted kidney survival much better than proteinuria. Check out AUCs in the this first slide. Dr. @andreafava reviews this potential biomarker. Question if this could also be a possible target for treatment as well? #RNL2024 @RheumNow https://t.co/cCLRERVXmq

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Dr. Rachel Tate uptoTate ( View Tweet)
Low urinary IL16 levels at 12 months predicts kidney suvial at 3 years better than proteinuria - @Andreafava @rheumnow #RNL2024 https://t.co/AEaL8n2nv8

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TheDaoIndex KDAO2011 ( View Tweet)
@andreafava @jhrheumatology Urinary biomarkers (CD163, IL-16) at 3 months predict the 1 year response better than UPCR - At 6 & 12 mos predicts renal survival at 3 yrs - At 12 mos: IL-16 92% accurate, sens 97%, Spec 80% vs UPCR 72% accurate, 75% sens, spec 67% #ACR2024 @RheumNow https://t.co/YtbCrwrch0

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Eric Dein ericdeinmd ( View Tweet)
Scary! A third of patient with lupus nephritis who are considered complete respondues continue to aaccrue progressive renal damage - @Andreafava @rheumnow #RNL2024 https://t.co/mhu3YoY3YV

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TheDaoIndex KDAO2011 ( View Tweet)
1/3 of lupus nephritis patient classified as "complete responders" continued to accrue progressive renal damage despite resolution of proteinuria over 1 year. Dr. @andreafava reviews GFR trajectories after renal bx at #RNL2024 @RheumNow https://t.co/nYJZWw9jUL

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Dr. Rachel Tate uptoTate ( View Tweet)
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